NCT07041710

Brief Summary

Changes in taste and smell can occur during chemotherapy treatment. These chemotherapy-related side effects can negatively impact patients' quality of life and diet. The aim of this research is therefore to propose a solution to alleviate these taste and smell disorders. Based on the same principle as rehabilitation proposed for anosmia (loss of smell) related to COVID-19, we hypothesize that olfactory rehabilitation (using the sense of smell) through the odorous properties of essential oils could be effective for chemotherapy-related taste and smell alterations.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
104

participants targeted

Target at P50-P75 for not_applicable cancer

Timeline
15mo left

Started Aug 2022

Longer than P75 for not_applicable cancer

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress75%
Aug 2022Jul 2027

Study Start

First participant enrolled

August 16, 2022

Completed
2.8 years until next milestone

First Submitted

Initial submission to the registry

June 4, 2025

Completed
23 days until next milestone

First Posted

Study publicly available on registry

June 27, 2025

Completed
1.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 30, 2026

Expected
7 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 30, 2027

Last Updated

June 27, 2025

Status Verified

June 1, 2025

Enrollment Period

4.4 years

First QC Date

June 4, 2025

Last Update Submit

June 19, 2025

Conditions

Cancer

Outcome Measures

Primary Outcomes (1)

  • difference in scores between 6 months and the inclusion at "taste and smell disorders" questionnaire

    taste and smell disorders home-made questionnaire (score from 0 to 100)

    6 months

Study Arms (2)

Control

OTHER

no taste and smell rehabilitation

Other: taste and smell disorders questionnaire

experimental with day hospital

EXPERIMENTAL

During the day hospital, patients will be made aware of the various taste and smell disorders by the medical and paramedical team (doctor, dietician-nutritionist, speech therapist, therapeutic education nurse)

Other: experimental in day hospitalOther: taste and smell disorders questionnaire

Interventions

experimental in day hospitalOTHER

multidisciplinary day hospital

experimental with day hospital
taste and smell disorders questionnaireOTHER

Answer to the home-made questionnaire at inclusion and at 6 months

Controlexperimental with day hospital

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • cancer treated with chemotherapy
  • patient with taste and/or smell disorders

You may not qualify if:

  • patient at the end of chemotherapy treatment

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Médipôle Hôpital Mututaliste

Villeurbanne, 69100, France

RECRUITING

MeSH Terms

Conditions

Neoplasms

Interventions

Taste

Intervention Hierarchy (Ancestors)

SensationNervous System Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
OTHER
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

June 4, 2025

First Posted

June 27, 2025

Study Start

August 16, 2022

Primary Completion (Estimated)

December 30, 2026

Study Completion (Estimated)

July 30, 2027

Last Updated

June 27, 2025

Record last verified: 2025-06

Locations

FR(1)