Combined Effect of Aerobic and Resistance Exercise in Non Ischemic Dilated Cardiomyopathy Patients

NCT07062874 | Not Yet Recruiting

• 1 other identifier: REC/RCR&AHS/24/0359
• Study Type: interventional
• Target: 66
• Locations: 1 country
• Sites: 1

Brief Summary

This study explores the effects of combined aerobic and resistance exercise in patients with non-ischemic dilated cardiomyopathy (NIDCM). In a six-week randomized clinical trial with 66 participants, both exercise groups-combined and aerobic-only-showed significant improvements in exercise capacity, functional independence, dyspnea, and blood pressure. However, no significant difference was found between the two groups. The study concludes that both exercise approaches are effective, but longer studies are needed to determine if combined training offers added benefits.

Conditions

CARDIOMYOPATHY

Keywords

Cardiomyopathy, Dyspnea, Exercise, Functional Independence, NIDCM.

Outcome Measures

Primary Outcomes (2)

• Functional Independence Measure (FIM) questionnaire

  Assesses level of functional independence across self-care, mobility, communication, and social cognition.

  Baseline and 6 weeks

• VO₂ Max (Maximum Oxygen Consumption)

  Measured using Graded Exercise Test (GXT) to assess cardiovascular fitness.

  Baseline and 6 weeks.

Secondary Outcomes (2)

• Modified Borg Dyspnea Scale

  Baseline and 6 weeks.

• Blood Pressure (Systolic and Diastolic)

  Baseline and 6 weeks.

Study Arms (2)

Combined Aerobic and Resistance Exercise:

EXPERIMENTAL

Participants performed aerobic training three times a week for six weeks. Each session included a 10-minute warm-up, 30-minute main aerobic activity (60-85% of heart rate reserve using the Karvonen formula), and 10-minute cool-down. Additionally, they performed resistance exercises for upper and lower extremities using TheraBands, 8-10 sets covering major muscle groups, three times a week.

Behavioral: Combined Aerobic and Resistance Exercise; Behavioral: Aerobic Exercise Only

Aerobic Exercise Only

ACTIVE COMPARATOR

Participants followed the same aerobic training protocol as Group A. No resistance training was included. Sessions also occurred three times a week for six weeks, with similar warm-up, active, and cool-down phases.

Behavioral: Aerobic Exercise Only

Interventions

Combined Aerobic and Resistance Exercise BEHAVIORAL

Participants received supervised exercise training 3 times per week for 6 weeks. Each session included a 10-minute warm-up (walking at 1.5 km/h), a 30-minute aerobic phase at 60-85% heart rate reserve (calculated using the Karvonen formula), and a 10-minute cool-down (walking at 1 km/h). In addition, participants performed resistance training for upper and lower extremities using TheraBands, with 8-10 sets targeting major muscle groups.

Also known as: Resistance training

Combined Aerobic and Resistance Exercise:

Aerobic Exercise Only BEHAVIORAL

Participants followed the same aerobic training protocol as the experimental group-3 sessions per week for 6 weeks, with 10-minute warm-up, 30-minute aerobic exercise (60-85% HRR), and 10-minute cool-down. No resistance training was provided.

Aerobic Exercise Only; Combined Aerobic and Resistance Exercise:

Eligibility Criteria

• Age: 40 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Both male and female Age 40 to 60
• Left ventricular ejection fraction \<50%

You may not qualify if:

• Patients diagnosed with valvular heart disease, supraventricular arrhythmias, congenital heart disease were excluded.
• Neuromuscular diseases such as stroke, Parkinson.
• Underlying pulmonary disease
• Impaired cognitive function (14)

Sponsors & Collaborators

• Riphah International University: lead

Study Sites (1)

Arjumand

Lahore, Punjab Province, 40100, Pakistan

Location

MeSH Terms

Conditions

Cardiomyopathies; Dyspnea; Motor Activity

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Heart Diseases; Cardiovascular Diseases; Respiration Disorders; Respiratory Tract Diseases; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Arjumand Bano, MS-CPPT

  Riphah International University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

imran amjad, phd

CONTACT

03324390125; imran.amjad@riphah.edu.pk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 3, 2025
• First Posted: July 14, 2025
• Study Start: July 28, 2025
• Primary Completion: September 28, 2025
• Study Completion: October 10, 2025
• Last Updated: July 14, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)