Oral Health Condition Among a Group of Ionizing Radiation Field Workers

NCT07020078 | Not Yet Recruiting

• 1 other identifier: MustansiriyahU
• Study Type: observational
• Target: 90
• Locations: 0 countries
• Sites: N/A

Brief Summary

The goal of this study is to test the effect of ionizing radiation on salivary Redox status among a group of ionizing radiation workers by measuring salivary biomarkers(malondialdehyde,8\_hydroxy\_deoxyguanosine and catalase) and measuring oral health condition by plaque index. 90 male subjects will be enrolled in this study between 30\_40 years old worked in Baghdad teaching hospital ,30 subjects exposed from computed tomography department ,30 subjects exposed from x\_ray department and 30 subjects unexposed from laboratory department in the same hospitals. The method of the study is taking unstimulated saliva sample from the subjects and oral health measure.

Conditions

Salivary Redox Biomarkers and Oral Health

Outcome Measures

Primary Outcomes (1)

• oral health status

  Changes in the clinical periodontal parameter (Plaque index ) To determine the patients' plaque index, their dental plaque thickness was evaluated by probing the mesial, distal, buccal, and palatal surfaces of all teeth using a Williams periodontal probe. The individual's plaque index was determined by summing the values obtained for each tooth and calculating the averages.Silness \& Löe (Silness \& Löe,1964) reference values were taken as a basis The Plaque Index (PI) scores each site on a 0 to 3 scale Score 0 : No plaque is in the area adjacent to the gingiva. Score 1: There is a plaque in the form of a thin film on the gingival margin. Score 2: There is a visible plaque in the gingival pocket and gingival margin. Score 3: There is a dense plaque in the gingival pocket and on the gingival margin.

  Baseline: the subjects must be fasting. up to two hours saliva collection

Secondary Outcomes (3)

• Salivary Malondialdehyde biomarker

  Baseline:saliva collection for malondialdehyde . up to two hours fasting for all subjects.

• Salivary 8_ hydroxy_deoxyguanosine biomarker

  Baseline:saliva collection for 8_hydroxy_deoxyguanosine .up to two hours fasting for all subjects.

• Salivary catalase biomarker

  Baseline:saliva collection for catalase . up to two hours fasting for all subjects.

Interventions

Salivary redox biomarkers RADIATION

Salivary redox biomarkers

Eligibility Criteria

• Age: 30 Years - 40 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Male workers in radiation field from 30\_40 years old who exposed to radiation for 5\_10 years and compare them with male workers in laboratory at age 30\_40 years

You may qualify if:

• male, 30\_40 years ,no history of systemic disease, no medical treatment taken at least 3 months before sampling and the subjects are exposed to radiation 5\_ 10 years

You may not qualify if:

• subjects with medical history , subjects are taken medications during last 3 months , the subjects are exposed to radiation less than 5 years or more than 10 years

Sponsors & Collaborators

• Al-Mustansiriyah University: lead

Central Study Contacts

Jihan Munther Hussien, B.D.S

CONTACT

+9647719770649; jihanmunther@uomustansiriyah.edu.iq

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Master student

Study Record Dates

• First Submitted: May 4, 2025
• First Posted: June 13, 2025
• Study Start: June 25, 2025
• Primary Completion: July 25, 2025
• Study Completion: August 25, 2025
• Last Updated: June 13, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share