Real-world Study on Liver Cancer Risk in Chronic Hepatitis B Patients With Family History of Liver Cancer
A Real-World Study on Reducing the Risk of Liver Cancer in Chronic Hepatitis B Patients With a Family History of HBV-Related Liver Cancer.
1 other identifier
observational
1,500
1 country
555
Brief Summary
This study is a prospective, multicenter, real-world cohort study designed to compare the long-term outcomes of chronic hepatitis B patients with a family history of HBV-related hepatocellular carcinoma (HCC) who receive PEG IFNα-2b combined with nucleos(t)ide analogues or nucleos(t)ide monotherapy. The primary endpoint is the incidence rate of HCC, and secondary endpoints include the rate of HBsAg seroclearance, changes in liver fibrosis, and survival rates. The study will last for 5 years and enroll approximately 15,000 patients, aiming to provide evidence-based optimization for CHB treatment regimens.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jun 2025
Longer than P75 for all trials
555 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 28, 2025
CompletedStudy Start
First participant enrolled
June 1, 2025
CompletedFirst Posted
Study publicly available on registry
June 5, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2032
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 1, 2032
June 5, 2025
May 1, 2025
6.6 years
May 28, 2025
May 28, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
5-year incidence of hepatocellular carcinoma (HCC)
From the start of antiviral treatment to 5 years of follow-up.
Secondary Outcomes (10)
HBsAg seroclearance rate
From the start of antiviral treatment to 5 years of follow-up.
HBeAg seroclearance rate
From the start of antiviral treatment to 5 years of follow-up.
HBV DNA level
From the start of antiviral treatment to 5 years of follow-up.
HBsAg level
From the start of antiviral treatment to 5 years of follow-up.
HBeAg level
From the start of antiviral treatment to 5 years of follow-up.
- +5 more secondary outcomes
Study Arms (2)
PEG IFNα-2b Group
Nucleos(t)ide Monotherapy Group
Interventions
The study will not involve any additional interventions, nor will it interfere with any related clinical decision-making.
The study will not involve any additional interventions, nor will it interfere with any related clinical decision-making.
Eligibility Criteria
Patients who meet the inclusion criteria but do not meet the exclusion criteria were screened from multiple centers nationwide.
You may qualify if:
- (1) Chronic hepatitis B (CHB) patients with HBsAg positivity for over 6 months; (2) Family history of HBV-related hepatocellular carcinoma (HCC) (first- or second-degree relatives with HBV-related HCC); (3) Age ≥ 30 years, regardless of gender; (4) Based on real-world clinical practice, patients receiving nucleos(t)ide analogue (NA) therapy, such as Entecavir (ETV), Tenofovir Disoproxil Fumarate (TDF), Tenofovir Alafenamide Fumarate (TAF), or Tenofovir Amibufenamide (TMF), or those receiving combination therapy with nucleos(t)ide analogues and PEG IFNα-2b; (5) Negative pregnancy test within 24 hours before the first dose (for women of childbearing potential); (6) Voluntary participation, with the ability to understand and sign the informed consent form.
You may not qualify if:
- (1) Patients diagnosed with hepatocellular carcinoma (HCC) or malignancies in other organ systems prior to treatment; (2) Patients with contraindications to Peg IFN α-2b (refer to the Guidelines for the Prevention and Treatment of Chronic Hepatitis B (2022 Edition) for details); (3) Patients in the immune-tolerant phase of HBV infection; (4) Patients scheduled for or with a history of organ transplantation; (5) Patients with hypersensitivity to interferon or any contraindication listed in the drug's prescribing information; (6) Other conditions deemed unsuitable for enrollment by the investigator.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (555)
Qitaihe Infectious Disease Hospital
Heilongjiang, Heilongjiang, China
Yizheng People's Hospital
Yizheng, Jiangsu, China
Changle County People's Hospital
Changle, Shandong, China
Juxian People's Hospital
Junxian, Shandong, China
Pingdu People's Hospital, Shandong
Pingdu, Shandong, China
Zouping People's Hospital
Zouping, Shandong, China
Huozhou Coal & Electricity Group General Hospital Co., Ltd.
