MLPR As A Diagnostic Marker For Acute Pulmonary Embolism

NCT07023705 | Completed

• 1 other identifier: FMASU MLPR 286
• Study Type: observational
• Target: 37
• Locations: 1 country
• Sites: 1

Brief Summary

A retrospective study to assess the utility of hematological marker (monocyte to large platelet ratio) to diagnose patients with pulmonary embolism

Conditions

Pulmonary Embolism (Diagnosis); Diagnosis

Outcome Measures

Primary Outcomes (1)

• Monocyte-to-Large Platelet Ratio (MLPR)

  A ratio between monocyte absolute count and the large platelets count (MLPR) values compared between groups using Mann-Whitney U test; diagnostic accuracy evaluated by area under the curve (AUC) , sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV).

  At emergency department admission (baseline lab measurement) before any treatment.

Secondary Outcomes (5)

• Mean platelet volume (MPV)

  At emergency department admission (baseline lab measurement) before any treatment.

• Neutrophil to Lymphocyte Ratio (NLR)

  At emergency department admission (baseline lab measurement) before any treatment.

• D-Dimer Levels

  At emergency department admission (baseline lab measurement) before any treatment.

• Platelet Distribution Width (PDW)

  At emergency department admission (baseline lab measurement) before any treatment.

• Platelet To Lymphocyte Ratio (PLR)

  At emergency department admission (baseline lab measurement) before any treatment.

Study Arms (2)

Pulmonary embolism

Group that is confirmed to have pulmonary embolism by positive CTPA finding filling defect.

Diagnostic Test: Monocyte to Large Platelet Ratio (MLPR)

Non-Pulmonary embolism

Group that have pulmonary embolism diagnosis was excluded by negative CTPA finding.

Diagnostic Test: Monocyte to Large Platelet Ratio (MLPR)

Interventions

Monocyte to Large Platelet Ratio (MLPR) DIAGNOSTIC_TEST

Admission laboratory values were used to calculate the Monocyte-to-Large Platelet Ratio (MLPR) by dividing the absolute monocyte count by the large platelet count. These values were obtained from blood samples collected before any treatment was administered.

Non-Pulmonary embolism; Pulmonary embolism

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients presenting to the emergency department with signs and symptoms of pulmonary embolism who underwent CT pulmonary angiography for diagnosis.

You may qualify if:

• Only patients with the results of full blood count and white blood cell differentiation, measured before the treatment of suspected PE.
• Patients underwent CT pulmonary angiography to confirm or exclude pulmonary embolism diagnosis.

You may not qualify if:

• Patient with history of any myeloproliferative disorder, myelofibrosis, Glanzmann thrombasthenia, May-Hegglin anomaly, Bernard-Soulier syndrome, suspicion of disseminated intravascular coagulation.
• Patient receiving any anticoagulant drug at a therapeutic dose.
• Patient with blood transfusion in the last 2 months.
• Patients with acute coronary syndrome, pulmonary edema.
• Patient on immunosuppressive drugs , Oral contraceptive pills .
• Patients with severe renal or hepatic disease.
• Patients with Stroke.
• Patients with malignancy.

Sponsors & Collaborators

• Ain Shams University: lead

Study Sites (1)

Ain Shams University

Cairo, Egypt

Location

Related Publications (4)

• Granger V, Faille D, Marani V, Noel B, Gallais Y, Szely N, Flament H, Pallardy M, Chollet-Martin S, de Chaisemartin L. Human blood monocytes are able to form extracellular traps. J Leukoc Biol. 2017 Sep;102(3):775-781. doi: 10.1189/jlb.3MA0916-411R. Epub 2017 May 2.

  PMID: 28465447 BACKGROUND

• Moharamzadeh P, Rahmani F, Foroughifar S, Shahsavarinia K. Reliability of Platelet Indices for Diagnosing Pulmonary Embolism; a Brief Report. Adv J Emerg Med. 2019 Apr 28;3(3):e27. doi: 10.22114/ajem.v0i0.137. eCollection 2019 Summer.

  PMID: 31410404 BACKGROUND

• Talay F, Ocak T, Alcelik A, Erkuran K, Akkaya A, Duran A, Demirhan A, Kar Kurt O, Asuk Z. A new diagnostic marker for acute pulmonary embolism in emergency department: mean platelet volume. Afr Health Sci. 2014 Mar;14(1):94-9. doi: 10.4314/ahs.v14i1.15.

  PMID: 26060464 BACKGROUND

• Bialas AJ, Kornicki K, Ciebiada M, Antczak A, Sitarek P, Milkowska-Dymanowska J, Piotrowski WJ, Gorski P. Monocyte to large platelet ratio as a diagnostic tool for pulmonary embolism in patients with acute exacerbation of chronic obstructive pulmonary disease. Pol Arch Intern Med. 2018 Jan 31;128(1):15-23. doi: 10.20452/pamw.4141. Epub 2017 Nov 7.

  PMID: 29112185 RESULT

MeSH Terms

Conditions

Pulmonary Embolism; Disease

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Embolism; Embolism and Thrombosis; Vascular Diseases; Cardiovascular Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Reem H Elkabarity, Professor

  Ain Shams University

  STUDY CHAIR

• Hadil M Abdelhamid, Professor

  Ain Shams University

  STUDY DIRECTOR

• Azza Lotfy, Professor

  Ain Shams University

  STUDY DIRECTOR

• Mohamed k Awad, Lecturer

  Ain Shams University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Lecturer

Study Record Dates

• First Submitted: June 9, 2025
• First Posted: June 17, 2025
• Study Start: January 1, 2024
• Primary Completion: December 31, 2024
• Study Completion: May 31, 2025
• Last Updated: June 19, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)