Effect of Exergaming Program Versus Neuromuscular Exercise in Elderly People With Motor Cognitive Risk Syndrome

NCT07045259 | Recruiting DMC

• 1 other identifier: 2025/701
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The primary aim of our study is to compare the effects of neuromuscular exercise training versus structured exergaming program on locomotor and cognitive functions in elderly individuals with Motor Cognitive Risk (MCR), which defines the transition state between typical aging and dementia and mild cognitive impairment. This study aims to present for the first time the effects of neuromuscular exercise training and exergaming program on locomotor and cognitive functions in elderly individuals with MCR with comparative results.

Conditions

Elderly (People Aged 65 or More); Geriatric Patient; Exergaming; Neuromuscular Exercise; Motoric Cognitive Risk Syndrome

Keywords

Motoric Cognitive Risk Syndrome; Elderly; neuromuscular exercise; exergaming

Outcome Measures

Primary Outcomes (3)

• Timed Up and Go Test (TUG)

  TUG test is a frequently used field test to evaluate mobility, balance, fall risk and walking in elderly individuals (Magda,2024; (Racha, 2023). The test involves the individual getting up from a chair, walking 3 meters, turning, and sitting. The time taken to complete this series of movements is measured and recorded using a stopwatch (Racha, 2023).

  From enrollment to the end of treatment at 8 weeks

• Stair Climbing Test (SCT)

  The stair climbing test is frequently used in the evaluation of locomotor functions in elderly individuals. The validity and reliability of the STAIR, which has been investigated in elderly people with knee osteoarthritis, has been reported to have a test-retest reliability coefficient of 0.93 and high reliability (Jose, 2021). In our study, they will be asked to ascend and descend 4 steps, each of which is 50 cm wide, 15 cm high and 25 cm deep, as quickly but safely as possible. They will be able to use the handrails when they need to while ascending or descending the stairs, and the total time taken to complete the task will be measured in seconds with a stopwatch.

  From enrollment to the end of treatment at 8 weeks

• Cognitive Officer TUG-SCT

  In our research * Counting backwards from 50 by threes * Cognitive officer TUG and SCT tests will be conducted to answer the questions prepared by the researchers as yes if red and no if blue, and the results will be recorded in terms of time (Li, 2023).

  From enrollment to the end of treatment at 8 weeks

Secondary Outcomes (7)

• Short Physical Performance Battery (SPPB)

  From enrollment to the end of treatment at 8 weeks

• Dynamic Gait Index (DGI)

  From enrollment to the end of treatment at 8 weeks

• Reaction speed assessment

  From enrollment to the end of treatment at 8 weeks

• Performance-Oriented Mobility Assessment

  From enrollment to the end of treatment at 8 weeks

• Berg Balance Assessment

  From enrollment to the end of treatment at 8 weeks

Other Outcomes (1)

• Satisfaction Level

  From enrollment to the end of treatment at 8 weeks

Study Arms (3)

The Neuromuscular Exercise Group

ACTIVE COMPARATOR

Other: Exergaming Exercise Training

Exergaming Group

ACTIVE COMPARATOR

Other: The Neuromuscular Exercise Training program

Control Group

NO INTERVENTION

Interventions

The Neuromuscular Exercise Training program OTHER

The Neuromuscular Exercise Training program will be carried out in groups of 2 people for 45 minutes/2 days/8 weeks. The exercise program will consist of warm-up, loading and cooling phases. The warm-up phase will consist of flexibility exercises, mini squat and roll down etc. exercises to prepare the individual for exercise. The loading phase will consist of a cognitive-based neuromuscular exercise program aiming to provide stabilization, increase in balance, neuroplasticity and motor control and is planned to include strengthening exercises, stabilization exercises, balance-proprioceptive exercises and neuromuscular control exercise training with visual feedback. The exercises will progress gradually from easy to difficult with increasing repetition and set numbers.

