Impact of Fenugreek Supplementation on Obesity and Hyperglycemia Among Diabetic Adults in Saudi Arabia

NCT07038577 | Completed DMC

• 1 other identifier: UOHail
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to learn if Fenugreek seed powder helps lower body weight and blood sugar in adults with type 2 diabetes who are overweight or obese. The main questions it aims to answer are: Does Fenugreek lower body mass index (BMI)? Does Fenugreek lower fasting blood sugar, random blood sugar, and HbA1c levels? Researchers will compare people who take Fenugreek along with their regular diabetes care to people who receive only standard diabetes care, to see if the Fenugreek supplement adds extra benefits. Participants will: Take 10 grams of Fenugreek seed powder twice a day (before breakfast and dinner) for 3 months. Follow their usual diabetes treatment and a recommended meal plan. Visit the clinic four times during the study to check weight and blood sugar levels. This study is being done in Hail City, Saudi Arabia.

Conditions

Type 2 Diabetes Mellitus (T2DM); Obesity and Type 2 Diabetes; Hyperglycemia

Outcome Measures

Primary Outcomes (1)

• Change in Body Mass Index (BMI)

  BMI will be calculated as weight in kilograms divided by the square of height in meters (kg/m²).

  Baseline and 3 months after intervention

Secondary Outcomes (3)

• Change in Fasting Blood Sugar (FBS)

  Baseline and 3 months after intervention

• Change in Random Blood Sugar (RBS)

  Baseline and 3 months after intervention

• Change in Hemoglobin A1c (HbA1c)

  Baseline and 3 months after intervention

Study Arms (2)

Arm 1: Fenugreek Supplementation

EXPERIMENTAL

40 Participants in this group received 10 grams of Fenugreek seed powder twice daily (before breakfast and dinner) for 3 months, in addition to their usual diabetes treatment and a standard meal plan.

Other: Fenugreek Seed Powder

Arm 2: Standard Care Only

NO INTERVENTION

40 Participants in this group continued their usual diabetes treatment and followed a standard meal plan. They did not receive the Fenugreek supplement.

Interventions

Fenugreek Seed Powder OTHER

Participants in the intervention group received 10 grams of ground Fenugreek seed powder, administered twice daily (before breakfast and dinner), for a total of 3 months. The Fenugreek powder was consumed mixed with water, in addition to the participants' regular antidiabetic medications and a standardized meal plan. The supplement was provided in a non-encapsulated, natural powdered form, and was not combined with any other herbal or pharmaceutical products.

Arm 1: Fenugreek Supplementation

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults aged 18 years or older
• Diagnosed with type 2 diabetes mellitus
• Body Mass Index (BMI) classified as overweight or obese
• Receiving standard diabetes treatment (e.g., oral hypoglycemic agents)
• Able and willing to provide informed consent
• Residing in Hail City, Saudi Arabia

You may not qualify if:

• Diagnosed with type 1 diabetes mellitus
• Currently using insulin therapy
• Pregnant or breastfeeding women
• Known allergy or sensitivity to Fenugreek
• Diagnosed gastrointestinal diseases or malabsorption conditions
• Participation in another clinical trial within the past 3 months
• Any serious medical or psychiatric condition that, in the opinion of the investigators, could interfere with study participation

Sponsors & Collaborators

• University of Hail: lead

Study Sites (1)

University of Hail

Hail, 55424, Saudi Arabia

Location

Related Publications (1)

• Neelakantan N, Narayanan M, de Souza RJ, van Dam RM. Effect of fenugreek (Trigonella foenum-graecum L.) intake on glycemia: a meta-analysis of clinical trials. Nutr J. 2014 Jan 18;13:7. doi: 10.1186/1475-2891-13-7.

  PMID: 24438170 RESULT

Related Links

• Related Info

MeSH Terms

Conditions

Diabetes Mellitus, Type 2; Obesity; Hyperglycemia

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Overweight; Overnutrition; Nutrition Disorders; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Masking Details: All participants, care providers, and investigators were aware of the intervention.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: DR

Model Details: Participants were assigned to one of two parallel groups. One group received Fenugreek seed powder along with standard diabetes treatment, while the other group received standard treatment only. Each participant remained in their assigned group for the full duration of the 3-month study period, with no crossover between groups.

Study Record Dates

• First Submitted: June 9, 2025
• First Posted: June 26, 2025
• Study Start: January 1, 2025
• Primary Completion: May 1, 2025
• Study Completion: June 1, 2025
• Last Updated: June 26, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

SA (1)