Huozhou, Shanxi, China
Huozhou People's Hospital, Huozhou Medical Group
Huozhou, Shanxi, China
Huozhou People's Hospital
Huozhou, Shanxi, China
Fenxi Mining Group Employees General Hospital
Jiexiu, Shanxi, China
Jiexiu Medical Group People's Hospital
Jiexiu, Shanxi, China
Anfu County People's Hospital
Anfu, China
Ankang Central Hospital
Ankang, China
Ankang Hospital of Traditional Chinese Medicine
Ankang, China
Anning Hospital of Traditional Chinese Medicine
Anning, China
Anqing First People's Hospital
Anqing, China
Anqing Municipal Hospital
Anqing, China
Anshan Infectious Disease Hospital
Anshan, China
Anyue County People's Hospital
Anyue, China
Affiliated Hospital of Youjiang Medical University for Nationalities
Baise City, China
Baoding First Central Hospital
Baoding, China
Baoding People's Hospital
Baoding, China
Baotou Central Hospital
Baotou, China
China National Medicines (CNM) Northern Hospital
Baotou, China
The Third Staff Hospital of Baotou Steel Group
Baotou, China
Beihai People's Hospital
Beihai, China
Beijing Daxing District People's Hospital
Beijing, China
Beijing Ditan Hospital, Capital Medical University
Beijing, China
Beijing Ditan Hospital
Beijing, China
Beijing Fangshan District First Hospital
Beijing, China
Beijing Hospital of Traditional Chinese Medicine, Capital Medical University
Beijing, China
Beijing Huaxin Hospital
Beijing, China
Beijing Liangxiang Hospital, Fangshan District
Beijing, China
Beijing Tsinghua Changgung Hospital
Beijing, China
Beijing You'an Hospital, Capital Medical University
Beijing, China
Beijing You'an Hospital
Beijing, China
Dongfang Hospital, Beijing University of Chinese Medicine
Beijing, China
Dongzhimen Hospital, Beijing University of Chinese Medicine
Beijing, China
Peking University People's Hospital
Beijing, China
Peking University Third Hospital
Beijing, China
Shunyi Hospital of Traditional Chinese Medicine, Beijing
Beijing, China
The Fifth Medical Center of PLA General Hospital
Beijing, China
Wangfu Hospital of Integrated Traditional Chinese and Western Medicine
Beijing, China
Xiyuan Hospital, China Academy of Chinese Medical Sciences
Beijing, China
Xuanwu Hospital, Capital Medical University
Beijing, China
Bengbu Fifth People's Hospital
Bengbu, China
Guzhen County Hospital of Traditional Chinese Medicine
Bengbu, China
Guzhen County People's Hospital
Bengbu, China
The First Affiliated Hospital of Bengbu Medical University
Bengbu, China
Benxi Sixth People's Hospital
Benxi, China
Beihai Tuberculosis Prevention and Treatment Hospital
Bihua, China
Binzhou Central Hospital
Binzhou, China
Binzhou People's Hospital
Binzhou, China
Bozhou Hospital of Traditional Chinese Medicine
Bozhou, China
Bozhou People's Hospital
Bozhou, China
Lixin County People's Hospital
Bozhou, China
Mengcheng First People's Hospital
Bozhou, China
Cangzhou Third Hospital
Cangzhou, China
The First Hospital of Jilin University
Changchun, China
Changji Branch of the First Affiliated Hospital of Xinjiang Medical University
Changji, China
Changji Hui Autonomous Prefecture People's Hospital
Changji, China
Changxing County People's Hospital
Changxing, China
Changzhi People's Hospital
Changzhi, China
Heping Hospital Affiliated to Changzhi Medical College
Changzhi, China
Changzhou Third People's Hospital
Changzhou, China
Yizheng People's Hospital
Changzhou, China
Chaoyang Fourth Hospital
Chaoyang, China
Kazuo County Central Hospital
Chaoyang, China
Chengdu Fifth People's Hospital
Chengdu, China
Chengdu Public Health Clinical Medical Center
Chengdu, China
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital
Chengdu, China
West China Hospital, Sichuan University
Chengdu, China
Chifeng Baoshan Hospital
Chifeng, China
Chifeng Songshan Traditional Chinese Medicine & Mongolian Medicine Hospital
Chifeng, China
Chifeng Tumor Hospital
Chifeng, China
Chizhou People's Hospital
Chizhou, China
Mingguang People's Hospital
Chuzhou, China
Dali Bai Autonomous Prefecture People's Hospital
Dali, China
The First Affiliated Hospital of Dalian Medical University
Dalian, China
Dandong Sixth People's Hospital
Dandong, China
Daqing Second Hospital
Daqing, China
China National Medicines & Health Products Datong Coal Mine Group General Hospital
