BDNF Levels in Cancer Patients Receiving Chemotherapy

NCT07019324 | Active Not Recruiting

• 1 other identifier: TKB-2025-5052
• Study Type: observational
• Target: 75
• Locations: 1 country
• Sites: 1

Brief Summary

Cognitive impairment following chemotherapy is defined as chemotherapy-induced cognitive impairment (CCIID). CCIID, which significantly reduces the quality of life of cancer patients receiving chemotherapy, develops as a result of neurotoxicity. It is stated that 75% of patients receiving chemotherapy have cognitive changes. In addition, 35% of patients complain of various cognitive impairments (hearing, perception, decision-making, etc.) for a few months after chemotherapy ends. This situation makes life conditions very difficult for patients who are already experiencing a very difficult disease and treatment process. Brain-Derived Neurotrophic Factor (BDNF) is an extracellular signaling protein known for its dominant role in the development of the nervous system, such as neurogenesis, neuroprotection, neurodegeneration, synaptic plasticity, and resistance to neuronal stress. This protein has opposing effects with its mature form, pro-BDNF protein, and pro-BDNF/BDNF ratios affect neuronal health. Although a number of factors have been identified that are responsible for the deterioration of the cognitive levels of patients receiving chemotherapy, the role of BDNF and pro-BDNF levels in cognitive functions in cancer patients receiving chemotherapy is unknown. In light of this information, the aim of our study is to reveal the effects of chemotherapy-induced cognitive impairment (CIID) on pro-BDNF/BDNF levels and to evaluate the cognitive effects. In line with this aim, patients who apply to Çanakkale Onsekiz Mart University, Faculty of Medicine, Department of Oncology, Polyclinic and Chemotherapy Unit and who have not yet received their first chemotherapy will be included in the study. Before the first chemotherapy, during routine follow-ups in the 3rd month of chemotherapy and in the 6th month in Aydın, 1 extra tube of blood will be taken and BDNF levels will be examined. At the same time, the Montreal Cognitive Assessment (MoCA) test will be applied to the patients to evaluate their cognitive functions. Thus, serum BNDF, proBDNF levels will be determined and the BDNF/proBDNF ratio will be revealed.

Conditions

BDNF; Cognitive Functions; Chemotherapy

Outcome Measures

Primary Outcomes (1)

• BDNF level

  BDNF level from every 3 months

  Until 9 month

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Applying Çanakkale Onsekiz Mart University Oncology Department

You may qualify if:

• Cancer definations and decided the chemotherapy treatment

You may not qualify if:

• Having other disease whixh effected cognitive function
• Brain cancers
• Brain metastasis

Sponsors & Collaborators

• Cemre Aydeğer: lead

Study Sites (1)

Çanakkale Onsekiz Mart University

Çanakkale, Merkez, 17020, Turkey (Türkiye)

Location

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Çanakkale Onsekiz Mart University

Study Record Dates

• First Submitted: June 5, 2025
• First Posted: June 13, 2025
• Study Start: March 17, 2025
• Primary Completion (Estimated): June 4, 2026
• Study Completion (Estimated): June 4, 2026
• Last Updated: June 13, 2025

Record last verified: 2025-01

Locations

TU (1)