NCT07008326

Brief Summary

The increasing prevalence of overweight and obesity is becoming a concern worldwide as it is associated with the increased prevalence of non-communicable diseases. One of the main reasons for this problem is that more adults did not fulfill the weekly physical activity recommendations, with the lack of time and motivation as the main factor. This study aims to compare the effectiveness of a high-intensity circuit training program and the more familiar moderate-intensity continuous training in improving body composition, cardiorespiratory fitness, lipid profile, oxidative stress, and inflammatory markers in young adult males. At the same time, it also explores its adherence through its enjoyment scale and gradual changes in supervision. This experimental study compares pre- and post-tests in the two groups. 3-days food records and 7-days physical activity will be measured monthly as the confounding factors.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
36

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Jun 2025

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 25, 2025

Completed
1 month until next milestone

Study Start

First participant enrolled

June 1, 2025

Completed
5 days until next milestone

First Posted

Study publicly available on registry

June 6, 2025

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 30, 2025

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

September 30, 2025

Completed
Last Updated

June 6, 2025

Status Verified

June 1, 2025

Enrollment Period

3 months

First QC Date

April 25, 2025

Last Update Submit

June 4, 2025

Conditions

Keywords

high intensity circuit trainingmoderate intensity continuous trainingoverweightyoung adult male

Outcome Measures

Primary Outcomes (14)

  • Body Mass Index

    Weight and Height will be combined to report Body Mass Index in kg/m\^2

    Week 0, 4, 8, 12

  • Body Fat Percentage

    The total percentage of body fat mass measured by BIA Tanita MC-780 in %

    Week 0, 4, 8, 12

  • Muscle Mass

    Muscle mass measured by BIA Tanita MC-780 in kilograms

    Week 0, 4, 8, 12

  • Visceral Fat Mass

    Visceral fat mass measured by BIA Tanita MC-780 in kilograms

    Week 0, 4, 8, 12

  • Waist Circumference

    Waist circumference measured in centimeters

    Week 0, 4, 8, 12

  • Cardiorespiratory Fitness

    VO2Max or VO2peak depends on the feasibility. The cardiac output (mL/min) and body weight (kg) will be combined in mL/kg. min

    Week 0, 12

  • Total Cholesterol

    Total cholesterol in blood measured in mg/dL

    Week 0, 12

  • High-Density Lipoprotein (HDL)

    HDL concentration in blood measured in mg/dL

    Week 0, 12

  • Low-Density Lipoprotein (LDL)

    LDL concentration in blood measured in mg/dL

    Week 0, 12

  • Triglyceride

    Triglyceride concentration in blood measured in mg/dL

    Week 0, 12

  • Superoxide dismutase

    Superoxide dismutase concentration in blood from whole blood sample measured in U/mL

    Week 0, 12

  • Malondialdehyde

    Malondialdehyde concentration in blood from whole blood samples measured in micromolar

    Week 0, 12

  • Tumor Necrosis Factor-alpha

    Tumor Necrosis Factor-alpha concentration in blood measured in pg/mL

    Week 0, 12

  • Interleukin-6

    Interleukin-6 concentration in blood measured in pg/mL

    Week 0, 12

Secondary Outcomes (1)

  • Enjoyment

    Up to 12 weeks

Study Arms (2)

High Intensity Circuit Training

EXPERIMENTAL

High Intensity Circuit Training, a bodyweight exercise program performed 3 times per week with increased intensity every 4 weeks

Behavioral: High Intensity Circuit Training

Moderate Intensity Continuous Training

ACTIVE COMPARATOR

Moderate Intensity Continuous Training, brisk walk or jogging based exercise with increased intensity every 2-4 weeks

Behavioral: Moderate Intensity Continuous Training

Interventions

HICT: 3x/week high intensity circuit training for 12 weeks

High Intensity Circuit Training

3x/week moderate intensity continuous training for 12 weeks

Moderate Intensity Continuous Training

Eligibility Criteria

Age18 Years - 30 Years
Sexmale
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Overweight (BMI 23-24.9 kg/m2)
  • Physically inactive in the last 6 months before the study (\<150 minutes of moderate-intensity activity and \<75 minutes of high-intensity activity)
  • Willing to participate in exercise program for 12 weeks
  • No other exercise program during the study period

You may not qualify if:

  • Smoking
  • Medical comorbidities (diabetes mellitus, hypertension, cardiovascular disease, asthma, dyslipidaemia, epilepsy)
  • History of musculoskeletal injuries or health problems related to exercise in the last 1 year
  • Dropout Criteria
  • Resigning
  • Not participating in the endline assessment
  • Not participating in the exercise program for 2 consecutive weeks
  • Experiencing injury or health problems that led to the inability to participate in the program for 2 consecutive weeks

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Universitas Indonesia

Jakarta Pusat, DKI Jakarta, 10430, Indonesia

Location

Related Publications (1)

  • Klika B, Jordan C. High-intensity circuit training using body weight: maximum results with minimal investment. ACSM's Health & Fitness Journal. June 2013; 17(3):p 8-13.

    BACKGROUND

MeSH Terms

Conditions

Overweight

Condition Hierarchy (Ancestors)

OvernutritionNutrition DisordersNutritional and Metabolic DiseasesBody WeightSigns and SymptomsPathological Conditions, Signs and Symptoms

Study Officials

  • Nani C Sudarsono, Doctor

    Fakultas Kedokteran Universitas Indonesia

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Nani C Sudarsono, Doctor

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Dr. dr. Nani Cahyani Sudarsono, Sp.KO

Study Record Dates

First Submitted

April 25, 2025

First Posted

June 6, 2025

Study Start

June 1, 2025

Primary Completion

August 30, 2025

Study Completion

September 30, 2025

Last Updated

June 6, 2025

Record last verified: 2025-06

Locations