NCT07023146

Brief Summary

Power (strength Ă— velocity) is a crucial component for maintaining independence during aging. Therefore, investigating interventions aimed at improving this physical capacity is essential for this population. The aim of this study is to examine the effects of power training (PT) performed at low to moderate intensity (PTLM; 40-60% of 1-repetition maximum \[1RM\]) and moderate to high intensity (PTMH; 65-80% of 1RM) on muscle power, kinematic gait parameters, strength, muscle thickness, and functional performance in older adults. Participants will be randomly assigned to perform PTLM and PTMH. Data collection will occur before and after familiarization, as well as at weeks 8 and 16 of the training programs. Participants will undergo a series of tests in the following sequence: 1) muscle thickness and 1RM test; 2) muscle power, maximum voluntary contraction, and rate of force development; 3) functional performance. The primary analyses will be conducted on an intention-to-treat basis, comparing the effects of the interventions and groups over time. Generalized Estimating Equations (GEE) will be used, considering the factors of group (2 levels) and time (3 levels). Paired comparisons will be assessed using the Bonferroni post-hoc test to identify significant differences between groups and time points. All tests will be performed using JASP software (version 0.16.4.0), with statistical significance set at p \< 0.05 for all analyses.

Trial Health

55
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
70

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Apr 2025

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
enrolling by invitation

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 2, 2025

Completed
2 months until next milestone

First Submitted

Initial submission to the registry

May 23, 2025

Completed
23 days until next milestone

First Posted

Study publicly available on registry

June 15, 2025

Completed
6 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 11, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 11, 2025

Completed
Last Updated

June 15, 2025

Status Verified

June 1, 2025

Enrollment Period

8 months

First QC Date

May 23, 2025

Last Update Submit

June 7, 2025

Conditions

Keywords

Agingresistance trainingfunctional capacitymuscle strengthmuscle hypertrophy

Outcome Measures

Primary Outcomes (3)

  • Muscle Power

    The power output during strength exercises is assessed using an encoder linear at two different intensities: 30% and 70% of 1RM in leg extension and leg press 45. Power output is the ability to generate force quickly and is a key measure of explosive strength. These tests are performed using different resistance levels to assess power across a range of intensities. Measurement Tool: Encoder linear (linear encoder or velocity-based device) Scale: Power output in watts (W) Higher scores indicate better power performance at each intensity.

    Pre- and post-intervention (16 weeks of training)

  • Muscle Strength

    Muscle strength is the ability of a muscle or muscle group to generate force against resistance. It reflects the maximum force that can be produced in a single effort and is essential for daily activities and overall physical function. One Repetition Maximum (1RM) is used to quantify maximal strength. Measurement Tool: 1RM testing Scale: 1RM (measured in kg) Higher scores indicate better strength performance.

    Pre- and post-intervention (16 weeks of training)

  • Rate of Force Development

    Rate of force development refers to the speed at which force is generated by a muscle or muscle group. It is a critical measure of neuromuscular performance, especially in activities that require explosive strength or rapid reactions. RFD is measured during maximal voluntary contractions. Measurement Tool: Load Cell Scale: Measured in Newtons per second (N/s) Higher scores indicate better neuromuscular performance.

    Pre- and post-intervention (16 weeks of training)

Secondary Outcomes (3)

  • Functional Capacity

    Pre- and post-intervention (16 weeks of training)

  • Muscle hypertrophy

    Pre- and post-intervention (16 weeks of training)

  • Cognitive Capacity

    Pre- and post-intervention (16 weeks of training)

Study Arms (2)

Low to moderate intensity (PTLM; 40-60% of 1-repetition maximum [1RM])

ACTIVE COMPARATOR

Power training performed at maximum velocity in the concentric phase with lower to moderate intensity

Device: low to moderate intensity (PTLM; 40-60% of 1-repetition maximum [1RM])

Moderate to high intensity (PTMH; 65-80% % of 1-repetition maximum [1RM])

ACTIVE COMPARATOR

Power training performed at maximum velocity in the concentric phase with moderate to high intensity

Device: Moderate to high intensity (PTMH; 65-80% of 1-repetition maximum [1RM]) )

