SNU IBD Cohort Study : Searching for Characterization of High Risk Populations for Developing Inflammatory Bowel Disease

NCT07011979 | Recruiting

• 1 other identifier: H-2110-155-1266
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to investigate characteristics of individuals at high risk for developing Inflammatory Bowel Disease (IBD) in order to identify risk factors associated with its incidence. The main question it aims to answer is: What are the risk factors for developing Inflammatory Bowel Disease? Researchers will compare groups at high risk for IBD to healthy populations and to patients already diagnosed with IBD. Participants will

• undergo assessments of general demographic and clinical characteristics.
• be monitored for symptoms using questionnaires administered at regular intervals.
• have blood tests and stool examinations performed. In cases where participants undergo colonoscopy for routine clinical indications, gut biopsies will also be performed.

Conditions

Inflammatory Bowel Disease (IBD)

Keywords

Crohn Disease; Ulcerative Colitis; Psoriasis; Ankylosing Spondylitis

Outcome Measures

Primary Outcomes (1)

• Incidence of Inflammatory Bowel Disease

  Up to 20 years from enrollment

Eligibility Criteria

• Age: 10 Years+
• Sex: all
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of individuals at high risk for Inflammatory Bowel Disease (IBD), including: (1) first-degree relatives of IBD patients who routinely visit the outpatient clinics; (2) individuals with a confirmed positive serum ASCA result identified in the outpatient clinics; and (3) patients with autoimmune diseases who are regularly followed at outpatient clinics. Participants will be recruited from Seoul National University Hospital, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, and Seoul National University Hospital Healthcare System Gangnam Center.

You may qualify if:

• first-degree relatives of Inflammatory Bowel Disease patients
• patients who are diagnosed with autoimmune diseases
• patients with functional gastrointestinal disorders who are ASCA-positive

You may not qualify if:

• Patients with symptoms such as a 10% weight loss within 3 months, abdominal pain, hematochezia, or diarrhea will undergo colonoscopy, and those diagnosed with Inflammatory Bowel Disease will be excluded.
• Treatment history of Diabetes Mellitus, Irritable Bowel Syndrome, or colon cancer.

Sponsors & Collaborators

• Seoul National University Hospital: lead

Study Sites (1)

Seoul National University Hospital

Seoul, South Korea

RECRUITING

MeSH Terms

Conditions

Inflammatory Bowel Diseases; Crohn Disease; Colitis, Ulcerative; Psoriasis; Spondylitis, Ankylosing

Condition Hierarchy (Ancestors)

Gastroenteritis; Gastrointestinal Diseases; Digestive System Diseases; Intestinal Diseases; Colitis; Colonic Diseases; Skin Diseases, Papulosquamous; Skin Diseases; Skin and Connective Tissue Diseases; Axial Spondyloarthritis; Spondylarthropathies; Spondylarthritis; Spondylitis; Spinal Diseases; Bone Diseases; Musculoskeletal Diseases; Ankylosis; Joint Diseases; Arthritis

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 5 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: June 2, 2025
• First Posted: June 10, 2025
• Study Start: January 7, 2022
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: June 10, 2025

Record last verified: 2025-04

Locations

KR (1)