Trials Sponsors Conditions Drugs Pricing

Conditions

Alzheimer Disease (AD)Healthy Mild Cognitive Impairment (MCI)Subjective Cognitive Decline (SCD)

Outcome Measures

Primary Outcomes (1)

Plasma biomarkers
Levels of plasma biomarkers associated with neurodegeneration and brain health will be compared between stimulation and sham interventions.
Blood samples will be collected the morning after each intervention phase. Interventions are separated by one week.

Secondary Outcomes (9)

Glymphatic function
MRI scans will be performed the morning after each intervention phase. Interventions are separated by one week.
CLAS evoked responses
Each night of sleep during each intervention phase, whether receiving stimulation or sham.
Slow wave activity (SWA)
Each night of sleep during each intervention phase, whether receiving stimulation or sham.
Sleep architecture
Each night of sleep during each intervention phase, whether receiving stimulation or sham.
Change in memory performance
Before and after each intervention period. Interventions are separated by one week.
+4 more secondary outcomes

Study Arms (6)

Healthy young, auditory stimulation, then sham

EXPERIMENTAL

Other: Closed-loop acoustic stimulation

Healthy young, sham, then auditory stimulation

EXPERIMENTAL

Other: Closed-loop acoustic stimulation

Healthy old, auditory stimulation, then sham

EXPERIMENTAL

Other: Closed-loop acoustic stimulation

Interventions

Closed-loop acoustic stimulationOther

At-home sleep will be monitored using an EEG headband. Non-awakening auditory stimuli will be delivered during non-rapid eye movement sleep (NREM), timed to the ascending phase of slow waves, using either active or control (sham) conditions.

Healthy old, auditory stimulation, then shamHealthy old, sham then auditory stimulationHealthy young, auditory stimulation, then shamHealthy young, sham, then auditory stimulationPositive amyloid load group, auditory stimulation, then shamPositive amyloid load group, sham, then auditory stimulation

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age18 Years - 80 Years

Sexall

Healthy VolunteersYes

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

Proficiency in the French language (close to native level) to complete the neuropsychological evaluation and cognitive tests.
MRI compatibility: absence of metallic materials in the body (implants, vascular clips, certain types of orthopedic material, etc.), a pacemaker or other types of stimulators, cochlear implants, or any other electronic devices.

Sponsors & Collaborators

University of Amsterdam
Othercollaborator
Erasme University Hospital
Otherlead

Study Sites (1)

Hôpital Universitaire de Bruxelles

Brussels, Belgium

Mélanie StraussCONTACT+32 2 555 55 39 melanie.strauss@hubruxelles.be

MeSH Terms

Conditions

Cognitive DysfunctionAlzheimer Disease

Condition Hierarchy (Ancestors)

Cognition DisordersNeurocognitive DisordersMental DisordersDementiaBrain DiseasesCentral Nervous System DiseasesNervous System DiseasesTauopathiesNeurodegenerative Diseases

Study Officials

Mélanie Strauss, MD, PhD
Université Libre de Bruxelles
PRINCIPAL INVESTIGATOR

Central Study Contacts

Mélanie Strauss, MD, PhD

CONTACT

+32 2 555 55 39 melanie.strauss@hubruxelles.be

Rebeca Sifuentes Ortega, PhD

CONTACT

rebeca.sifuentes.ortega@ulb.be

Study Design

Study Type: interventional
Phase: not applicable
Allocation: RANDOMIZED
Masking: SINGLE
Who Masked: PARTICIPANT
Purpose: BASIC SCIENCE
Intervention Model: CROSSOVER
Sponsor Type: OTHER
Responsible Party: SPONSOR

Study Record Dates

First Submitted

June 26, 2025

First Posted

July 4, 2025

Study Start

September 2025

Estimated (date passed)

This estimate has passed. The registry has not confirmed an actual date for this milestone.

Primary Completion

September 2028

Sleep Stimulation to Enhance Waste Clearance in the Brain

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (9)

Study Arms (6)

Healthy young, auditory stimulation, then sham

Healthy young, sham, then auditory stimulation

Healthy old, auditory stimulation, then sham

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

Healthy old, sham then auditory stimulation

Positive amyloid load group, auditory stimulation, then sham

Positive amyloid load group, sham, then auditory stimulation

You may not qualify if:

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Outcome Measures

Primary Outcomes (1)

Secondary Outcomes (9)

Study Arms (6)

Healthy young, auditory stimulation, then sham

Healthy young, sham, then auditory stimulation

Healthy old, auditory stimulation, then sham

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

Healthy old, sham then auditory stimulation

Positive amyloid load group, auditory stimulation, then sham

Positive amyloid load group, sham, then auditory stimulation

You may not qualify if:

Data Sharing

Source record

Locations