Fight Fatigue: A Progressive Muscle Relaxation and Walking Intervention to Reduce Fatigue in Adults With ESKD

NCT07014111 | Recruiting

• 2 other identifiers: STUDY2025-0281R34AT012770
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Fight Fatigue is evaluating the feasibility and acceptability of a combined progressive muscle relaxation and walking intervention to reduce fatigue for adults with end-stage kidney disease receiving in-center hemodialysis.

Conditions

End Stage Renal Disease on Dialysis

Keywords

Fatigue

Outcome Measures

Primary Outcomes (4)

• Feasibility of recruitment

  Recruitment metrics (enrolled/invited)

  Baseline to week 12

• Feasibility of retention

  Retention in the study from baseline to week 12

  Baseline to week 12

• Acceptability

  Participant rating of acceptability (e.g., enjoyable, easy to understand) via Likert scale questions and open ended questions

  End of study (Week 12)

• Adherence to the study protocol

  Adherence to the intervention measured with adherence to step counts, number/duration of accesses on the study-specific website, and adherence to study procedures as evaluated with number of text messages read/sent messages read.

  Baseline to week 12

Other Outcomes (1)

• Fatigue

  Baseline to week 12

Study Arms (2)

Fight Fatigue

EXPERIMENTAL

Combined progressive muscle relaxation and walking (increasing step count) 12-week intervention that consists of education/training followed by text messages

Behavioral: Fight Fatigue

Attention Control

ACTIVE COMPARATOR

End-stage kidney disease education, followed by text messages (over 12 weeks)

Other: Attention Control

Interventions

Fight Fatigue BEHAVIORAL

Combined progressive muscle relaxation and walking (increasing step count) 12-week intervention that consists of education/training followed by text messages.

Fight Fatigue

Attention Control OTHER

End-stage kidney disease education

Attention Control

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosis of ESKD diagnosis and receiving hemodialysis for at least 3 months
• Can read and speak English
• Fatigue measured via visual analogue scale, score ≥4 over the last week
• Able to stand and walk one block
• Has a cell phone that can receive text messages

You may not qualify if:

• Patient's nephrologist refuses for them to participate
• Unstable angina
• Unstable pulmonary disease or pulmonary symptoms that preclude participation
• Lower-extremity amputation without prosthetic (BKA, AKA) -Orthopedic or neurologic condition that would preclude walking or tensing/releasing of muscles-
• Cognitive impairment that, in the judgement of the research team, precludes trial participation
• Participation in the formative phase of the development of Fight Fatigue

Sponsors & Collaborators

• University of Illinois at Chicago: lead
• National Center for Complementary and Integrative Health (NCCIH): collaborator

Study Sites (1)

UI Health/University of Illinois Chicago

Chicago, Illinois, 60612, United States

RECRUITING

MeSH Terms

Conditions

Fatigue

Condition Hierarchy (Ancestors)

Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Mary Hannan, PhD

CONTACT

3123554838; mhanna22@uic.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: May 23, 2025
• First Posted: June 10, 2025
• Study Start: September 2, 2025
• Primary Completion (Estimated): February 1, 2027
• Study Completion (Estimated): June 1, 2027
• Last Updated: September 26, 2025

Record last verified: 2025-06

Locations

US (1)