Datong, China
Datong Fourth People's Hospital
Datong, China
Donggang Central Hospital
Donggang, China
Dongguan Eastern Central Hospital
Dongguan, China
Dongguan Ninth People's Hospital
Dongguan, China
Dongtai People's Hospital
Dongtai, China
Dongying Hospital of Traditional Chinese Medicine
Dongying, China
Dongying People's Hospital
Dongying, China
Shengli Oilfield Central Hospital
Dongying, China
Jianshi County People's Hospital
Enshi, China
Lichuan Traditional Chinese Medicine Hospital for Ethnic Minorities
Enshi, China
Ezhou Central Hospital
Ezhou, China
Fengcheng People's Hospital
Fengcheng, China
Fenyang Hospital
Fenyang, China
Foshan Hospital of Traditional Chinese Medicine
Foshan, China
Sanshui Hospital of Zhujiang Hospital, Southern Medical University
Foshan, China
Shunde Hospital Affiliated to Jinan University
Foshan, China
The Eighth Affiliated Hospital of Southern Medical University
Foshan, China
The Fourth People's Hospital of Foshan
Foshan, China
Fuxin Infectious Disease Hospital
Fuxin, China
Fuyang Fifth People's Hospital
Fuyang, China
Fuyang Hospital Affiliated to Anhui Medical University
Fuyang, China
Fuyang People's Hospital
Fuyang, China
Fuyang Second People's Hospital
Fuyang, China
Linquan County People's Hospital
Fuyang, China
Taihe County Hospital of Traditional Chinese Medicine
Fuyang, China
Jinxi County People's Hospital
Fuzhou, China
Lichuan County People's Hospital
Fuzhou, China
Linchuan District First People's Hospital
Fuzhou, China
Nanfeng County People's Hospital
Fuzhou, China
The First Affiliated Hospital of Fujian Medical University
Fuzhou, China
Dingnan County First People's Hospital
Ganzhou, China
Ganzhou Fifth People's Hospital
Ganzhou, China
Ganzhou People's Hospital
Ganzhou, China
Yudu County People's Hospital
Ganzhou, China
Gaomi People's Hospital
Gaomi, China
Guangzhou Eighth People's Hospital, Guangzhou Medical University
Guangzhou, China
Guangzhou First People's Hospital
Guangzhou, China
Guangzhou Medical University Affiliated Panyu Central Hospital
Guangzhou, China
Huadu District People's Hospital, Guangzhou
Guangzhou, China
Nansha District People's Hospital, Guangzhou
Guangzhou, China
Panyu District Maternal and Child Health Hospital, Guangzhou
Guangzhou, China
Shijing People's Hospital, Baiyun District, Guangzhou
Guangzhou, China
The Fourth Affiliated Hospital of Guangzhou Medical University
Guangzhou, China
The Third Affiliated Hospital of Guangzhou Medical University
Guangzhou, China
The Third Affiliated Hospital of Southern Medical University
Guangzhou, China
Guilin Hospital of Traditional Chinese Medicine
Guilin, China
The Third People's Hospital of Guilin
Guilin, China
Xing'an County People's Hospital
Guilin, China
Hainan Provincial People's Hospital
Haikou, China
Hailin People's Hospital
Hailin, China
Hami Central Hospital
Hami, China
Xinjiang Production and Construction Corps 13th Division Hongxing Hospital
Hami, China
Handan Central Hospital
Handan, China
Handan First Hospital
Handan, China
Handan Fourth Hospital
Handan, China
Handan Infectious Disease Hospital
Handan, China
Linzhang County People's Hospital
Handan, China
Wei County People's Hospital
Handan, China
Yongnian District First People's Hospital
Handan, China
Hangzhou Xixi Hospital
Hangzhou, China
Lin'an District First People's Hospital
Hangzhou, China
Linping District Hospital of Traditional Chinese Medicine
Hangzhou, China
The Second Affiliated Hospital of Zhejiang Chinese Medical University
Hangzhou, China
Chenggu County People's Hospital
Hanzhong, China
Hanbin District First Hospital
Hanzhong, China
Hanzhong Second People's Hospital
Hanzhong, China
Yang County People's Hospital
Hanzhong, China
Acheng District People's Hospital of Harbin
Harbin, China
Harbin First Hospital
Harbin, China
Harbin Sixth Hospital
Harbin, China
Heilongjiang Provincial Hospital
Harbin, China
The First Affiliated Hospital of Harbin Medical University
Harbin, China
The Fourth Affiliated Hospital of Harbin Medical University
Harbin, China
The Second Affiliated Hospital of Harbin Medical University
Harbin, China
Gu'an County Hospital of Traditional Chinese Medicine
Hebei, China
Anhui Provincial Hospital
Hefei, China
Hefei First People's Hospital Binhu Branch
