Lung Protective Ventilation and Driving Pressure Guided PEEP Titration in CABG Surgery

NCT07044089 | Recruiting

• 1 other identifier: KAEK/05.b1.01
• Study Type: observational
• Target: 86
• Locations: 1 country
• Sites: 1

Brief Summary

Our aim in this study is to compare fixed and individualized PEEP (driving pressure guided ) application for intraoperative lung protective ventilation in patients undergoing on-pump CABG surgery. Researcher aimed to compare the effects of two different PEEP application methods on intraoperative hemodynamics, respiratory mechanics, and gas exchange, as well as postoperative extubation times, respiratory complications (atelectasis, need for non invasive mechanical ventilatıon, need for re-entubatıon) length of stay in the intensive care unit, and discharge times.

Conditions

Peep Titration in Lung Protective Ventilation

Keywords

Lung Protective Ventilation; Fixed PEEP; Individualized PEEP

Outcome Measures

Primary Outcomes (1)

• Effects on intraoperative oxygenation, hemodynamics, lung compliance and airway pressures

  Data will be recorded during surgery and the first 24 hours after extubation.

  First one day

Study Arms (2)

Fixed PEEP

Indıvıdalızed PEEP

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients who will undergo elective on-pump coronary artery bypass graft surgery under general anesthesia

You may qualify if:

• Patients scheduled for elective on-pump coronary artery bypass graft surgery via median sternotomy
• Patients between the ages of 18 and 70
• ASA (American Society of Anesthesiologists) physical status classification II-III

You may not qualify if:

• Patients with an ejection fraction below 35%
• Patients who did not consent to participate in the study
• Patients undergoing emergency surgery
• Patients who are allergic to the anesthetic drugs used
• Patients who have undergone lung resection
• Those with a history of mechanical ventilation in the 2 months before surgery
• Patients who have undergone total circulatory arrest and deep hypothermia
• Patients with obstructive sleep apnea syndrome requiring long-term ventilation assistance
• Morbid obesity (Body Mass Index\>35kg/m2)
• Patients with refractory hypoxemia (arterial oxygen saturation below 88% despite 100% oxygen inhalation)
• COPD (FEV1\<70%)
• Patients with chronic renal failure (serum creatine\>1.8 mg/dl)
• Anemia (Hg\<10 gr/dl)
• Patients who have had an intraaortic balloon pump placed.

Sponsors & Collaborators

• Kocaeli University: lead

Study Sites (1)

Kocaeli University Faculty of Medicine

Kocaeli, izmit, 41100, Turkey (Türkiye)

RECRUITING

Central Study Contacts

Zeynep Açık, MD

CONTACT

+905077367990; zeynebacik96@gmail.com

Tülay Çardaközü, PROFESSOR

CONTACT

+905323262342; tulayhosten@hotmail.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Assistant Doctor

Study Record Dates

• First Submitted: June 23, 2025
• First Posted: June 29, 2025
• Study Start: July 23, 2025
• Primary Completion (Estimated): March 1, 2027
• Study Completion (Estimated): September 1, 2027
• Last Updated: August 8, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will share

Locations

TU (1)