PRecision biomArker-Guided MAnagement of TuberculosIs Contacts: a Discrete Choice Experiment

NCT07024836 | Recruiting

• 1 other identifier: 175542
• Study Type: observational
• Target: 430
• Locations: 1 country
• Sites: 1

Brief Summary

This study is part of a broader programme of work to develop and pilot a randomised-controlled trial of new tests to identify people who will benefit most from preventive treatment for tuberculosis (TB). The aim of the current study is to explore factors affecting patient decisions to start preventive treatment. The specific objectives are to understand how patients make decisions about preventive treatment initiation for TB (stage 1); and to design and conduct a "discrete choice experiment" survey to further evaluate preferences (stage 2).

Conditions

Tuberculosis (TB)

Keywords

preference; discrete choice experiment; qualitative; latent tuberculosis infection

Outcome Measures

Primary Outcomes (1)

• Preventive treatment acceptance

  Discrete choice experiment data will be analysed to evaluate the primary outcome of preventive TB treatment acceptance in the survey.

  Baseline

Study Arms (3)

Patient participants for qualitative stage (stage 1)

Semi-structured interviews will first be conducted among 20-30 people undergoing testing for latent tuberculosis infection, as part of routine clinical screening programmes (Stage 1).

Patient participants for discrete choice experiment (stage 2)

200 patients will then undertake a quantitative discrete choice experiment to evaluate preferences and trade-offs that influence acceptance of preventive TB treatment.

Healthcare worker participants for discrete choice experiment (stage 2)

200 healthcare workers will also undertake a quantitative discrete choice experiment to evaluate preferences and trade-offs that influence recommendation of preventive TB treatment.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

1. Adults tested, or eligible for testing, for latent tuberculosis infection in routine clinical services. 2. Nurses, doctors or allied health professionals who have any experience of testing or treatment for TB or latent TB infection in UK services.

You may qualify if:

• Adults (aged ≥18 years) who have been tested for latent TB infection in routine clinical services, or are eligible for testing. Eligible people for testing include migrants from countries with high TB incidence (entered UK within 5 years), people with recent contact with a person with TB disease, and people eligible for LTBI screening prior to starting immunosuppression or through occupational health testing.

You may not qualify if:

• Unable to provide informed consent.

Sponsors & Collaborators

• University College, London: lead
• University of Aberdeen: collaborator

Study Sites (1)

Whittington Hospital

London, United Kingdom

RECRUITING

MeSH Terms

Conditions

Tuberculosis; Latent Tuberculosis

Condition Hierarchy (Ancestors)

Mycobacterium Infections; Actinomycetales Infections; Gram-Positive Bacterial Infections; Bacterial Infections; Bacterial Infections and Mycoses; Infections; Latent Infection

Central Study Contacts

Rishi K Gupta, PhD

CONTACT

020 3549 5979; r.gupta@ucl.ac.uk

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 16, 2025
• First Posted: June 17, 2025
• Study Start: May 22, 2025
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: June 17, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will share
• Time Frame: Indefinitely from the time of peer-reviewed publication.
• Access Criteria: The anonymised discrete choice experiment data will be publicly available

Locations

GB (1)