Neuropathic Characteristics of Subacromial Pain Syndrome

NCT07057128 | Recruiting

• 1 other identifier: SAPS-NP
• Study Type: observational
• Target: 82
• Locations: 1 country
• Sites: 1

Brief Summary

This single-center observational study aims to investigate neuropathic pain descriptors and their relationship with central sensitization in patients diagnosed with subacromial pain syndrome (SAPS) who have had shoulder pain for at least 3 months. A total of 82 participants aged 19 years or older will be recruited from the Physical Medicine and Rehabilitation outpatient clinic of Izmir City Hospital. After obtaining informed consent, participants will complete validated questionnaires assessing pain severity (VAS), neuropathic pain characteristics (painDETECT), central sensitization (Central Sensitization Inventory), and shoulder function (SPADI). Range of motion will be measured using a goniometer. No imaging or invasive procedures will be performed. Using the central sensitization scale and pain detect, the presence or absence of the 7 pain descriptors will be investigated in patients with subacromial pain syndrome with or without central sensitization and neuropathic pain pattern and it will be investigated whether the contribution of hyperalgesia, one of these pain descriptors, to neuropathic pain and central sensitization in patients with subacromial pain syndrome is greater than the contribution of other pain descriptors.The results of this study are expected to provide insight into pain mechanisms and guide clinical management in patients with SAPS.

Conditions

Neuropathic Pain; Central Sensitization; Subacromial Pain Syndrome

Outcome Measures

Primary Outcomes (1)

• Hyperalgesia

  Hyperalgesia is defined as an exaggerated pain response to a painful stimulus that is disproportionate to the intensity of the stimulus. It is one of the pain descriptors assessed in the painDETECT questionnaire, which evaluates neuropathic pain features.It is one of the 7 questions in the painDETECT scale that evaluates neuropathic pain and is scored on a 6-point Likert scale and receives a score between 0-5.

  At baseline (single assessment)

Secondary Outcomes (5)

• Pain Intensity

  At baseline

• Neuropathic Pain

  At baseline

• Central Sensitization

  At baseline

• Function

  At baseline

• Range of Motion Measurement

  At baseline

Eligibility Criteria

• Age: 19 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study will be conducted with 82 patients aged 19 years and older who have been admitted to the PTR outpatient clinic of Izmir City Hospital with shoulder pain and diagnosed with subacromial pain syndrome and who have had shoulder pain for at least 3 months.

You may qualify if:

• Clinical diagnosis of subacromial pain syndrome (SAPS)
• Age ≥ 19 years
• Shoulder pain lasting for at least 3 months
• Shoulder pain intensity rated as 3 or higher on the Visual Analog Scale (VAS) in the past week
• Positive findings on the following clinical tests:
• Hawkins-Kennedy test Painful arc test Infraspinatus muscle strength test

You may not qualify if:

• History of inflammatory disease involving the shoulder joint
• History of neurological disorders
• History of prior shoulder surgery
• Positive drop arm test
• Loss of passive range of motion in the shoulder joint
• Presence of muscle strength loss
• Structurally confirmed shoulder pathology based on imaging studies
• Full-thickness tear of the rotator cuff muscles
• Presence of neurodeficit in the upper extremity
• Diagnosis of cancer or active infection
• Use of medications for neuropathic pain within the past 3 months for any reason

Sponsors & Collaborators

• Izmir City Hospital: lead

Study Sites (1)

İzmir City Hospital

Izmir, İzmir, 35300, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Neuralgia

Condition Hierarchy (Ancestors)

Peripheral Nervous System Diseases; Neuromuscular Diseases; Nervous System Diseases; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Doctor, Department of Physical Medicine and Rehabilitation, Izmir City Hospital

Study Record Dates

• First Submitted: June 28, 2025
• First Posted: July 9, 2025
• Study Start: September 15, 2025
• Primary Completion: March 26, 2026
• Study Completion (Estimated): June 1, 2026
• Last Updated: April 14, 2026

Record last verified: 2026-04

Locations

TU (1)