Study on Screening Strategies for Interstitial Lung Abnormalities and Airway Lesions

NCT07023575 | Not Yet Recruiting DMC

• 1 other identifier: 2024ZD0522301
• Study Type: observational
• Target: 100,000
• Locations: 1 country
• Sites: 10

Brief Summary

The goal of this observational study is to learn about the comorbidity patterns of interstitial and airway abnormalities in adults undergoing health examinations in China. The main questions it aims to answer are: How do early interstitial lung abnormalities progress to comorbid interstitial and airway diseases? What are the key factors associated with this progression? Participants undergoing routine health examinations will be assessed for interstitial and airway abnormalities based on imaging and clinical data. Longitudinal follow-up will be used to evaluate disease progression and identify associated risk factors.

Conditions

Interstitial Lung Abnormalities

Keywords

interstitial lung abnormalities

Outcome Measures

Primary Outcomes (1)

• high-resolution computed tomography (HRCT) examinations

  through study completion, an average of 1 year

Study Arms (1)

Chinese Routine Chest CT Health Examination Cohort

This group includes individuals who underwent routine health examinations with chest CT imaging at participating health checkup centers across China between 2017 and 2024. Participants may have one or more CT records, and no interventions were applied as part of the study. This group will be analyzed for the presence of interstitial lung abnormalities and/or airway diseases based on imaging and lung function data, as well as demographic and clinical characteristics.

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants were recruited from multiple health checkup centers across various regions of China between 2017 and 2024. Specifically, this retrospective study included data from 10 hospital-based health examination institutions located within the four major economic regions of China (East, Central, West, and Northeast). All available health examination records of individuals who underwent chest CT scans during this period were collected for analysis.

You may qualify if:

• Underwent chest CT examination between January 1, 2017 and December 31, 2024
• Age 18 years or older at the time of examination

You may not qualify if:

• \- Missing or incomplete key demographic or imaging information (e.g., missing date of examination, sex, age, or CT report)

Sponsors & Collaborators

• China-Japan Friendship Hospital: lead

Study Sites (10)

China-Japan Friendship Hospital

Beijing, Beijing Municipality, China

Location

Zhongshan Hospital, Fudan University

Shanghai, Shanghai Municipality, China

Location

Zhongguancun Meinian Health Industry Research Institute

Beijing, China

Location

Central South University

Changsha, China

Location

Affiliated Hospital of Guizhou Medical University

Guiyang, China

Location

Zhejiang University

Hangzhou, China

Location

Henan Provincial People's Hospital

Henan, China

Location

The Affiliated Hospital of Qingdao University

Qingdao, China

Location

The First Affiliated Hospital of China Medical University

Shenyang, China

Location

Henan Hongli Hospital Co., Ltd

Xinxiang, China

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Chief Physician

Study Record Dates

• First Submitted: June 8, 2025
• First Posted: June 17, 2025
• Study Start: August 1, 2025
• Primary Completion (Estimated): November 30, 2028
• Study Completion (Estimated): November 30, 2028
• Last Updated: June 17, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

CN (10)