Factors Associated With Extubation Failure in Kanigara ICU (Intensive Care Unit) RSUPN Dr. Cipto Mangunkusumo

NCT07038291 | Completed

• 1 other identifier: IndonesiaUAnes1006
• Study Type: observational
• Target: 156
• Locations: 1 country
• Sites: 1

Brief Summary

Extubation is the final stage after patients undergo weaning procedure from mechanical ventilation in the ICU. Extubation failure followed by reintubation is associated with worse patient outcomes, including prolonged length of stay, increased risk of pulmonary infections, need for tracheostomy, higher healthcare costs, and increased mortality. Careful evaluation of various risk factors for extubation failure must be considered, therefore the extubation readiness guideline or checklist is essential before making the decision to extubate. This study aimed to identify factors associated with extubation failure in Kanigara ICU patients. This was a case-control study using secondary data from medical records of ICU patients who underwent extubation between January 2021 until August 2024. Variables analyzed included Glasgow Coma Scale (GCS) score, Arterial Blood Gas (ABG) results, hemodynamics, ventilator settings, airway protection ability, fluid balance, and airway-related problems. Bivariate and multivariate using logistic regression analyses were conducted to identify factors associated with extubation failure.

Conditions

Extubation Failure; Ventilated Patients

Keywords

Extubation failure; ICU; Ventilator

Outcome Measures

Primary Outcomes (1)

• Factors Associated with Extubation Failure analyzed using logistic regression analysis

  Factors assessed were GCS score, hemodynamics, fluid balance, BGA results, airway protection ability, and airway related problems. Data were taken from medical records.

  From January 2021 to August 2025

Study Arms (2)

Extubation Failure

Patient with extubation failure

Other: Not applicable- observational study

Successful Extubation

Patient with successful extubation

Other: Not applicable- observational study

Interventions

Not applicable- observational study OTHER

Observational study without intervention

Extubation Failure; Successful Extubation

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients were intubated in Kanigara ICU for more than 24 hours in January 2021 until August 2024

You may qualify if:

• Patient age 18 years old or more were intubated in Kanigara ICU RSCM more than 24 hours

You may not qualify if:

• Dead or needed tracheostomy before extubation, or reintubated for surgical procedure

Sponsors & Collaborators

• Indonesia University: lead

Study Sites (1)

RSUPN Dr. Cipto Mangunkusumo

Jakarta Pusat, DKI Jakarta, 10430, Indonesia

Location

Related Publications (12)

• Venkategowda PM, Mahendrakar K, Rao SM, Mutkule DP, Shirodkar CG, Yogesh H. Laryngeal air column width ratio in predicting post extubation stridor. Indian J Crit Care Med. 2015 Mar;19(3):170-3. doi: 10.4103/0972-5229.152763.

  PMID: 25810614 BACKGROUND

• Xie J, Cheng G, Zheng Z, Luo H, Ooi OC. To extubate or not to extubate: Risk factors for extubation failure and deterioration with further mechanical ventilation. J Card Surg. 2019 Oct;34(10):1004-1011. doi: 10.1111/jocs.14189. Epub 2019 Aug 2.

  PMID: 31374585 BACKGROUND

• Hazarika A, Singla K, Patel G, Mahajan V, Kahlon S, Meena S. Does Arterial Blood Gas (ABG) Provide a Safety Net for Extubation in Surgical Patients? Cureus. 2023 Jan 9;15(1):e33561. doi: 10.7759/cureus.33561. eCollection 2023 Jan.

  PMID: 36779148 BACKGROUND

• Mokhlesi B, Tulaimat A, Gluckman TJ, Wang Y, Evans AT, Corbridge TC. Predicting extubation failure after successful completion of a spontaneous breathing trial. Respir Care. 2007 Dec;52(12):1710-7.

  PMID: 18028561 BACKGROUND

• Godet T, Chabanne R, Marin J, Kauffmann S, Futier E, Pereira B, Constantin JM. Extubation Failure in Brain-injured Patients: Risk Factors and Development of a Prediction Score in a Preliminary Prospective Cohort Study. Anesthesiology. 2017 Jan;126(1):104-114. doi: 10.1097/ALN.0000000000001379.

  PMID: 27749290 BACKGROUND

• Coplin WM, Pierson DJ, Cooley KD, Newell DW, Rubenfeld GD. Implications of extubation delay in brain-injured patients meeting standard weaning criteria. Am J Respir Crit Care Med. 2000 May;161(5):1530-6. doi: 10.1164/ajrccm.161.5.9905102.

  PMID: 10806150 BACKGROUND

• Tanaka A, Shimomura Y, Uchiyama A, Tokuhira N, Kitamura T, Iwata H, Hashimoto H, Ishigaki S, Enokidani Y, Yamashita T, Koyama Y, Iguchi N, Yoshida T, Fujino Y. Time definition of reintubation most relevant to patient outcomes in critically ill patients: a multicenter cohort study. Crit Care. 2023 Sep 30;27(1):378. doi: 10.1186/s13054-023-04668-3.

  PMID: 37777790 BACKGROUND

• Al-Husinat L, Jouryyeh B, Rawashdeh A, Robba C, Silva PL, Rocco PRM, Battaglini D. The Role of Ultrasonography in the Process of Weaning from Mechanical Ventilation in Critically Ill Patients. Diagnostics (Basel). 2024 Feb 12;14(4):398. doi: 10.3390/diagnostics14040398.

  PMID: 38396437 BACKGROUND

• Andreu MF, Bezzi MG, Dotta ME. Incidence of immediate postextubation complications in critically Ill adult patients. Heart Lung. 2020 Nov-Dec;49(6):774-778. doi: 10.1016/j.hrtlng.2020.09.016. Epub 2020 Sep 24.

  PMID: 32979642 BACKGROUND

• Epstein SK. Decision to extubate. Intensive Care Med. 2002 May;28(5):535-46. doi: 10.1007/s00134-002-1268-8. Epub 2002 Apr 12.

  PMID: 12029399 BACKGROUND

• Arcanjo ABB, Beccaria LM. Factors associated with extubation failure in an intensive care unit: a case-control study. Rev Lat Am Enfermagem. 2023;31:e3864. doi: 10.1590/1518-8345.6224.3864.

  PMID: 36995853 BACKGROUND

• Kulkarni AP, Agarwal V. Extubation failure in intensive care unit: predictors and management. Indian J Crit Care Med. 2008 Jan;12(1):1-9. doi: 10.4103/0972-5229.40942.

  PMID: 19826583 BACKGROUND

Related Links

• Related Info

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of Anesthesiology and Intensive Care Study Program

Study Record Dates

• First Submitted: June 10, 2025
• First Posted: June 26, 2025
• Study Start: March 1, 2025
• Primary Completion: May 30, 2025
• Study Completion: June 5, 2025
• Last Updated: June 26, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

ID (1)