Hefei, China
Hefei First People's Hospital
Hefei, China
Hefei Second People's Hospital
Hefei, China
Hefei Third People's Hospital
Hefei, China
The First Affiliated Hospital of Anhui Medical University
Hefei, China
Hegang Infectious Disease Hospital
Hegang, China
Hegang Mining General Hospital
Hegang, China
Beian First People's Hospital
Heihe, China
Heihe First People's Hospital
Heihe, China
Hengshui Third People's Hospital
Hengshui, China
Hotan Prefecture Specialized Hospital for Infectious Diseases
Hetian, China
Heze Municipal Hospital
Heze, China
Hezhou People's Hospital
Hezhou, China
Affiliated Hospital of Inner Mongolia Medical University
Hohhot, China
Hohhot Second Hospital
Hohhot, China
Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine
Hohhot, China
The 969th Hospital of the Joint Logistics Support Force
Hohhot, China
The Fourth Hospital of Inner Mongolia Autonomous Region
Hohhot, China
Hongze District People's Hospital
Huai'an, China
Huai'an Fifth People's Hospital
Huai'an, China
Huai'an Fourth People's Hospital
Huai'an, China
Huai'an No. 82 Hospital
Huai'an, China
Huainan First People's Hospital
Huainan, China
Huangshan Huangshan People's Hospital
Huangshan City, China
Huangshan People's Hospital
Huangshan City, China
Qimen County People's Hospital
Huangshan City, China
Xiuning County People's Hospital
Huangshan City, China
Daye People's Hospital
Huangshi, China
Huangshi Central Hospital
Huangshi, China
Huangshi Hospital of Traditional Chinese Medicine
Huangshi, China
Yangxin County People's Hospital
Huangshi, China
Huazhong University of Science and Technology
Hubei, China
Jiamusi Infectious Disease Hospital
Jiamusi, China
Jiangmen Central Hospital
Jiangmen, China
Xinhui People's Hospital
Jiangmen, China
Jianping County Hospital
Jianping, China
Tongji University Affiliated Oriental Hospital Jiaozhou
Jiaozhou, China
Affiliated Hospital of Beihua University
Jilin, China
Jilin City Infectious Disease Hospital
Jilin, China
Jilin Provincial Hepatobiliary Hospital
Jilin, China
Qingdao Jimo District People's Hospital
Jimo, China
Jinan People's Hospital
Jinan, China
Jiyang District Hospital of Traditional Chinese Medicine
Jinan, China
Shandong Provincial Hospital Affiliated to Shandong First Medical University
Jinan, China
Shandong Provincial Public Health Clinical Center
Jinan, China
The First Affiliated Hospital of Shandong First Medical University
Jinan, China
The Second Hospital of Shandong University
Jinan, China
Gaoping People's Hospital
Jincheng, China
Jincheng People's Hospital
Jincheng, China
Jincheng Third People's Hospital
Jincheng, China
Zezhou County People's Hospital
Jincheng, China
Gong'an County People's Hospital
Jingzhou, China
Jingzhou Central Hospital
Jingzhou, China
The First People's Hospital of Jingzhou, Hubei
Jingzhou, China
Jinhua Municipal Central Hospital
Jinhua, China
Jining Public Health Medical Center
Jining, China
Jinxiang County People's Hospital
Jining, China
Jinxian County People's Hospital
Jinxian, China
Jinzhong First People's Hospital
Jinzhong, China
Shanxi Coking Coal Fenxi Mining Group Employees General Hospital
Jinzhong, China
Jinzhou Central Hospital
Jinzhou, China
Jinzhou Infectious Disease Hospital
Jinzhou, China
Jiujiang Hospital of Traditional Chinese Medicine
Jiujiang, China
Jiujiang Third People's Hospital
Jiujiang, China
Jixi Infectious Disease Hospital
Jixi, China
Ji'an Central People's Hospital
Ji’an, China
Karamay Central Hospital
Karamay, China
Yunnan Provincial People's Hospital
Kunming, China
Laixi People's Hospital
Laixi, China
Laizhou People's Hospital
Laizhou, China
Lanzhou Petrochemical General Hospital
Lanzhou, China
Lanzhou Second People's Hospital
Lanzhou, China
The Second Hospital of Lanzhou University
Lanzhou, China
Dongfang Hospital of Lianyungang
Lianyungang, China
Guanyun County Hospital of Traditional Chinese Medicine
Lianyungang, China
Guanyun County People's Hospital
Lianyungang, China
Lianyungang Dongfang Hospital
Lianyungang, China
Lianyungang First People's Hospital
Lianyungang, China
Houma People's Hospital
Linfen, China
Linfen Central Hospital
Linfen, China
Linfen Second People's Hospital
Linfen, China
Linfen Third People's Hospital
Linfen, China