Exergaming Group

Exergaming Exercise Training OTHER

In our study, Xbox One Kinect game console and Kinect sensor will be used within the scope of Exergaming. Exergaming program will be carried out in groups of 2 people for 45 minutes/ 2 days/ 8 weeks. It will consist of warm-up, loading and cooling phases. The games to be used for the Exergaming program were selected from games that include locomotor and cognitive repetitive tasks. The selected exergames involve repetitive locomotor and cognitive tasks. Piano step will be utilized during the warm-up for its rhythm-based movement patterns. For the conditioning phase, lower extremity exercises will include Reflex Ridge, River Rush, and Rallyball (Kinect Adventures), while upper extremity exercises will consist of Bowling, Table Tennis, Swimming (Kinect Sports), and Fruit Ninja. A progressive training approach will be followed, with game difficulty levels increasing incrementally as the sessions advance.

The Neuromuscular Exercise Group

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• Being over 65 years of age
• Having a Barthel Daily Living Activities Index score of ≥ 90
• Having a Mini Mental Status Score (MMSE) of ≥24
• Having the ability to walk with or without a walking aid
• Having a slow walking speed
• Having subjective memory complaints

You may not qualify if:

• Presence of Dementia
• Major Depression
• Generalized Anxiety Disorder and Delirium
• Parkinson's Disease
• Anemia
• Thyroid Disease
• Vitamin B12 Deficiency
• Malnutrition
• Terminal Illness
• Hearing or Visual Impairment

Sponsors & Collaborators

• Istanbul University - Cerrahpasa: lead

Study Sites (1)

Balıkesir Üniversitesi

Balıkesir, Turkey (Türkiye)

RECRUITING

Related Publications (11)

• Davranche K, Burle B, Audiffren M, Hasbroucq T. Physical exercise facilitates motor processes in simple reaction time performance: an electromyographic analysis. Neurosci Lett. 2006 Mar 20;396(1):54-6. doi: 10.1016/j.neulet.2005.11.008. Epub 2006 Jan 10.

  PMID: 16406344 BACKGROUND

• Garcia MAC, Souza VH. The (un)standardized use of handheld dynamometers on the evaluation of muscle force output. Braz J Phys Ther. 2020 Jan-Feb;24(1):88-89. doi: 10.1016/j.bjpt.2019.10.004. Epub 2019 Nov 13. No abstract available.

  PMID: 31740163 BACKGROUND

• Zirek E, Mustafaoglu R, Cicek A, Ahmed I, Mavromoustakos S. Reliability and Validity of the Turkish Version of the Modified Dynamic Gait Index in the Elderly. Eval Health Prof. 2023 Jun;46(2):135-139. doi: 10.1177/01632787221128311. Epub 2022 Sep 17.

  PMID: 36121068 BACKGROUND

• Alghwiri AA. Reliability and validity of the Arabic Dynamic Gait Index in people poststroke. Top Stroke Rehabil. 2014 Mar-Apr;21(2):173-9. doi: 10.1310/tsr2102-173.

  PMID: 24710977 BACKGROUND

• Pahor M, Guralnik JM, Ambrosius WT, Blair S, Bonds DE, Church TS, Espeland MA, Fielding RA, Gill TM, Groessl EJ, King AC, Kritchevsky SB, Manini TM, McDermott MM, Miller ME, Newman AB, Rejeski WJ, Sink KM, Williamson JD; LIFE study investigators. Effect of structured physical activity on prevention of major mobility disability in older adults: the LIFE study randomized clinical trial. JAMA. 2014 Jun 18;311(23):2387-96. doi: 10.1001/jama.2014.5616.

