Applying a Multidisciplinary Intervention for Drug Adequacy in an Intermediate Care Hospital (AMIDA-ICH)

NCT07015112 | Recruiting

• 1 other identifier: AMIDA-ICH
• Study Type: interventional
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this clinical trial is to learn if a multi-professional (conducted by geriatricians, clinical pharmacists, nurses) medication revision, centered on patients' goals and characteristics, can improve treatment adequacy in older adults admitted to an intermediate care hospital. The main question it aims to answer is: does this approach reduce the average number of medications taken per patient? Researchers will compare this multi-professional patient-centered revision to the usual standard of care (treatment revision conducted by a clinical pharmacist) to see if the patient-centered revision works in improving treatment adequacy. Participants admitted to an intermediate care hospital will undergo a comprehensive assessment by a geriatrician, and a medication revision (conducted by a multidisciplinary team or a clinical-pharmacist alone). They will also be asked to fulfill some questionnaires on their health status and attitudes. Any possible adverse events to the medications will be recorded at discharge. Participants will be contacted again three months after discharge to check for any readmission or death.

Conditions

Poly Pharmacy; Frail Elderly

Keywords

polypharmacy; frailty; adverse drug event; deprescribing

Outcome Measures

Primary Outcomes (1)

• Number of drugs

  Median number of drugs per patient

  Baseline and after discharge, an average of 30 days

Study Arms (2)

Control (usual care)

NO INTERVENTION

Control arm will receive usual standard of care

Intervention (patient-centered medication review)

EXPERIMENTAL

Intervention arm will receive a multidisciplinary patient-centered medication review

Other: Patient-centered multidisciplinary treatment review

Interventions

Patient-centered multidisciplinary treatment review OTHER

Patient-centered multidisciplinary treatment review is defined as a medication review conducted by a multidisciplinary team (geriatrician, clinical pharmacist, nurse) according to a patient-centered methodology, based on person-centered evaluation of both personal and clinical insights, diagnostic-centered evaluation (based on current guidelines), and drug-centered evaluation (based on adequacy)

Intervention (patient-centered medication review)

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• older adults (65+ years)
• ≥ 3 or more chronic conditions requiring medical therapy
• able to speak Spanish
• capacity to provide informed consent or have a surrogate able to consent on their behalf

You may not qualify if:

• unable to provide informed consent
• anticipated length of hospital stay \< 72h
• estimated life expectancy \< 3 months
• homeless
• already enrolled in a drug trial

Sponsors & Collaborators

• Parc Sanitari Pere Virgili: lead

Study Sites (1)

Parc Sanitari Pere Virgili

Barcelona, Barcelona, 08023, Spain

RECRUITING

MeSH Terms

Conditions

Frailty; Drug-Related Side Effects and Adverse Reactions

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms; Chemically-Induced Disorders

Central Study Contacts

Ana M de Andrés Lázaro, Pharmacist. PhD

CONTACT

+34932594128; amandres@perevirgili.cat

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Stepped-wedge

Study Record Dates

• First Submitted: June 1, 2025
• First Posted: June 11, 2025
• Study Start: January 4, 2024
• Primary Completion: December 1, 2025
• Study Completion (Estimated): June 1, 2026
• Last Updated: June 11, 2025

Record last verified: 2025-06

Locations

ES (1)