PAPE Effect With Blood Flow Restriction and Push-Up Exercise (Post-Activation Performance Enhancement)

NCT07015515 | Completed

• 1 other identifier: PAPE-BFR-2025
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to compare the acute effects of push-up exercises performed under different blood flow restriction (BFR) conditions on upper extremity explosive strength performance, measured via the seated unilateral medicine ball throw test.

Conditions

Blood Flow Restriction Exercise

Keywords

BFR; push-up exercise; PAPE; radar measurement; explosive power

Outcome Measures

Primary Outcomes (1)

• throw distance

  Seated unilateral medicine ball throw distance (in cm) -

  will be measured immediately after the exercise protocol is completed three times at 4th, 8th, and 12th minutes

Secondary Outcomes (2)

• Ball velocity (km/h)

  will be measured by radar device after completion of the exercise three times at 4th, 8th, and 12th minutes

• Rating of Perceived Exertion (RPE)

  1 day (will be assessed at the end of the push-up exercise)

Study Arms (3)

Blood flow restriction exercise group

EXPERIMENTAL

Participants will perform push-up exercises with 50% arterial occlusion pressure applied to their dominant arm. The cuff is inflated before the exercise and maintained throughout 3 sets of 5 repetitions. There is a 2-minute rest between sets.

Other: Blood flow restriction exercise group

Sham Blood flow restriction exercise group

PLACEBO COMPARATOR

In this group, a BFR cuff will be placed on the upper extremity in the same location as in the real BFR group. During the application, the participant will be led to believe that the cuff is being inflated, although no actual pressure will be applied. The participant will see the cuff being wrapped and apparently inflated, but there will be no physical pressure restricting circulation during the exercise. This aims to control the psychological effects (e.g., the belief that "something is being applied") on performance.

Other: Sham blood flow restriction exercise

Control group

ACTIVE COMPARATOR

Participants perform push-up exercises without any cuff application. The same repetition and rest protocol is followed.

Other: Control group

Interventions

Sham blood flow restriction exercise OTHER

a BFR cuff will be placed on the upper extremity in the same location as in the real BFR group. During the application, the participant will be led to believe that the cuff is being inflated, although no actual pressure will be applied. The participant will see the cuff being wrapped and apparently inflated, but there will be no physical pressure restricting circulation during the exercise. This aims to control the psychological effects (e.g., the belief that "something is being applied") on performance

Sham Blood flow restriction exercise group

Control group OTHER

Participants perform push-up exercises without any cuff application. The same repetition and rest protocol is followed

Control group

Blood flow restriction exercise group OTHER

Participants will perform push-up exercises with 50% arterial occlusion pressure applied to their dominant arm. The cuff is inflated before the exercise and maintained throughout 3 sets of 5 repetitions. There is a 2-minute rest between sets.

Blood flow restriction exercise group

Eligibility Criteria

• Age: 18 Years - 25 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Being between 18 and 25 years old
• Being a volleyball player
• Having trained regularly in the last 6 months
• Ability to perform at least 5 repetitions of push-up with own body weight
• Voluntarily agreeing to participate and signing the informed consent form

You may not qualify if:

• History of shoulder or upper extremity injury requiring physical therapy or surgery
• History of venous thromboembolism
• Hematological disorders
• Coronary artery disease
• Peripheral arterial disease
• Hypertension (systolic/diastolic \> 140 mmHg/90 mmHg)
• History or high risk of deep vein thrombosis
• Blood clotting disorders
• Poor circulation
• Inadequate lymphatic system
• History of endothelial dysfunction
• Varicose veins
• Peripheral vascular disease
• Diabetes
• Easy bruising

Sponsors & Collaborators

• Istanbul University: lead

Study Sites (1)

Istanbul Faculty of Medicine

Istanbul, 34093, Turkey (Türkiye)

Location

MeSH Terms

Interventions

Control Groups

Intervention Hierarchy (Ancestors)

Epidemiologic Research Design; Epidemiologic Methods; Investigative Techniques; Research Design; Methods

Study Officials

• Şensu Dinçer

  Istanbul University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: May 30, 2025
• First Posted: June 11, 2025
• Study Start: June 20, 2025
• Primary Completion: August 20, 2025
• Study Completion: August 20, 2025
• Last Updated: November 18, 2025

Record last verified: 2025-11

Locations

TU (1)