  PMID: 24866862 BACKGROUND

• Corsonello A, Lattanzio F, Pedone C, Garasto S, Laino I, Bustacchini S, Pranno L, Mazzei B, Passarino G, Incalzi RA; Pharmacosurveillance In The Elderly Care Pvc Study Investigators. Prognostic significance of the short physical performance battery in older patients discharged from acute care hospitals. Rejuvenation Res. 2012 Feb;15(1):41-8. doi: 10.1089/rej.2011.1215. Epub 2011 Oct 17.

  PMID: 22004280 BACKGROUND

• Pavasini R, Guralnik J, Brown JC, di Bari M, Cesari M, Landi F, Vaes B, Legrand D, Verghese J, Wang C, Stenholm S, Ferrucci L, Lai JC, Bartes AA, Espaulella J, Ferrer M, Lim JY, Ensrud KE, Cawthon P, Turusheva A, Frolova E, Rolland Y, Lauwers V, Corsonello A, Kirk GD, Ferrari R, Volpato S, Campo G. Short Physical Performance Battery and all-cause mortality: systematic review and meta-analysis. BMC Med. 2016 Dec 22;14(1):215. doi: 10.1186/s12916-016-0763-7.

  PMID: 28003033 BACKGROUND

• Li Y, Yu N, Zhang C, Song Q, Wang J, Sun W. Test-retest reliability of kinematic and kinetic parameters during dual-task stair walking in the elderly. Front Physiol. 2023 May 9;14:1177159. doi: 10.3389/fphys.2023.1177159. eCollection 2023.

  PMID: 37228826 BACKGROUND

• Casana J, Calatayud J, Silvestre A, Sanchez-Frutos J, Andersen LL, Jakobsen MD, Ezzatvar Y, Alakhdar Y. Knee Extensor Muscle Strength Is More Important Than Postural Balance for Stair-Climbing Ability in Elderly Patients with Severe Knee Osteoarthritis. Int J Environ Res Public Health. 2021 Mar 31;18(7):3637. doi: 10.3390/ijerph18073637.

  PMID: 33807414 BACKGROUND

• Soubra R, Mourad-Chehade F, Chkeir A. Automation of the Timed Up and Go Test Using a Doppler Radar System for Gait and Balance Analysis in Elderly People. J Healthc Eng. 2023 Jun 29;2023:2016262. doi: 10.1155/2023/2016262. eCollection 2023.

  PMID: 37426725 BACKGROUND

• Reis M, Teixeira M, Carvao C, Martins AC. Validity and Reliability of the Self-Administered Timed Up and Go Test in Assessing Fall Risk in Community-Dwelling Older Adults. Geriatrics (Basel). 2025 Apr 29;10(3):62. doi: 10.3390/geriatrics10030062.

  PMID: 40407569 BACKGROUND

Study Officials

• Gulfidan TOKGÖZ, Lecturer, PhD (c)

  İstanbul University-Cerrahpasa

  PRINCIPAL INVESTIGATOR

• Saime Nilay ARMAN, Assoc. Prof. Dr.

  İstanbul University-Cerrahpasa

  STUDY DIRECTOR

Central Study Contacts

GULFİDAN TOKGÖZ, Lecturer, PhD (c)

CONTACT

+90552 022 76 32; gulfidan.tokgoz@gmail.com

Saime Nilay ARMAN, Assoc. Prof. Dr.

CONTACT

+90553 455 87 07; saimenilayarman@istanbul.edu.tr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Masking Details: Patients who meet the inclusion criteria will be randomized into three treatment groups, structured exergaming and neuromuscular exercise training and control group with a 1:1 block allocation. Randomization will be performed by a researcher not involved in the study using a website (www.randomization.com). Interventions and assessments will be administered by physiotherapists. After the end of treatment, both groups will be re-evaluated using the same procedures.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: İstanbul Üniversitesi-Cerrahpasa

Study Record Dates

• First Submitted: June 20, 2025
• First Posted: July 1, 2025
• Study Start: December 25, 2025
• Primary Completion: March 25, 2026
• Study Completion (Estimated): June 30, 2026
• Last Updated: April 24, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)