Antibiotic Treatment for Pneumonia Caused by Stenotrophomonas Maltophilia in ICU Patients

NCT07052604 | Recruiting

• 1 other identifier: 0055_STENO
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

This study looks at how different antibiotic treatments affect patients in intensive care who have pneumonia caused by the bacteria Stenotrophomonas maltophilia. It compares using one antibiotic versus two antibiotics, and treatment lengths of 7 days versus 14 days, to see which approach helps patients survive better. The study also examines how resistant the bacteria are to antibiotics and how often the pneumonia comes back.

Conditions

Pneumonia, Ventilator-Associated; Stenotrophomonas Maltophilia; Intensive Care Units; Anti-Bacterial Agents; Drug Resistance, Bacterial

Outcome Measures

Primary Outcomes (1)

• patient survival based on the antibiotic treatment strategy used (monotherapy vs. combination therapy and 7 vs. 14 days duration).

  28 days

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of adult patients admitted to the Medical Intensive Care Unit (ICU) between January 2018 and December 2023 who are intubated and mechanically ventilated, and who develop ventilator-associated pneumonia caused by Stenotrophomonas maltophilia. These patients represent a critical care group at high risk for serious infections with multidrug-resistant bacteria.

You may qualify if:

• Adult patients (age ≥ 18 years)
• Hospitalized in Medical Intensive Care Unit between January 1, 2018, and December 31, 2023
• Intubated and mechanically ventilated
• Diagnosed with ventilator-associated pneumonia caused by Stenotrophomonas maltophilia

You may not qualify if:

• Patients under 18 years old
• Patients who refuse the use of their data for research purposes

Sponsors & Collaborators

• Centre Hospitalier de Saint-Denis: lead

Study Sites (1)

Centre Hospitalier de Saint-Denis

Saint-Denis, France, France

RECRUITING

MeSH Terms

Conditions

Pneumonia, Ventilator-Associated

Condition Hierarchy (Ancestors)

Healthcare-Associated Pneumonia; Cross Infection; Infections; Pneumonia; Respiratory Tract Infections; Lung Diseases; Respiratory Tract Diseases; Iatrogenic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 26, 2025
• First Posted: July 4, 2025
• Study Start: December 15, 2023
• Primary Completion: September 15, 2025
• Study Completion: September 15, 2025
• Last Updated: July 4, 2025

Record last verified: 2025-06

Locations

FR (1)