Xiangfen County People's Hospital
Linfen, China
Yaodu District People's Hospital
Linfen, China
Linkou County People's Hospital
Linkou, China
Hezheng County People's Hospital
Linxia, China
Linyi Hospital of Traditional Chinese Medicine
Linyi, China
Linyi People's Hospital
Linyi, China
Lishui Central Hospital
Lishui, China
Liuzhou People's Hospital
Liuchow, China
Liuzhou Workers' Hospital
Liuchow, China
Longnan First People's Hospital
Longnan, China
Liancheng County Hospital
Longyan, China
Longyan People's Hospital
Longyan, China
Longyan Second Hospital
Longyan, China
Tingzhou Hospital of Changting County
Longyan, China
Wuping County Hospital
Longyan, China
Affiliated Hospital of West Anhui Health Vocational College
Lu'an, China
Huoqiu First People's Hospital
Lu'an, China
Huoqiu Second People's Hospital
Lu'an, China
Huoshan County Hospital
Lu'an, China
Jinzhai County Hospital of Traditional Chinese Medicine
Lu'an, China
Lu'an Fourth People's Hospital
Lu'an, China
Lu'an Hospital of Traditional Chinese Medicine
Lu'an, China
Lu'an People's Hospital
Lu'an, China
Lu'an Yeji District People's Hospital
Lu'an, China
Lvliang People's Hospital
Lüliang, China
Wenshui County People's Hospital
Lüliang, China
Macheng People's Hospital
Macheng, China
Huazhou People's Hospital
Maoming, China
Ma'anshan Fourth People's Hospital
Ma’anshan, China
The Second Affiliated Hospital of Wannan Medical College
Ma’anshan, China
Meishan People's Hospital
Meishan, China
Mudanjiang Kang'an Hospital
Mudanjiang, China
Mudanjiang Second People's Hospital
Mudanjiang, China
Jiangxi Provincial People's Hospital
Nanchang, China
Nanchang County People's Hospital
Nanchang, China
Nanchang Ninth Hospital
Nanchang, China
The First Affiliated Hospital of Nanchang University
Nanchang, China
The Second Affiliated Hospital of Nanchang University
Nanchang, China
Nanbu County People's Hospital
Nanchong, China
Nangong People's Hospital
Nangong, China
Jiangsu Provincial People's Hospital
Nanjing, China
Lishui District People's Hospital
Nanjing, China
Nanjing Drum Tower Hospital
Nanjing, China
Nanjing Hospital of Traditional Chinese Medicine
Nanjing, China
Nanjing Second Hospital
Nanjing, China
Nanjing Tianyinshan Hospital
Nanjing, China
Qinhuai Medical District of Eastern Theater General Hospital
Nanjing, China
The Fourth Affiliated Hospital of Nanjing Medical University
Nanjing, China
Zhongda Hospital
Nanjing, China
The First Affiliated Hospital of Guangxi Medical University
Nanning, China
The First Affiliated Hospital of Guangxi University of Chinese Medicine
Nanning, China
The Second Affiliated Hospital of Guangxi Medical University
Nanning, China
The Second People's Hospital of Nanning
Nanning, China
Jianyang First Hospital of Nanping
Nanping, China
Nanping First Hospital
Nanping, China
Zhenghe County Hospital
Nanping, China
Affiliated Hospital of Nantong University
Nantong, China
Haimen District People's Hospital
Nantong, China
Nantong Third People's Hospital
Nantong, China
Qidong Third People's Hospital
Nantong, China
Bairin Left Banner People's Hospital
Neimeng, China
Hulunbuir People's Hospital
Neimeng, China
Morin Dawa Daur Autonomous Banner People's Hospital
Neimeng, China
Beilun District Hospital of Traditional Chinese Medicine
Ningbo, China
Ningbo Second Hospital
Ningbo, China
Ningcheng County Central Hospital
Ningcheng, China
Ordos Second People's Hospital
Ordos, China
Panjin Third People's Hospital
Panjin, China
Affiliated Hospital of Gansu Medical College
Pingliang, China
Huating Second People's Hospital
Pingliang, China
Zhuanglang County People's Hospital
Pingliang, China
Pingxiang People's Hospital
Pingxiang, China
Pingyang County People's Hospital
Pingyang, China
Affiliated Hospital of Putian University
Putian, China
Putian First People's Hospital
Putian, China
Putian Hanjiang Hospital
Putian, China
Huangdao District People's Hospital
Qingdao, China
Qingdao Eighth People's Hospital
Qingdao, China
Qingdao Public Health Clinical Center
Qingdao, China
The Affiliated Hospital of Qingdao University
Qingdao, China
Lianzhou People's Hospital
Qingyuan, China
Qingyuan People's Hospital
Qingyuan, China
The Second People's Hospital of Northern Guangdong
Qingyuan, China
Yangshan County People's Hospital
