Evidence-Based Nursing for Psychological Resilience in Lung Cancer Chemotherapy Patients

NCT07049250 | Completed

• 1 other identifier: 2024S00040
• Study Type: interventional
• Target: 142
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigates the effect of an evidence-based nursing intervention, guided by a quantitative evaluation strategy, on psychological resilience and illness perception in lung cancer patients undergoing chemotherapy. Patients were randomized to receive either the specialized nursing intervention or routine nursing care, with outcomes assessed at baseline and 3 months post-intervention.

Conditions

Lung Cancer

Keywords

Chemotherapy; Psychological Resilience; Illness Perception; Evidence-Based Nursing; Quantitative Evaluation Strategy

Outcome Measures

Primary Outcomes (1)

• Change in Psychological Resilience Score

  Psychological resilience assessed using the 25-item Resilience Scale. Scores range from 0 to 100, with higher scores indicating better psychological resilience. The scale measures optimism, resilience, and strength subdomains.

  Baseline and 3 months post-intervention.

Secondary Outcomes (3)

• Change in Illness Perception

  Baseline and 3 months post-intervention.

• Change in Coping Styles

  Baseline and 3 months post-intervention.

• Incidence of Chemotherapy-Related Complications

  Assessed throughout the 3-month post-intervention period.

Study Arms (2)

Evidence-Based Nursing Intervention Group

EXPERIMENTAL

Participants (n=71) received evidence-based nursing intervention guided by quantitative evaluation strategy. This included: 1) comprehensive risk assessments by a multidisciplinary team; 2) dynamic risk stratification for care intensity; 3) psychological and cognitive interventions (cognitive-behavioral techniques, peer mentoring, family counseling); 4) systematic complication prevention strategies (prophylactic antiemetics, dietary guidance, infection control); 5) sleep optimization protocols.

Behavioral: Evidence-Based Nursing Intervention under Quantitative Evaluation Strategy

Routine Nursing Care Group

ACTIVE COMPARATOR

Participants (n=71) received routine nursing care. This consisted of standard disease education covering chemotherapy side effects and self-management strategies, personalized exercise guidance focusing on maintaining physical function, and medication adherence counseling, delivered in 30-minute sessions twice weekly for a duration of two months.

Behavioral: Routine Nursing Care

Interventions

Evidence-Based Nursing Intervention under Quantitative Evaluation Strategy BEHAVIORAL

A multifaceted nursing program incorporating comprehensive risk assessment, dynamic risk stratification, psychological and cognitive interventions (including cognitive-behavioral techniques, peer mentoring, family counseling), systematic complication prevention strategies (including prophylactic antiemetics, dietary guidance, infection control), and sleep optimization protocols.

Evidence-Based Nursing Intervention Group

Routine Nursing Care BEHAVIORAL

Standard disease education on chemotherapy side effects and self-management, personalized exercise guidance, and medication adherence counseling. Delivered in 30-minute sessions twice weekly for two months.

Routine Nursing Care Group

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosis of lung cancer confirmed according to the Chinese Quality Control Indicators for Standardized Diagnosis and Treatment of Primary Lung Cancer (2022) through both imaging and histopathological examination.
• TNM staging determined using the 8th edition AJCC/UICC classification system.
• Scheduled to receive chemotherapy with an expected survival exceeding one year.
• Demonstrated normal cognitive and communication abilities as assessed by standardized neuropsychological tests.
• Provided written informed consent prior to enrollment.

You may not qualify if:

• Pre-existing neurological disorders.
• Significant organ dysfunction (defined as Child-Pugh class B/C for liver function or eGFR \<30 mL/min/1.73m² for renal function).
• Active infectious diseases.
• Contraindications to chemotherapy.
• Concurrent radiotherapy.

Sponsors & Collaborators

• The First Hospital of Hebei Medical University: lead

Study Sites (1)

The First Hospital of Hebei Medical University

Shijiazhuang, Hebei, 050000, China

Location

MeSH Terms

Conditions

Lung Neoplasms

Condition Hierarchy (Ancestors)

Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: SUPPORTIVE CARE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator

Study Record Dates

• First Submitted: June 25, 2025
• First Posted: July 3, 2025
• Study Start: March 1, 2024
• Primary Completion: March 1, 2025
• Study Completion: March 1, 2025
• Last Updated: July 3, 2025

Record last verified: 2025-06

Locations

CN (1)