NCT07006701

Brief Summary

The purpose of this study is to examine the natural history and risk factors of osteoarthritis (OA) and to explore the relationship between metabolic factors and OA progression.

Trial Health

63
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
4,000

participants targeted

Target at P75+ for all trials

Timeline
106mo left

Started Jun 2025

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
not yet recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress10%
Jun 2025Dec 2034

First Submitted

Initial submission to the registry

May 20, 2025

Completed
14 days until next milestone

Study Start

First participant enrolled

June 3, 2025

Completed
2 days until next milestone

First Posted

Study publicly available on registry

June 5, 2025

Completed
9.6 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2034

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2034

Last Updated

June 5, 2025

Status Verified

May 1, 2025

Enrollment Period

9.6 years

First QC Date

May 20, 2025

Last Update Submit

May 27, 2025

Conditions

Osteoarthritis

Outcome Measures

Primary Outcomes (1)

  • Incidence of Osteoarthritis

    The occurrence of clinically diagnosed osteoarthritis based on imaging and clinical symptoms during the follow-up period.

    Annually for 10 years

Secondary Outcomes (13)

  • Change in Joint Pain Severity (WOMAC Pain Subscale)

    Annually for 10 years

  • Change in Physical Function (WOMAC Subscale)

    Annually for 10 years

  • Change in Physical Function (SF-36 Physical Function Domain)

    Annually for 10 years

  • Timed Up and Go Test (TUGT)

    Annually for 10 years

  • Five Times Sit-to-Stand Test (5TSTS)

    Annually for 10 years

  • +8 more secondary outcomes

Eligibility Criteria

Age50 Years+
Sexall
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

This study will include adults aged 50 years and above to investigate osteoarthritis risk factors and progression in a general population-based cohort.

You may qualify if:

  • Aged 50 years and above
  • Long-term resident of the study area
  • Willing to participate and provide informed consent

You may not qualify if:

  • Hearing, speech, or mental impairments preventing effective communication
  • Unable to complete scheduled follow-up visits
  • Pregnant or planning pregnancy during the study period
  • Any other condition deemed unsuitable for participation by the researchers

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Beijing Tsinghua Chang Gung Hospital

Beijing, Beijing Municipality, 102218, China

Location

MeSH Terms

Conditions

Osteoarthritis

Condition Hierarchy (Ancestors)

ArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic Diseases

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 20, 2025

First Posted

June 5, 2025

Study Start

June 3, 2025

Primary Completion (Estimated)

December 31, 2034

Study Completion (Estimated)

December 31, 2034

Last Updated

June 5, 2025

Record last verified: 2025-05

Locations

CN(1)