Qingyuan, China
Yingde People's Hospital
Qingyuan, China
Qingzhou People's Hospital
Qingzhou, China
Weifang Yidu Central Hospital
Qingzhou, China
Qinhuangdao Third Hospital
Qinhuangdao, China
The First People's Hospital of Qinzhou
Qinzhou, China
The Second People's Hospital of Qinzhou
Qinzhou, China
Qiqihar Seventh Hospital
Qiqihar, China
Anxi County Hospital of Traditional Chinese Medicine
Quanzhou, China
Anxi County Hospital
Quanzhou, China
Dehua County Hospital of Traditional Chinese Medicine
Quanzhou, China
Huian County Hospital of Traditional Chinese Medicine
Quanzhou, China
Jinjiang Hospital
Quanzhou, China
Nan'an Haidu Hospital
Quanzhou, China
Quangang District Hospital, Quanzhou
Quanzhou, China
Quanzhou Hospital of Traditional Chinese Medicine
Quanzhou, China
Shishi Hospital
Quanzhou, China
The 910th Hospital of the Joint Logistics Support Force
Quanzhou, China
The Second Affiliated Hospital of Fujian Medical University
Quanzhou, China
Yongchun County Hospital
Quanzhou, China
Rizhao Central Hospital
Rizhao, China
Rizhao People's Hospital
Rizhao, China
Rui'an Second People's Hospital
Rui’an, China
Ninghua County General Hospital
Sanming, China
Sanming First People's Hospital
Sanming, China
Sanming Hospital of Integrated Traditional Chinese and Western Medicine
Sanming, China
Sanming Second People's Hospital
Sanming, China
Youxi County General Hospital, Sanming
Sanming, China
Youxi County Hospital of Traditional Chinese Medicine, Sanming
Sanming, China
Qilu Hospital of Shandong University
Shandong, China
Shucheng People's Hospital
Shangcheng, China
Minhang District Central Hospital of Shanghai
Shanghai, China
Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, China
Shanghai General Hospital
Shanghai, China
Shanghai Jiao Tong University School of Medicine
Shanghai, China
Shanghai Public Health Clinical Center
Shanghai, China
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
Shanghai, China
Tongji Hospital Affiliated to Tongji University
Shanghai, China
Shangli County People's Hospital
Shangli, China
Guangxin District People's Hospital
Shangrao, China
Shangrao Central Hospital
Shangrao, China
Shangrao People's Hospital
Shangrao, China
Shangrao Second People's Hospital
Shangrao, China
Wuyuan County People's Hospital
Shangrao, China
Shawan City People's Hospital
Shawan, China
Shengjing Hospital of China Medical University
Shenyang, China
The 242 Hospital Affiliated to Shenyang Medical College
Shenyang, China
The First Affiliated Hospital of China Medical University
Shenyang, China
Bao'an District People's Hospital, Shenzhen
Shenzhen, China
Bao'an District Traditional Chinese Medicine Hospital, Shenzhen
Shenzhen, China
Fuyong People's Hospital, Bao'an District, Shenzhen
Shenzhen, China
Longgang Central Hospital, Shenzhen
Shenzhen, China
Longgang District People's Hospital, Shenzhen
Shenzhen, China
Longhua District People's Hospital, Shenzhen
Shenzhen, China
Nanshan District People's Hospital, Shenzhen
Shenzhen, China
Peking University Shenzhen Hospital
Shenzhen, China
Shenzhen Fourth People's Hospital
Shenzhen, China
Shenzhen Hospital of Southern Medical University
Shenzhen, China
Shenzhen People's Hospital
Shenzhen, China
Shenzhen Third People's Hospital
Shenzhen, China
Songgang People's Hospital, Bao'an District, Shenzhen
Shenzhen, China
Southern Medical University Shenzhen Hospital
Shenzhen, China
The Eighth Affiliated Hospital of Sun Yat-sen University
Shenzhen, China
The Seventh Affiliated Hospital of Sun Yat-sen University
Shenzhen, China
Yantian District People's Hospital, Shenzhen
Shenzhen, China
The First Hospital of Hebei Medical University
Shijiazhuang, China
Sinopharm Dongfeng General Hospital
Shiyan, China
Shouguang People's Hospital
Shouguang, China
Qionglai Medical Center Hospital
Sichuan, China
Songyuan Jilin Oilfield Hospital
Songyuan, China
Nanjing Drum Tower Hospital Group
Suqian, China
Shuyang County Hospital of Traditional Chinese Medicine
Suqian, China
Sihong First People's Hospital
Suqian, China
Suqian First People's Hospital
Suqian, China
Suqian Hospital Affiliated to Nanjing Drum Tower Hospital Group
Suqian, China
Suqian Zhongwu Hospital
Suqian, China
he First Affiliated Hospital of Soochow University
