Exploring Substance Use, Sleep Disturbances and Reward Sensitivity

NCT07028346 | Not Yet Recruiting

• 1 other identifier: CIRB-2025-173-4
• Study Type: interventional
• Target: 154
• Locations: 0 countries
• Sites: N/A

Brief Summary

According to foreign medical studies, substance use is closely related to reward sensitivity and sleep patterns. The purpose of this research is to understand the relationship between these three factors, which will help improve medical treatment and overall care for substance misuse in the future. Participants will be randomized into CBTi and sleep education groups, and their substance/ alcohol use, sleep parameters and reward sensitivity will be measured at multiple time points.

Conditions

Substance Abuse; Sleep Disturbances

Keywords

Substance abuse; substance misuse; sleep disturbances; sleep problem

Outcome Measures

Primary Outcomes (4)

• Insomnia Severity Index

  From enrollment to the end of treatment at 8 weeks

• Pittsburgh Sleep Quality Index

  From enrollment to the end of treatment at 8 weeks

• Drug Use Disorders Identification Test

  From enrollment to the end of treatment at 8 weeks

• Alcohol Use Disorders Identification Test

  From enrollment to the end of treatment at 8 weeks

Secondary Outcomes (2)

• Sensitivity to Reward Scales from Sensitivity to Reward and Sensitivity to Punishment Questionnaire

  From enrollment to the end of treatment at 8 weeks

• Computerized Iowa Gambling Task

  From enrollment to the end of treatment at 8 weeks

Other Outcomes (1)

• Client Satisfaction Questionnaire (CSQ-8)

  At the end of treatment at 8 weeks

Study Arms (2)

CBTi Group

EXPERIMENTAL

Cognitive Behavioral Therapy for Insomnia

Behavioral: Cognitive Behavioral Therapy for Insomnia

Sleep Education Group

ACTIVE COMPARATOR

Sleep Education

Behavioral: Sleep Education

Interventions

Cognitive Behavioral Therapy for Insomnia BEHAVIORAL

Cognitive Behavioral Therapy for Insomnia (CBT-I) is a first-line, non-medication treatment for insomnia that helps individuals identify and change the thoughts and behaviors that contribute to their sleep problems.

CBTi Group

Sleep Education BEHAVIORAL

Sleep Education group comprises psychoeducation sessions on sleep hygiene.

Sleep Education Group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Individuals who receive treatment services at Substance Abuse Assessment Clinic and other psychiatric out-patient clinics of Kwai Chung Hospital;
• Individuals who have problematic substance or alcohol use in the past 3 months, confirmed by scores higher than or equal to 1 in both part 1 and part 2 of Tobacco, Alcohol, Prescription medication, and other Substance use (TAPS);
• Individuals who have sleep disturbances, confirmed by a score higher than or equal to 8 on the Insomnia Severity Index (ISI).

You may not qualify if:

• Individuals who cannot understand Cantonese, or cannot read Traditional Chinese
• Individuals who cannot provide informed consent due to, for example, intoxication or abnormal mental state
• Individuals who report abnormal or unstable mental states, such as active psychotic symptoms or acute intoxication, at any point of the study
• Individuals who work overnight or have rotating shifts
• Individuals who report pregnancy or medical conditions (including sleep apnea) that may have a severe impact on sleep
• Individuals who use hypnotics regularly

Sponsors & Collaborators

• Kwai Chung Hospital: lead
• The University of Hong Kong: collaborator

MeSH Terms

Conditions

Substance-Related Disorders; Parasomnias

Interventions

Cognitive Behavioral Therapy

Condition Hierarchy (Ancestors)

Chemically-Induced Disorders; Mental Disorders; Sleep Wake Disorders; Nervous System Diseases

Intervention Hierarchy (Ancestors)

Behavior Therapy; Psychotherapy; Behavioral Disciplines and Activities

Central Study Contacts

Mr. Lam

CONTACT

852-2959-8539; fritzyeung@ha.org.hk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Clinical Psychologist

Study Record Dates

• First Submitted: June 11, 2025
• First Posted: June 19, 2025
• Study Start: June 16, 2025
• Primary Completion (Estimated): June 30, 2026
• Study Completion (Estimated): August 31, 2026
• Last Updated: June 24, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share