Rhythmic Walking Program and Renal Function and Oxidative Stress

NCT07059559 | Completed DMC

• 1 other identifier: BRO 2024-074
• Study Type: interventional
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

This study designed a over-knee automatic step counter device. Then, we evaluated its efficacy on renal function and oxidative stress in patients with chronic kidney disease.

Conditions

Renal Function

Outcome Measures

Primary Outcomes (5)

• Creatinine level

  Blood creatinine level was measured in mg/dL unit

  Day 0 and day 91

• Malondialdehyde level

  Blood malondialdehyde level was measured in micromolar unit

  Day 0 and day 91

• Superoxide dismutase activity level

  Blood superoxide dismutase activity level was measured in percent unit

  Day 0 and day 91

• Estimated glomerular filtration rate level

  Estimated glomerular filtration rate level was measured in ml/min/1.73 m2 unit

  Day 0 and day 91

• Estimated creatinine clearance level

  Estimated creatinine clearance level was measured in ml/min unit

  Day 0 and day 91

Study Arms (2)

Control group

NO INTERVENTION

Patients who join in odd-numbered order, such as 1st, 3rd, 5th, etc., will receive standard care as provided by the hospital (control group).

Rhythmic walking group

EXPERIMENTAL

Patients who join in even-numbered order, such as 2nd, 4th, 6th, etc., will receive a walking program. This involves continuous walking exercise for 30 minutes, once a day, three days a week, over a period of three months. During the walking sessions, patients will walk at a pace of 60 steps per minute, or one step per second.

Other: Rhythmic walking

Interventions

Rhythmic walking OTHER

Patients who consent to participate and pass the screening process were randomly assigned to groups based on the order of their participation (random by sequence): control group or rhythmic walking group.

Rhythmic walking group

Eligibility Criteria

• Age: 18 Years - 59 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Male or female
• Aged between 18 and 59 years
• Diagnosed by a physician with chronic kidney disease stage 2-4, with a glomerular filtration rate (GFR) between 15-89 milliliters per minute, persisting for at least 3 months

You may not qualify if:

• No musculoskeletal disorders that hinder walking, such as osteoarthritis
• Not engaging in regular exercise (less than 3 times per week or less than 150 minutes per week)
• Not regularly taking medications or supplements containing antioxidants

Sponsors & Collaborators

• Burapha University: lead

Study Sites (1)

Rehabilitation Medicine Department, Chamni Hospital

Chamni, Changwat Buri Ram, 31110, Thailand

Location

Study Officials

• Piyapong Prasertsri, Ph.D.

  Faculty of Allied Health Sciences, Burapha University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: Outcome assessors were blinded to the intervention administered to each patient.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor Dr.

Model Details: This study is a randomized controlled trial. Patients who consent to participate and pass the screening process will be randomly assigned to groups based on the order of their participation (random by sequence). Patients who join in odd-numbered order, such as 1st, 3rd, 5th, etc., will receive standard care as provided by the hospital (control group). Patients who join in even-numbered order, such as 2nd, 4th, 6th, etc., will receive a walking program.

Study Record Dates

• First Submitted: July 1, 2025
• First Posted: July 11, 2025
• Study Start: July 17, 2024
• Primary Completion: July 1, 2025
• Study Completion: July 1, 2025
• Last Updated: July 11, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

TH (1)