Thoracic Mobilization for Restrictive Lung Disease

NCT07012733 | Not Yet Recruiting

• 1 other identifier: CNUSH2025-04-001
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate the immediate effects of thoracic mobilization techniques on cough capacity, dyspnea, and pulmonary function in patients with restrictive lung disease. The intervention will be applied in a single session, and outcomes will be measured before and after the intervention to evaluate short-term physiological changes.

Conditions

Restrictive Lung Disease

Keywords

thoracic mobilization; pulmonary function; cough capacity; dyspnea; restrictive pulmonary disorder

Outcome Measures

Primary Outcomes (1)

• Pulmonary function test

  Pulmonary function will be assessed using a standard spirometry test, including FVC and FEV1. The test will be conducted by a trained technician according to ATS/ERS guidelines to evaluate respiratory function.

  Immediately before and immediately after intervention on Day 1

Secondary Outcomes (2)

• Cough peak flow

  Immediately before and immediately after intervention on Day 1

• Dyspnea

  Immediately before and immediately after intervention on Day 1

Study Arms (2)

Thoracic mobilization group

EXPERIMENTAL

Participants receive thoracic mobilization techniques

Other: Thoracic mobilization; Other: conventional therapy

conventional therapy group

ACTIVE COMPARATOR

Participants receive conventional respiratory therapy

Other: conventional therapy

Interventions

Thoracic mobilization OTHER

Participants in this group will receive thoracic mobilization techniques in addition to conventional respiratory therapy. Thoracic mobilization will be delivered by a licensed physical therapist using passive manual techniques targeting the thoracic spine and rib cage to improve chest wall mobility and respiratory function.

Thoracic mobilization group

conventional therapy OTHER

Participants in this group will receive conventional respiratory therapy, including diaphragmatic breathing, pursed-lip breathing, and chest expansion exercises. The therapy will be administered by a licensed physical therapist following standard pulmonary rehabilitation protocols.

Thoracic mobilization group; conventional therapy group

Eligibility Criteria

• Age: 19 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 19 years or older
• Currently receiving respiratory therapy at C Hospital in Sejong City
• Pulmonary function test indicating restrictive pattern: FVC \< 80% and FEV1/FVC ≥ 70%
• FVC above the lower limit of normal (LLN) for age and sex
• Diagnosed with restrictive lung disease, such as idiopathic pulmonary fibrosis, scoliosis, or neuromuscular disorders (e.g., myopathy, amyotrophic lateral sclerosis)

You may not qualify if:

• FEV1/FVC ratio \< 70%
• Evidence of airway obstruction on pulmonary function testing

Sponsors & Collaborators

• Chungnam National University Sejong Hospital: lead

Study Sites (1)

Chungnam National University Sejong Hospital

Sejong, 30099, South Korea

Location

Related Publications (1)

• Kelzuyuki, T., Noriko, S. The immediate effect of chest mobilization tech. in patients of COPD. The Journal of Japanese Physical Therapy Association.(JPTA). 2007;34(2): 20070420.

  BACKGROUND

MeSH Terms

Conditions

Dyspnea

Condition Hierarchy (Ancestors)

Respiration Disorders; Respiratory Tract Diseases; Signs and Symptoms, Respiratory; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Jungwoo Shim, PT, PhD Candidate

CONTACT

+82 10-2509-6107; sjw0812@naver.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Masking Details: Outcome assessors will be blinded to group assignment to minimize detection bias during post-intervention evaluations
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: This is a randomized, parallel-group clinical trial comparing thoracic mobilization techniques to conventional respiratory therapy in patients with restrictive lung disease.

Study Record Dates

• First Submitted: May 22, 2025
• First Posted: June 10, 2025
• Study Start: June 9, 2025
• Primary Completion: November 18, 2025
• Study Completion: December 26, 2025
• Last Updated: June 10, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP
• Time Frame: IPD and supporting documents will be available beginning 6 months after publication of the primary results and will be accessible for up to 2 years.
• Access Criteria: De-identified individual participant data and supporting documents will be available to qualified researchers for academic purposes. Requests must include a methodologically sound proposal and will be subject to approval by the study team. Data will be shared through secure institutional data transfer.

Locations

KR (1)