Testicular Sperm Retrieval Rate After Varicocele Ligation in Men With Non Obstructive Azoospermia

NCT07008495 | Recruiting DMC

• 1 other identifier: Non-Obstructive Azoospermia
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

A varicocele is an abnormal dilatation and tortuosity of the veins of the spermatic cord. Although varicoceles are common in the general population and are frequently found on routine physical examinations, they represent the most common correctable cause of male factor infertility. Male factor infertility affects up to half of all couples struggling to conceive, and 10-20% of men evaluated for infertility are found to be azoospermic.

Conditions

Non-obstructive Azoospermia

Outcome Measures

Primary Outcomes (1)

• Sperm retrieval rate

  Evaluation of Sperm retrieval rate after varicocelectomy in men with non obstructive azoospermia

  Two Weeks

Secondary Outcomes (1)

• fertility rate

  3 months from the operation

Study Arms (2)

Group of varicocele ligation

ACTIVE COMPARATOR

About 25 male patients will undergo varicocele ligation then microTESE.

Procedure: varicocelectomy

Group of TESE

ACTIVE COMPARATOR

About 25 male patients will undergo microTESE without varicocele ligation.

Procedure: varicocelectomy

Interventions

varicocelectomy PROCEDURE

to detect testicular sperm retrieval rate after varicocelectomy in men with non obstructive azoospermia.

Also known as: TESE

Group of TESE; Group of varicocele ligation

Eligibility Criteria

• Age: 20 Years - 60 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Men with non obstructive azoospermia.
• Clinically palpable varicocele ( unilateral or bilateral ).

You may not qualify if:

• Known cases of obstructive azoospermia.
• Non palpable varicocele.
• Uncorrectable female causes of infertility.
• genetic abnormalities like klinefelter syndrome.

Sponsors & Collaborators

• South Valley University: lead

Study Sites (1)

South Valley University Hospital

Qina, South Valley, Egypt

RECRUITING

Study Officials

• Gamal A. Alsagheer, Professor

  Urology Department, Faculty of Medicine, South Valley University, Qena, Egypt

  STUDY CHAIR

Central Study Contacts

Yacoub Nagah Abdelwahab, Resident

CONTACT

+201092142396; dryacoubn99@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident at Urology Department, Faculty of Medicine

Study Record Dates

• First Submitted: May 28, 2025
• First Posted: June 6, 2025
• Study Start: September 1, 2024
• Primary Completion: August 20, 2025
• Study Completion: August 31, 2025
• Last Updated: June 13, 2025

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL

Locations

EG (1)