Suzhou, China
Kunshan First People's Hospital
Suzhou, China
Kunshan Hospital of Traditional Chinese Medicine
Suzhou, China
Rudong County People's Hospital
Suzhou, China
Suzhou Fifth People's Hospital
Suzhou, China
Suzhou Hospital of Integrated Traditional Chinese and Western Medicine
Suzhou, China
Suzhou Municipal Hospital
Suzhou, China
Suzhou Ninth People's Hospital
Suzhou, China
Taicang First People's Hospital
Suzhou, China
The Fourth Affiliated Hospital of Soochow University
Suzhou, China
Xiaoxian People's Hospital
Suzhou, China
Zhangjiagang First People's Hospital
Suzhou, China
Taihe County People's Hospital
Taihe, China
Shanxi Bethune Hospital
Taiyuan, China
Shanxi Provincial Hospital of Traditional Chinese Medicine
Taiyuan, China
Shanxi Provincial People's Hospital
Taiyuan, China
Taiyuan Central Hospital
Taiyuan, China
Taiyuan Third People's Hospital
Taiyuan, China
The First Hospital of Shanxi Medical University
Taiyuan, China
Taixing People's Hospital
Taizhou, China
Taixing Second People's Hospital
Taizhou, China
Taizhou People's Hospital
Taizhou, China
Taizhou Second People's Hospital
Taizhou, China
Xinghua People's Hospital
Taizhou, China
Zhejiang Taizhou Hospital
Taizhou, China
Tai'an Central Hospital
Tai’an, China
Tangshan Seventh Hospital
Tangshan, China
Tengzhou Central People's Hospital
Tengzhou, China
Baodi District People's Hospital
Tianjin, China
Binhai New Area Dagang Hospital
Tianjin, China
Tianjin Binhai People's Hospital
Tianjin, China
Tianjin Fifth Central Hospital
Tianjin, China
Tianjin Port Hospital
Tianjin, China
Tianjin Second People's Hospital
Tianjin, China
Tianjin TEDA Hospital
Tianjin, China
Tianjin Third Central Hospital
Tianjin, China
Tongjiang People's Hospital
Tongjiang, China
Tongliao Sixth People's Hospital
Tongliao, China
Tongling People's Hospital
Tongling, China
The Fifth Affiliated Hospital of Xinjiang Medical University
Ürümqi, China
The First Affiliated Hospital of Xinjiang Medical University
Ürümqi, China
Xinjiang Uyghur Autonomous Region Traditional Chinese Medicine Hospital
Ürümqi, China
Weifang People's Hospital
Weifang, China
The 970th Hospital of the Joint Logistics Support Force, PLA
Weihai, China
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, China
The Second Affiliated Hospital of Wenzhou Medical University
Wenzhou, China
Wenzhou Sixth People's Hospital
Wenzhou, China
Wuhai Fifth People's Hospital
Wuhai, China
Changjiang Shipping General Hospital (Wuhan Brain Hospital)
Wuhan, China
Hubei Third People's Hospital (Hubei Zhongshan Hospital)
Wuhan, China
Jiangxia District First People's Hospital, Wuhan
Wuhan, China
The Fifth Hospital of Wuhan
Wuhan, China
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, China
Wuhan Hankou Hospital
Wuhan, China
Wuhan Jinyintan Hospital
Wuhan, China
Wuhan Seventh Hospital
Wuhan, China
Gansu Wuwei Cancer Hospita
Wuwei, China
Wuwei People's Hospital
Wuwei, China
Jiangyin People's Hospital
Wuxi, China
Jiangyin Traditional Chinese Medicine Hepatobiliary Hospital
Wuxi, China
Taihu Hospital
Wuxi, China
Wuxi Fifth People's Hospital
Wuxi, China
Wuxi No. 2 Hospital of Traditional Chinese Medicine
Wuxi, China
Wuxi No. 5 People's Hospital
Wuxi, China
Wuxi Second Hospital of Traditional Chinese Medicine
Wuxi, China
Yixing People's Hospital
Wuxi, China
The Third People's Hospital of Wuzhou
Wuzhou, China
Wu'an First People's Hospital
Wu’an, China
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, China
The Second Affiliated Hospital of Air Force Medical University
Xi'an, China
The Second Affiliated Hospital of Xi'an Jiaotong University
Xi'an, China
The 909th Hospital of the Joint Logistics Support Force
Xiamen, China
The First Affiliated Hospital of Xiamen University
Xiamen, China
Xiamen Hospital of Traditional Chinese Medicine
Xiamen, China
Zhongshan Hospital Xiamen, Fudan University
Xiamen, China
Xiaogan Central Hospital
Xiaogan, China
Yunmeng County People's Hospital
Xiaogan, China
Qinghe County People's Hospital
Xingtai, China
Xingtai Fifth Hospital
Xingtai, China
Xingtai Ninth Hospital
Xingtai, China
Xingtai People's Hospital
Xingtai, China
Datong Hui and Tu Autonomous County People's Hospital
Xining, China
Qinghai Fourth People's Hospital
Xining, China
