Matrix Rotation Flap Versus Single Incision Lateral Sulcus Mammoplasty

NCT07022509 | Completed

• 2 other identifiers: RC 9-4-2022PNURSP2025R168
• Study Type: interventional
• Target: 64
• Locations: 1 country
• Sites: 1

Brief Summary

The study seeks to compare the single-incision lateral mammoplasty technique with the matrix rotation flap in patients with breast carcinoma. The primary outcome assessed is postoperative complications, while secondary outcomes include cosmetic appearance and patient satisfaction.

Conditions

Breast Cancer Early Stage Breast Cancer (Stage 1-3)

Keywords

breast cancer; Oncology; MRF; SLIM

Outcome Measures

Primary Outcomes (1)

• Postoperative complications

  The total number (percentage) of participants in each group who got post-operative complications such as wound infection, hematoma, and seroma.

  4 weeks

Secondary Outcomes (2)

• Asthetic outcomes

  6 months

• Patients' satisfaction

  6 months

Study Arms (2)

Group MRF

EXPERIMENTAL

Matrix rotation flap MRF surgical procedure

Other: Technique surgery

Group SLIM

EXPERIMENTAL

Single Incision Lateral Sulcus Mammoplasty (SLIM).

Other: proceduder surgery

Interventions

proceduder surgery OTHER

The single-incision lateral sulcus mammoplasty is a breast-conserving surgical technique that involves making a single incision along the lateral aspect of the inframammary fold or within the natural skin crease of the lateral sulcus. This approach provides direct access to the lateral quadrants of the breast, which are commonly affected in breast carcinoma, allowing for effective tumor excision while preserving the breast contour. In SILSM, the incision is carefully planned to align with natural anatomical lines, ensuring optimal cosmetic results and minimal visible scarring. Through this lateral access point, the surgeon performs both tumor resection and glandular reshaping. The technique often involves mobilization and rearrangement of the remaining breast tissue to fill the defect left by the tumor excision, thereby maintaining breast symmetry and volume. This techn

Group SLIM

Technique surgery OTHER

The matrix rotation flap is a versatile oncoplastic surgical technique employed in the reconstruction of partial breast defects following tumor excision. This method involves the creation of a rotational skin and glandular flap, mobilized from adjacent breast tissue, typically using an inferolateral or inferomedial pedicle. The flap is designed in a curvilinear or semicircular fashion, allowing it to rotate into the defect site while maintaining adequate vascular supply. The MRF technique is particularly useful for defects in the lower quadrants of the breast, where direct tissue advancement may be limited. The surgeon carefully outlines a skin paddle adjacent to the resection cavity and undermines the surrounding breast parenchyma. The flap is then rotated and inset into the tumor bed to fill the defect, with the skin paddle contributing to both volume replacement and skin resurfacing if required. This approach provides robust coverage of the surgical cavity, helps restore breast co

Group MRF

Eligibility Criteria

• Age: 42 Years - 61 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Upper Quadrant Breast Carcinomas.

You may not qualify if:

• Patients with T4 tumors, inflammatory breast cancer and distant metastasis, multi-centric breast cancer in more than one quadrant and diffuse microcalcifications were excluded from the study.

Sponsors & Collaborators

• Batterjee Medical College: lead

Study Sites (1)

Faculty of Medicine, Benha University, Benha, Egypt

Giza, Cairo Governorate, 13511, Egypt

Location

Related Publications (1)

• Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019 Jan;69(1):7-34. doi: 10.3322/caac.21551. Epub 2019 Jan 8.

  PMID: 30620402 BACKGROUND

Related Links

• pubmed official site

MeSH Terms

Conditions

Breast Neoplasms; Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by Site; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, CARE PROVIDER
• Masking Details: Statisticians
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: May 30, 2025
• First Posted: June 15, 2025
• Study Start: May 7, 2022
• Primary Completion: December 17, 2023
• Study Completion: June 1, 2024
• Last Updated: June 15, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)