Low Dose of Norepinephrine Within 24-Hour Mortality in Traumatic Patient With Hemorrhagic Shock

NCT07053163 | Completed

• 1 other identifier: 36264MS298/8/24
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the work is to evaluate role of low dose of nor epinephrine administration in the early 24-hour period among traumatic patients and hemorrhagic shock. The primary outcome: evaluate mortality at first 24 hour. The secondary outcome : measure total fluid intake, observe renal functions and Hemodynamic changes.

Conditions

Mortality Rate; Hemorrhagic Shock

Keywords

Norepinephrine; Mortality; Traumatic Patient; Hemorrhagic Shock

Outcome Measures

Primary Outcomes (1)

• Mortality

  at first 24 hour

Secondary Outcomes (1)

• total fluid intake

  at first 24 hour

Study Arms (2)

Crystalloid and blood as resuscitation

EXPERIMENTAL

Patients receive crystalloid and blood as resuscitation.

Drug: Crystalloid and blood as resuscitation

Crystalloid& blood and low dose of norepinephrine

EXPERIMENTAL

receive crystalloid, blood and low dose of norepinephrine.

Drug: crystalloid, blood and low dose of norepinephrine

Interventions

Crystalloid and blood as resuscitation DRUG

Patients receive crystalloid and blood as resuscitation

Crystalloid and blood as resuscitation

crystalloid, blood and low dose of norepinephrine DRUG

Group 2: receive crystalloid, blood and low dose of norepinephrine

Crystalloid& blood and low dose of norepinephrine

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Patients 18 -65 Years old.
• Multiple organ injury.
• Recent trauma within 1st 24 hour.
• Mean arterial blood pressure \<65 mmHg

You may not qualify if:

• Cardiac arrest at admission.
• Old trauma more than 24 hour.
• Severe brain or spinal injury (because of different target blood pressures).
• Death due to haemostatic failure within 6 hours of admission

Sponsors & Collaborators

• Tanta University: lead

Study Sites (1)

Tanta University

Tanta, Gharbia Governorate, Egypt

Location

MeSH Terms

Conditions

Shock, Hemorrhagic

Interventions

Crystalloid Solutions; Blood Specimen Collection; Resuscitation; Norepinephrine

Condition Hierarchy (Ancestors)

Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Shock

Intervention Hierarchy (Ancestors)

Isotonic Solutions; Solutions; Pharmaceutical Preparations; Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques; Emergency Treatment; Therapeutics; Ethanolamines; Amino Alcohols; Alcohols; Organic Chemicals; Amines; Biogenic Monoamines; Biogenic Amines; Catecholamines; Catechols; Phenols; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons

Study Officials

• Radwa Abdeldayem, Resident

  Tanta University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident

Study Record Dates

• First Submitted: June 27, 2025
• First Posted: July 8, 2025
• Study Start: August 30, 2024
• Primary Completion: August 30, 2024
• Study Completion: September 30, 2024
• Last Updated: July 11, 2025

Record last verified: 2023-09

Data Sharing

• IPD Sharing: Will share

Locations

EG (1)