Qinghai Provincial People's Hospital
Xining, China
Qinghai Red Cross Hospital
Xining, China
Ili Kazakh Autonomous Prefecture Kuitun Hospital
Xinjiang, China
Xinjiang Production and Construction Corps 6th Division Hospital
Xinjiang, China
Xintai People's Hospital
Xintai, China
Xiushui County First People's Hospital
Xiushui, China
People's Hospital of Tibet Autonomous Region
Xizang, China
Shannan People's Hospital
Xizang, China
Third People's Hospital of Tibet Autonomous Region
Xizang, China
Jixi County People's Hospital
Xuancheng, China
Xuancheng Central Hospital
Xuancheng, China
Xuancheng People's Hospital
Xuancheng, China
Affiliated Hospital of Xuzhou Medical University
Xuzhou, China
Feng County People's Hospital
Xuzhou, China
Pei County People's Hospital
Xuzhou, China
Pizhou People's Hospital
Xuzhou, China
Xuzhou Central Hospital
Xuzhou, China
Xuzhou Infectious Disease Hospital
Xuzhou, China
Xuzhou Mining Group Traditional Chinese Medicine Hospital
Xuzhou, China
Xuzhou New Health Hospital
Xuzhou, China
Yan'an Hospital of Traditional Chinese Medicine
Yanan, China
Yan'an People's Hospital
Yanan, China
Affiliated Hospital of Yanbian University
Yanbian, China
Dunhua City Hospital
Yanbian, China
Wangqing County People's Hospital
Yanbian, China
Funing County People's Hospital
Yancheng, China
Jianhu County People's Hospital
Yancheng, China
Xuyi County People's Hospital
Yancheng, China
Yancheng First People's Hospital
Yancheng, China
Yancheng Seventh People's Hospital
Yancheng, China
Yangquan Coal Mining Group General Hospital
Yangquan, China
Yangquan Third People's Hospital
Yangquan, China
Jiangdu District Third People's Hospital
Yangzhou, China
Northern Jiangsu People's Hospital
Yangzhou, China
Yangzhou Third People's Hospital
Yangzhou, China
Binzhou Medical University Yantai Affiliated Hospital
Yantai, China
Yantai Qishan Hospital
Yantai, China
Yibin First People's Hospital
Yibin, China
Dangyang People's Hospital
Yichang, China
Yichang Central People's Hospital
Yichang, China
Yichang Third People's Hospital
Yichang, China
Zhijiang People's Hospital
Yichang, China
Yichun People's Hospital
Yichun, China
Ningxia Medical University General Hospital
Yinchuan, China
Yingkou Third People's Hospital
Yingkou, China
Yingtan People's Hospital
Yingtan, China
Ili Kazakh Autonomous Prefecture Traditional Chinese Medicine
Yining, China
Yining City People's Hospital
Yining, China
Jingbian County People's Hospital
Yulin, China
The First People's Hospital of Yulin
Yulin, China
The Second People's Hospital of Yulin
Yulin, China
Yulin First Hospital
Yulin, China
Yulin Hospital of Traditional Chinese Medicine
Yulin, China
Jishan County People's Hospital
Yuncheng, China
Linyi County People's Hospital
Yuncheng, China
Xia County People's Hospital
Yuncheng, China
Yanhu District People's Hospital, Yuncheng City
Yuncheng, China
Yongji People's Hospital
Yuncheng, China
Yuncheng Hospital of Traditional Chinese Medicine
Yuncheng, China
Yuncheng Second Hospital
Yuncheng, China
Shandong Health Group Zaozhuang Central Hospital
Zaozhuang, China
Zhangjiakou Infectious Disease Hospital
Zhangjiakou, China
Affiliated Hospital of Guangdong Medical University
Zhanjiang, China
Jurong People's Hospital
Zhenjiang, China
Yangzhong Hospital of Traditional Chinese Medicine
Zhenjiang, China
Yangzhong People's Hospital
Zhenjiang, China
Zhenjiang Third People's Hospital
Zhenjiang, China
The Second People's Hospital of Zhongshan
Zhongshan, China
Zhongshan Hospital of Traditional Chinese Medicine
Zhongshan, China
Zibo City No.148 Hospital
Zibo, China
Zibo Hospital of Traditional Chinese Medicine
Zibo, China
Zibo Infectious Diseases Hospital
Zibo, China
Zigong First People's Hospital
Zigong, China
Biospecimen
Collect blood samples as needed for omics testing.
MeSH Terms
Interventions
Study Officials
- PRINCIPAL INVESTIGATOR
Guiqiang Wang, Ph.D
Peking University First Hospital
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Chief physician
Study Record Dates
First Submitted
May 28, 2025
First Posted
June 5, 2025
Study Start
June 1, 2025
Primary Completion (Estimated)
January 1, 2032
Study Completion (Estimated)
December 1, 2032
Last Updated
June 5, 2025
Record last verified: 2025-05