Training in Combination With Non-invasive Brain Stimulation

NCT07059533 | Completed

• 1 other identifier: 2017-00301
• Study Type: interventional
• Target: 88
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this study is to investigate the impact of non-invasive brain stimulation on motor skill acquisition in healthy individuals. Participants performed a motor task with non-invasive brain stimulation applied over the area of the brain where movements were controlled. The study compared motor skill performance between with the active stimulation and the placebo stimulation.

Conditions

Motor Skill Acquisition in Healthy Older Adults

Keywords

Non-invasive brain stimulation; Transcranial direct current stimulation

Outcome Measures

Primary Outcomes (1)

• Motor performance

  Replication of a nine-digit sequence displayed on a screen, as quickly and as accurately as possible, using the left hand

  From the start of the practice to the end of training at 5 days (and follow up on the 10th day and 60th day)

Study Arms (2)

Verum

EXPERIMENTAL

anodal transcranial direct current stimulation

Other: Verum

Placebo

PLACEBO COMPARATOR

40 seconds of stimulation delivered at the beginning of training (with 8 seconds ramp-up and 5 seconds ramp-down times)

Other: Placebo

Interventions

Verum OTHER

anodal transcranial direct current stimulation: 20 minutes of stimulation with 1 mA (ramp-up/ramp-down times of 8 seconds)

Verum

Placebo OTHER

anodal transcranial direct current stimulation with 40 seconds of stimulation delivered at the beginning of training (with 8 seconds ramp-up and 5 seconds ramp-down times)

Placebo

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• age equals to or over 18 years old
• absence of major neurological, psychiatric and physical impairment, with normal or corrected to normal vision
• right handed
• in good general health

You may not qualify if:

• professional musicians/stenotypist
• unable to consent
• unable to perform the task as required (instructions and setup)

Sponsors & Collaborators

• Friedhelm Hummel: lead

Study Sites (1)

Campus Biotech

Geneva, Canton of Geneva, 1202, Switzerland

Location

MeSH Terms

Interventions

calcium D-pantothenate, L-cysteine drug combination

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Full professor

Model Details: We randomly assigned participants to receive either real or placebo stimulation

Study Record Dates

• First Submitted: July 1, 2025
• First Posted: July 10, 2025
• Study Start: March 31, 2017
• Primary Completion: January 31, 2025
• Study Completion: January 31, 2025
• Last Updated: July 10, 2025

Record last verified: 2025-07

Locations

CH (1)