Hypoxia Adaptation Promotes Cerebral Functional Connectivity With Neuromuscular Efficiency Decrement

NCT07018817 | Completed DMC

• 1 other identifier: Brain Adaptation to Hypoxia
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

The study utilized a trimodal setup comprising EEG, EMG, and fNIRS modules. Participants wore a 64-channel dry EEG cap, while EMG electrodes were placed on the right biceps brachii, the flexor digitorum profundus of the forearm, and the gastrocnemius muscle. fNIRS probes were positioned on the forehead to monitor cerebral hemodynamic responses. The experimental paradigm included two tasks: motor execution (ME) and motor imagery (MI). During ME, participants performed 15 trials of actual movements. In MI, participants completed 60 trials of imagined movements. Each trial involved a randomly presented stimulus-left-hand clenching, right-hand clenching, or bilateral heel raising-with each movement type occurring an equal number of times across the session.

Conditions

Hypoxia; Altitude Sickness

Keywords

Brain

Outcome Measures

Primary Outcomes (1)

• EEG Power Spectrum in Motor Imagery and Motor Execution Tasks

  up to 2 weeks

Secondary Outcomes (2)

• Surface EMG Amplitude of Upper Limb Muscles during Motor Tasks

  up to 2 weeks

• Cerebral Oxygenation Measured by Near-Infrared Spectroscopy (NIRS) in Prefrontal Cortex

  up to 2 weeks

Interventions

motor execution motor imagery BEHAVIORAL

Participants will perform motor execution tasks and motor imagery tasks following standardized instructions under controlled conditions.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Short-term migration from the highlands

You may qualify if:

• People who can withstand altitude sickness

You may not qualify if:

• Plateau Native

Sponsors & Collaborators

• Peking Union Medical College: lead

Study Sites (1)

Institute of Biomedical engineering，Chinese Academy of Medical Sciences & Peking Union Medical College

Tianjin, Tianjin Municipality, 300000, China

Location

Related Links

• Related Info

MeSH Terms

Conditions

Hypoxia; Altitude Sickness

Condition Hierarchy (Ancestors)

Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Respiration Disorders; Respiratory Tract Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Full professor

Study Record Dates

• First Submitted: April 27, 2025
• First Posted: June 13, 2025
• Study Start: July 15, 2023
• Primary Completion: August 23, 2024
• Study Completion: December 15, 2024
• Last Updated: June 13, 2025

Record last verified: 2025-04

Locations

CN (1)