Comparison of the Effectiveness of Articaine Local Infusion and Lidocaine Nerve Block in Lower Posterior Tooth Extraction.

NCT07048834 | Completed Phase 2 DMC

• 1 other identifier: 1419
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

In this study 60 adult patients will participate and divided into two groups (30 for each). The first group will be anesthetized using 2 % lidocaine with 1:80,000 adrenaline by inferior alveolar nerve block technique, while the second group will be anesthetized using 4 % articaine with 1:100,000 adrenaline via buccal and lingual infiltration technique in posterior teeth area. Then patients will wait for five minutes after receiving a local anesthetic injection before extraction could begin. After that every tooth's buccal, lingual, mesial, and distal surfaces will be examined using a disposable dental explorer. Then by visual analog scale (VAS) which provides accessible, sensitive, valid, and reliable means to measure a variety of subjective parameters the pain score will be registered during tooth extraction. Female patients who are breastfeeding or pregnant, those allergic to local anesthetics, lacking full mental ability, currently taking opioids, having an infection at the extraction site, or those under the influence of medicines that alter their perception of pain will be excluded from the study.

Conditions

Anesthesia

Outcome Measures

Primary Outcomes (1)

• visual analog scale (VAS)

  It usually is a horizontal line, 100 mm in length, anchored by word descriptors at each end, for example, that represent the severity of symptoms from 0 "no symptoms" to 10 "very severe symptoms." The patient marks on the line the point that the patient believes represents his or her perception of his or her current state.

  five minutes

Study Arms (2)

patients anesthetized by 2 % lidocaine with 1:80,000 adrenaline by inferior alveolar nerve block.

OTHER

This group of (30 patients) will be anesthetized using 2 % lidocaine with 1:80,000 adrenaline by inferior alveolar nerve block technique, Then patients will wait for five minutes after receiving a local anesthetic injection before extraction could begin. After that every tooth's buccal, lingual, mesial, and distal surfaces will be examined using a disposable dental explorer. Then by visual analog scale (VAS) which provides accessible, sensitive, valid, and reliable means to measure a variety of subjective parameters the pain score will be registered during tooth extraction

Other: lidocaine local anesthetic drug

anesthetized by 4 % articaine with 1:100,000 adrenaline via buccal and lingual infiltration.

OTHER

This group (of 30 patients) will be anesthetized using 4 % articaine with 1:100,000 adrenaline via buccal and lingual infiltration technique in posterior teeth area. Then patients will wait for five minutes after receiving a local anesthetic injection before extraction could begin. After that every tooth's buccal, lingual, mesial, and distal surfaces will be examined using a disposable dental explorer. Then by visual analog scale (VAS) which provides accessible, sensitive, valid, and reliable means to measure a variety of subjective parameters the pain score will be registered during tooth extraction.

Other: articaine local anesthetic drug

Interventions

lidocaine local anesthetic drug OTHER

Lidocaine Nerve Block technique

patients anesthetized by 2 % lidocaine with 1:80,000 adrenaline by inferior alveolar nerve block.

articaine local anesthetic drug OTHER

Articaine Local Infusion technique

anesthetized by 4 % articaine with 1:100,000 adrenaline via buccal and lingual infiltration.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• clinically healthy patients

You may not qualify if:

• Breastfeeding or pregnant
• Allergic to local anaesthetics drugs
• Lack full mental ability
• Infection at the extraction site
• Patient who currently taking opioids or under the influence of medicines that alter their perception of pain are not candidates for tooth extraction

Sponsors & Collaborators

• Amjed Fouad Hussein: lead

Study Sites (1)

Ahl Al Bayt University

Karbala, Iraq

Location

Related Publications (1)

• Webster S Jr, Drum M, Reader A, Fowler S, Nusstein J, Beck M. How Effective Is Supplemental Intraseptal Anesthesia in Patients with Symptomatic Irreversible Pulpitis? J Endod. 2016 Oct;42(10):1453-7. doi: 10.1016/j.joen.2016.07.002.

  PMID: 27663614 BACKGROUND

Related Links

• Related Info
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Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assistant Lecturer

Study Record Dates

• First Submitted: May 21, 2025
• First Posted: July 3, 2025
• Study Start: March 15, 2021
• Primary Completion: February 20, 2022
• Study Completion: May 17, 2022
• Last Updated: July 9, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will not share

Locations

IR (1)