The Risk Factors Related to Rupture Flow-related Aneurysms in Posterior AVM

NCT07050381 | Recruiting

• 1 other identifier: pAVM-rFA
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 2

Brief Summary

AVMs have been reported to rupture at a formidable annual rate of 2% to 3% at natural progression, often resulting in longterm neurological deficits and poor functional outcomes.The reported risk of hemorrhagic presentation in patients with AVMs is 41% to 65%. While many studies suggest a correlation between higher hemorrhage risk and the concurrent presence of AVM and aneurysms, few authors have focused specifically on flow-related aneurysms alone. In many instances, the source of rupture is also unclear. Meta-analysis from 2016 suggested that 49.2% of hemorrhages were secondary to aneurysm rupture, 45% from AVM rupture, and 5.7% were undetermined.In a study of 302 patients, of which 52.6% had a hemorrhagic presentation, demonstrated a significant increase in rate of hemorrhage in those with flow-related aneurysms. Thus, it is necessary to figure out risk factors related to ruptured flow-related aneurysms in pAVM.

Conditions

Arteriovenous Malformation of Central Nervous System; Aneurysm, Ruptured; Aneurysmatic Subarachnoid Haemorrhage; Aneurysm Cerebral

Keywords

arteriovenous malformation; flow-related aneurysm; ruptured aneurysm; subarachnoid hemorrhage

Outcome Measures

Primary Outcomes (1)

• characteristics of flow-related aneurysm

  size ratio(aneurysm depth (mm)/parent artery diameter (mm))

  From enrollment to the end of treatment at 8 weeks

Other Outcomes (5)

• demographic information of pAVM-rFA

  From enrollment to the end of treatment at 8 weeks

• demographic information

  From enrollment to the end of treatment at 8 weeks

• characteristics of flow-related aneurysm

  From enrollment to the end of treatment at 8 weeks

Study Arms (2)

pAVM with ruptured flow-related aneurysm

pAVM without ruptured flow-related aneurysm

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with posterior circulation malformations combined with ruptured or unruptured flow-related aneurysms will be included. Morphological data such as aneurysm size, location, parent artery, feeding arteries, draining vein count, malformation size, malformation location, and the ratio of malformation/aneurysm volume will be analyzed. These factors will be examined alongside medical histories of hypertension, diabetes, and coronary artery disease to investigate the risk factors for ruptured flow-related aneurysms.

You may qualify if:

• pAVM with flow-related aneurysms were identified by DSA, and subarachnoid hemorrhage was confirmed by CT
• No history of stroke, Marfan syndrome, polycystic kidney disease

You may not qualify if:

• pAVM without flow-related aneurysms
• Absence of clinical data

Sponsors & Collaborators

• The First Affiliated Hospital with Nanjing Medical University: lead

Study Sites (2)

Jiangsu Province Hospital

Nanjing, Jiangsu, 225500, China

ACTIVE NOT RECRUITING

the First Affiliated Hospital of Nanjing Medical University

Nanjing, Jiangsu, China

RECRUITING

Related Publications (4)

• Hung AL, Yang W, Jiang B, Garzon-Muvdi T, Caplan JM, Colby GP, Coon AL, Tamargo RJ, Huang J. The Effect of Flow-Related Aneurysms on Hemorrhagic Risk of Intracranial Arteriovenous Malformations. Neurosurgery. 2019 Oct 1;85(4):466-475. doi: 10.1093/neuros/nyy360.

  PMID: 30107479 BACKGROUND

• Shakur SF, Amin-Hanjani S, Mostafa H, Charbel FT, Alaraj A. Hemodynamic Characteristics of Cerebral Arteriovenous Malformation Feeder Vessels With and Without Aneurysms. Stroke. 2015 Jul;46(7):1997-9. doi: 10.1161/STROKEAHA.115.009545. Epub 2015 May 19.

  PMID: 25991417 BACKGROUND

• Kouznetsov E, Weill A, Ghostine JS, Gentric JC, Raymond J, Roy D. Association between posterior fossa arteriovenous malformations and prenidal aneurysm rupture: potential impact on management. Neurosurg Focus. 2014 Sep;37(3):E4. doi: 10.3171/2014.6.FOCUS14219.

  PMID: 25175442 BACKGROUND

• Lv X, Wu Z, Jiang C, Yang X, Li Y, Sun Y, Zhang N. Angioarchitectural characteristics of brain arteriovenous malformations with and without hemorrhage. World Neurosurg. 2011 Jul-Aug;76(1-2):95-9. doi: 10.1016/j.wneu.2011.01.044.

  PMID: 21839959 BACKGROUND

MeSH Terms

Conditions

Aneurysm, Ruptured; Intracranial Aneurysm; Arteriovenous Malformations; Subarachnoid Hemorrhage

Condition Hierarchy (Ancestors)

Aneurysm; Vascular Diseases; Cardiovascular Diseases; Intracranial Arterial Diseases; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Malformations; Cardiovascular Abnormalities; Congenital Abnormalities; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Intracranial Hemorrhages; Hemorrhage; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Yifei Wang

CONTACT

+86-13852665323; wangyifei5323@163.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: professor

Study Record Dates

• First Submitted: February 10, 2025
• First Posted: July 3, 2025
• Study Start: June 13, 2025
• Primary Completion: August 31, 2025
• Study Completion (Estimated): December 31, 2026
• Last Updated: July 3, 2025

Record last verified: 2025-06

Locations

CN (2)