Cardiac Rehabilitation in Coronary Artery Bypass Graft Surgery

NCT07006441 | Completed

• 1 other identifier: auhucgun04
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This randomized controlled trial investigates the comparative effects of a combined preoperative and postoperative cardiac rehabilitation program versus a postoperative-only program on functional capacity, pulmonary function, peripheral muscle strength, pain, kinesiophobia, and quality of life in patients undergoing coronary artery bypass graft (CABG) surgery. The study aims to determine whether initiating rehabilitation prior to surgery improves short-term postoperative outcomes.

Conditions

Coronary Artery Bypass Graft Surgery; Coronary Artery Disease

Keywords

Coronary Artery Disease; Coronary Artery Bypass Graft Surgery; Preoperative Cardiac Rehabilitation; Postoperative Cardiac Rehabilitation

Outcome Measures

Primary Outcomes (8)

• Forced Vital Capacity (FVC)

  Forced Vital Capacity will be measured before six-minute walk test according to the guideline of ERS.

  2 weeks

• Forced Expiratory Volume in 1 second (FEV1)

  Forced Expiratory Volume in 1 second will be measured before six-minute walk test according to the guideline of ERS.

  2 weeks

• Peak Expiratory Flow (PEF)

  Peak Expiratory Flow will be measured before six-minute walk test according to the guideline of ERS.

  2 weeks

• Forced Expiratory Flow 25-75% (FEF25-75)

  Forced Expiratory Flow 25-75% will be measured before six-minute walk test according to the guideline of ERS.

  2 weeks

• 6-minute Walk Test

  The 6-minute Walk Test will be performed according to ATS guidelines. Walking distance, minute ventilation, respiratory rate, inspiratory capacity and breathing reserve will be recorded.

  2 weeks

• M. Quadriceps Muscle Strength

  The m. quadriceps muscle strength will be measured using the MicroFet 2 hand-held dynamometer (Hogan Health Industries, USA). The test will be repeated three times for the dominant side and the average value in kilograms (kg) will be recorded.

  2 weeks

• M. Biceps Muscle Strength

  The m. biceps muscle strength will be measured using the MicroFet 2 hand-held dynamometer (Hogan Health Industries, USA). The test will be repeated three times for the dominant side and the average value in kilograms (kg) will be recorded.

  2 weeks

• Cough Peak Flow

  Cough Peak Flow (CPF) will be measured using a peak expiratory flow meter. Participants will be instructed to take a maximal deep breath and then cough as forcefully as possible into the device; the highest value from three trials will be recorded in liters per minute (L/min). Measurements will be performed in a seated position, ensuring a tight mouth seal and consistent technique.

  2 weeks

Secondary Outcomes (3)

• Level of Pain

  2 weeks

• Level of Fear of Movement

  2 weeks

• Level of Quality of Life

  2 weeks

Study Arms (2)

Experimental Group

EXPERIMENTAL

Preoperative cardiac rehabilitation + postoperative cardiac rehabilitation (structured exercise, respiratory physiotherapy, and patient education)

Other: Preoperative Cardiac Rehabilitation; Other: Postoperative Cardiac Rehabilitation

Control Group

ACTIVE COMPARATOR

Postoperative cardiac rehabilitation (structured exercise, respiratory physiotherapy, and patient education)

Other: Postoperative Cardiac Rehabilitation

Interventions

Preoperative Cardiac Rehabilitation OTHER

Structured exercise program, respiratory physiotherapy, and patient education

Experimental Group

Postoperative Cardiac Rehabilitation OTHER

Structured exercise program, respiratory physiotherapy, and patient education

Control Group; Experimental Group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Having undergone coronary artery bypass graft surgery
• Ejection Fraction (EF) \> 40%
• Being between the ages of 18-65
• Being able to speak, read and understand in their own language
• Volunteering to participate in the study

You may not qualify if:

• Having an active or suspected infection
• Presence of an active tumour
• History of thrombophlebitis or pulmonary embolism within the last 3 months
• Having an orthopaedic, neurological or cardiovascular disease that may affect the assessments

Sponsors & Collaborators

• Atlas University: lead

Study Sites (1)

Istanbul Atlas University

Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Coronary Artery Disease

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Study Officials

• Hikmet Ucgun, PT, PhD

  Atlas University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Randomized, Parallel Assignment

Study Record Dates

• First Submitted: May 28, 2025
• First Posted: June 5, 2025
• Study Start: August 1, 2024
• Primary Completion: August 1, 2025
• Study Completion: August 1, 2025
• Last Updated: August 27, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)