Risk Factors and Outcomes in Patients Treated in Neurocritical Care

NCT07052656 | Completed

• 2 other identifiers: K2022-6426KI: 4-1998/2022
• Study Type: observational
• Target: 70,000
• Locations: 1 country
• Sites: 1

Brief Summary

The overall purpose of this epidemiologic research project is to provide a comprehensive exploration and analysis of critical elements within the neuro-intensive care process in Sweden. All aspects of intensive care management in critically ill patients with acute brain injury will be addressed. The analyses include description of patient characteristics, intensive care data, management and treatments, various aspects of short and long-term follow-up, mortality, regional- and sex-related differences. The long-term goal is to develop neuro-intensive care and management, to minimize in-hospital insults and secondary injuries, to improve diagnostics and follow-up, in order to reduce prolonged neurologic deficits and mortality in these patients.

Conditions

Neuro-intensive Care Unit Patients; Subarachnoid Hemorrhage, Aneurysmal; Ischemic Stroke; Intracerebral Hemorrhage; Stroke, Acute; Meningitis; Epilepsy; Traumatic Brain Injury; Acute Brain Injuries; Acute Neurological Injury

Outcome Measures

Primary Outcomes (1)

• Mortality

  Mortality

  Up to two years

Secondary Outcomes (1)

• Morbidity

  Up to two years

Other Outcomes (2)

• DAOH90

  90 days

• Complications

  90 days

Study Arms (1)

Neuro-intensive care patients

Other: Observational study, participants are not assigned an intervention as part of the study.; Other: Transport modality

Interventions

Observational study, participants are not assigned an intervention as part of the study. OTHER

Observational study, participants are not assigned an intervention as part of the study.

Neuro-intensive care patients

Transport modality OTHER

Transfer modality to tertiary centers

Neuro-intensive care patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients 18 years or older treated in an ICU in Sweden with a clinical diagnosis of subarachnoid hemorrhage, intracranial hemorrhage, ischemic brain injury, traumatic brain injury, epilepsy, meningitis, encefalitis or other brain injury diagnosis from 2010 to 2024.

You may qualify if:

• ICU admission 2010 to 2024
• Clinical diagnosis of subarachnoid hemorrhage, intracranial hemorrhage or ischemic brain injury, traumatic brain injury, epilepsy, meningitis, encefalititis or other brain injury diagnosis.

Sponsors & Collaborators

• Karolinska Institutet: lead
• Karolinska University Hospital: collaborator

Study Sites (1)

Karolinska University Hospital

Stockholm, Sweden

Location

MeSH Terms

Conditions

Subarachnoid Hemorrhage; Ischemic Stroke; Cerebral Hemorrhage; Stroke; Meningitis; Epilepsy; Brain Injuries, Traumatic; Brain Injuries

Interventions

Observation

Condition Hierarchy (Ancestors)

Intracranial Hemorrhages; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Neuroinflammatory Diseases; Craniocerebral Trauma; Trauma, Nervous System; Wounds and Injuries

Intervention Hierarchy (Ancestors)

Methods; Investigative Techniques

Study Officials

• Linn Hallqvist, MD, PhD

  Dep of Perioperative Medicine and Intensive care, Karolinska University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 2 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD, PhD, Consultant, Principal Investigator

Study Record Dates

• First Submitted: May 28, 2025
• First Posted: July 4, 2025
• Study Start: January 1, 2010
• Primary Completion: December 31, 2024
• Study Completion: December 31, 2024
• Last Updated: July 10, 2025

Record last verified: 2025-07

Locations

SE (1)