One Year of Velocity-based Resistance Training in Older People Living in Nursing Homes

NCT07027397 | Completed

• 1 other identifier: 710P
• Study Type: interventional
• Target: 27
• Locations: 1 country
• Sites: 1

Brief Summary

This study is an exercise intervention assessing the efficacy of a velocity-based resistance training (VBRT) in institutionalized older adults. The aim of this study is to assess the effects of one year of velocity-based resistance training on skeletal muscle mass, muscle function, and physical and cognitive function in older adults living in nursing homes.

Conditions

Aging; Muscle Mass and Strength; Muscle Power; Frailty Syndrome; Cognitive Function

Outcome Measures

Primary Outcomes (2)

• Change in muscle power

  Muscle power assessed in leg press machine and sit to stand test.

  T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).

• Changes in neuromuscular performance of lower-body

  Change in the force-velocity relationship in leg press exercise.

  T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).

Secondary Outcomes (6)

• Change in physical function based on the Short Physical Performance Battery score

  T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).

• Change in frailty (score) using Fried's Frailty Criteria and Frailty Trait Scale - Short Form

  T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).

• Change in muscle mass using ultrasonography.

  T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).

• Change in disability using Barthel and Lawton scales

  T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).

• Change in cognitive function using Mini-Mental State Examination

  T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).

Study Arms (1)

Exercise Group

EXPERIMENTAL

a 2-day-a-week resistance training (RT) routine using the velocity-based method in the leg press exercise at 60% of the theoretical maximal isometric strength

Other: Exercise

Interventions

Exercise OTHER

All participants will conduct a 2-day-a-week resistance training (RT) routine using the velocity-based method in the leg press exercise for one year. A tailored and constant intensity will be performed at 60% of the theoretical maximal isometric strength (F0) during the training intervention. Participants will conduct 3-4 sets, individualizing the repetitions numbers until they reach a velocity loss of 10-20%. A rest of 2 minutes was imposed between sets. A standardized warm-up will preced all RT session as follows: 4 minutes walking at usual gait speed and 6 minutes performing dynamic balance exercises.

Exercise Group

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• Older people living permanently in nursing home.
• Age ≥ 65 years old.
• Are able to walk with/without assistance.
• Have ability to communicate with the research team.

You may not qualify if:

• Terminal illness.
• Any illness not controled (cardiac, pulmonary, etc).
• If there is a risk of bone fracture according to medical staff.

Sponsors & Collaborators

• University of Castilla-La Mancha: lead

Study Sites (1)

University of Castilla-La Mancha

Toledo, Toledo, 45071, Spain

Location

MeSH Terms

Conditions

Frailty

Interventions

Exercise

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Julian Alcazar, PhD

  University of Castilla-La Mancha

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD, Associate Professor

Study Record Dates

• First Submitted: May 27, 2025
• First Posted: June 18, 2025
• Study Start: September 30, 2024
• Primary Completion: January 30, 2026
• Study Completion: January 30, 2026
• Last Updated: April 30, 2026

Record last verified: 2026-04

Locations

ES (1)