Interventions

Power training performed at maximum velocity in the concentric phase with moderate to high intensity

Also known as: PTMH, Linear Encoder, Load Cell, 1-Repetition Maximum (1RM), Ultrasound
Moderate to high intensity (PTMH; 65-80% % of 1-repetition maximum [1RM])

Power training performed at maximum velocity in the concentric phase with lower to moderate intensity

Also known as: PTLM, Linear Encoder, 1-Repetition Maximum (1RM), Ultrasound, Load Cell
Low to moderate intensity (PTLM; 40-60% of 1-repetition maximum [1RM])

Eligibility Criteria

Age60 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age 60 years or older
  • No participation in regular and systematic resistance training in the last three months
  • No absolute or relative contraindications to exercise
  • No musculoskeletal injuries that could interfere with training and assessments

You may not qualify if:

  • Use of steroids, nutritional supplements, or ergogenic substances
  • Failure to complete all study phases
  • Failure to complete more than 80% of the training sessions (32 sessions)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Universidade Federal do Rio Grande do Sul (UFRGS)

Porto Alegre, Rio Grande do Sul, 91410-070, Brazil

Location

Related Publications (4)

  • Martinikorena I, Martinez-Ramirez A, Gomez M, Lecumberri P, Casas-Herrero A, Cadore EL, Millor N, Zambom-Ferraresi F, Idoate F, Izquierdo M. Gait Variability Related to Muscle Quality and Muscle Power Output in Frail Nonagenarian Older Adults. J Am Med Dir Assoc. 2016 Feb;17(2):162-7. doi: 10.1016/j.jamda.2015.09.015. Epub 2015 Nov 11.

    PMID: 26577625BACKGROUND
  • Mc Dermott EJ, Balshaw TG, Brooke-Wavell K, Maden-Wilkinson TM, Folland JP. Fast and ballistic contractions involve greater neuromuscular power production in older adults during resistance exercise. Eur J Appl Physiol. 2022 Jul;122(7):1639-1655. doi: 10.1007/s00421-022-04947-x. Epub 2022 Apr 16.

    PMID: 35429294BACKGROUND
  • Bandeira-Guimaraes M, Blanco-Rambo E, Vieira AF, Saez de Asteasu ML, Pinto RS, Izquierdo M, Cadore EL. Chronic Effects of Different Intensities of Power Training on Neuromuscular Parameters in Older People: A Systematic Review with Meta-analysis. Sports Med Open. 2023 Oct 24;9(1):98. doi: 10.1186/s40798-023-00646-9.

    PMID: 37874417BACKGROUND
  • de Vos NJ, Singh NA, Ross DA, Stavrinos TM, Orr R, Fiatarone Singh MA. Optimal load for increasing muscle power during explosive resistance training in older adults. J Gerontol A Biol Sci Med Sci. 2005 May;60(5):638-47. doi: 10.1093/gerona/60.5.638.

    PMID: 15972618BACKGROUND

Related Links

MeSH Terms

Interventions

Ultrasonography

Intervention Hierarchy (Ancestors)

Diagnostic ImagingDiagnostic Techniques and ProceduresDiagnosis

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
TRIPLE
Who Masked
PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
Purpose
PREVENTION
Intervention Model
PARALLEL
Model Details: The methodological procedures of this project will be carried out at the UFRGS facilities, on the campus of the School of Physical Education, Physiotherapy and Dance (ESEFID) and at LAPEX. After two weeks of familiarization, in order to guarantee the reproducibility and reliability of the methodological procedures, the participants will be randomized electronically (randomizer.org.br) to perform low to moderate intensity (PTLM; 40-60% of 1-repetition maximum \[1RM\]) and moderate to high intensity (PTMH; 65-80% of 1RM).
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Doctor Student

Study Record Dates

First Submitted

May 23, 2025

First Posted

June 15, 2025

Study Start

April 2, 2025

Primary Completion

December 11, 2025

Study Completion

December 11, 2025

Last Updated

June 15, 2025

Record last verified: 2025-06

Data Sharing

IPD Sharing
Will not share

Locations