NCT07032623

Brief Summary

This single-blind, randomized controlled trial aims to investigate the effects of spinal manipulation on neuromuscular control in individuals with anterior cruciate ligament reconstruction during a single-leg vertical drop landing task. The intervention group will receive spinal manipulation, while the control group will not receive any therapeutic intervention. The main question it aims to answer is: • Can spinal manipulation induce changes in muscle activation, co-contraction magnitude, and biomechanical parameters during landing?

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
20

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Mar 2025

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

March 3, 2025

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 30, 2025

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

June 3, 2025

Completed
8 days until next milestone

First Submitted

Initial submission to the registry

June 11, 2025

Completed
13 days until next milestone

First Posted

Study publicly available on registry

June 24, 2025

Completed
Last Updated

June 27, 2025

Status Verified

June 1, 2025

Enrollment Period

2 months

First QC Date

June 11, 2025

Last Update Submit

June 24, 2025

Conditions

Keywords

KneeAnterior cruciate ligamentMotor controlElectromyographyPhysiotherapy

Outcome Measures

Primary Outcomes (1)

  • Co-contraction Index

    Outcome measures will be assessed at baseline and 10 minutes post-intervention.

Study Arms (2)

Control

NO INTERVENTION

Spinal Manipulation

EXPERIMENTAL
Procedure: Spinal Manipulation

Interventions

The spinal manipulation will target the sacroiliac joint using the global pelvic manipulation technique. Participants will be positioned in lateral decubitus with the ACL-reconstructed limb placed uppermost. The therapist will apply progressive rotation and flexion at the hip and knee joints to increase tissue tension. To establish contact, the therapist's knee will be placed against the participant's flexed knee. A high-velocity, low-amplitude thrust will then be delivered to optimize joint motion, with cavitation being monitored throughout the procedure.

Spinal Manipulation

Eligibility Criteria

Age18 Years - 55 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64)

You may qualify if:

  • Individuals who have undergone anterior cruciate ligament reconstruction
  • Successful return to recreational sports participation

You may not qualify if:

  • Peripheral or central neurological disorders
  • Systemic or degenerative diseases
  • History of spinal surgery
  • Contraindications to spinal manipulation
  • Low back or sacroiliac pain within the previous month
  • Prior exposure to manipulative therapy

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Center for Rehabilitation Research (CIR), School of Health of Polytechnic of Porto

Porto, Porto District, 4200-604, Portugal

Location

MeSH Terms

Interventions

Manipulation, Spinal

Intervention Hierarchy (Ancestors)

Musculoskeletal ManipulationsPhysical Therapy ModalitiesTherapeuticsRehabilitation

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
BASIC SCIENCE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

June 11, 2025

First Posted

June 24, 2025

Study Start

March 3, 2025

Primary Completion

April 30, 2025

Study Completion

June 3, 2025

Last Updated

June 27, 2025

Record last verified: 2025-06

Locations