Post-Operative Analgesic Effect of Tramadol and Nalbuphine in Smoker and Non-Smoker Patients in LC

NCT07049380 | Active Not Recruiting DMC

• 1 other identifier: MSAHSW/Batch-Fall23/910
• Study Type: observational
• Target: 132
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to compare pain severity and analgesic requirements between smokers and nonsmokers following laparoscopic cholecystectomy, evaluating the efficacy of two analgesics, tramadol and nalbuphine.

Conditions

Laparocele

Outcome Measures

Primary Outcomes (1)

• Visual Analog Scale (VAS)

  The Visual Analog Scale (VAS) is a tool used to measure pain intensity, mood, or other subjective experiences. It typically involves a 10 cm (100mm) line with descriptive anchors at each end, such as "no pain" and "worst pain imaginable

  12 Months

Interventions

Comparative cross sectional DIAGNOSTIC_TEST

evaluating the efficacy of two analgesics, tramadol and nalbuphine. The primary objectives are to estimate pain severity in smokers versus nonsmokers and identify the effect of tramadol and nalbuphine between these groups

Eligibility Criteria

• Age: 30 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study anticipates revealing significant variations in pain perception and analgesic requirements, potentially guiding tailored perioperative protocols for smokers. By addressing gaps in pain management strategies specific to smoking status, this research could enhance postoperative recovery outcomes and inform clinical practices for optimizing analgesia in diverse patient populations.

You may qualify if:

• Both Male and female patients are included.
• Adults' patients with Greater than 30 years of age
• Both Smoker and non-Smokers patients are added (Patients who are chain smoker at least 10 cigarettes per day).

You may not qualify if:

• Patients are excluded if they have smoking history other than cigarettes smoking like Vapes, Cigar and smokeless tobacco.

Sponsors & Collaborators

• Superior University: lead

Study Sites (1)

Allama Iqbal Teaching hospital

Dera Ghazi Khan, Punjab Province, Pakistan

Location

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: June 25, 2025
• First Posted: July 3, 2025
• Study Start: March 17, 2025
• Primary Completion: August 1, 2025
• Study Completion: February 28, 2026
• Last Updated: July 3, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

PA (1)