Efficacy of Diaphragmatic Proprioceptive Neuromuscular Facilitation on Functional Capacity and Pulmonary Function in Heavy Twenties Smokers

NCT07003893 | Completed

• 1 other identifier: IRB # 23/3/2024-2025
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Although research on the health risks of e-cigarettes is still limited, there is increasing evidence of debilitating lung disease and general immune dysfunction from e-cigarettes, leading to various infections. Moreover, there are concerns that e-cigarettes can cause general impairment in life functions and more importantly lung function .Although exercise can help quit smoking and reduce relapses .However, exercise has many other fitness benefits when done regularly for the general population, as well as for smokers. Exercise has been shown to help with smoking cessation, which has been an important factor preventing many smokers, especially younger people, from quitting. Breathing exercises, especially diaphragm exercises improves lung function, lifestyle and health risk factors and thus the risk of developing many chronic diseases. Both aerobic interventions and exercise can reduce the incidence of many of the prevalent cancers initiated by smoking, such as lung cancer. This is important because lung cancer is the most common type of cancer worldwide, and cigarette smoking is responsible for up to 90% of lung cancer cases worldwide.

Conditions

Smoking Dependence; Smoking Among Youth

Outcome Measures

Primary Outcomes (5)

• FEV1/FVC ( % )

  The ratio of the forced expiratory volume in the first one second to the forced vital capacity of the lungs. That can reflect pulmonary function , using portable spirometer ( SP 80B,China)

  pre and post 4 weeks

• FEV1 ( liters )

  Forced expiratory volume in 1 second that can reflect pulmonary function , using portable spirometer ( SP 80B,China)

  Pre and post 4 weeks

• PEF ( liters / minute )

  Peak expiratory flow (PEF), a key indicator of lung function,using portable spirometer ( SP 80B,China)

  pre and post 4 weeks

• FVC ( liters )

  Forced vital capacity (FVC) is the total amount of air exhaled during the FEV test. Forced expiratory volume and forced vital capacity are lung function tests , using portable spirometer ( SP 80B , China )

  Pre and post 4 weeks

• Chest expansion ( centimeter )

  A simple, noninvasive pulmonary function test used to assess chest wall mobility and, to a lesser extent, lung function , using tape measurement.

  Pre and post 4 weeks

Secondary Outcomes (1)

• Functional capacity

  Pre and post 4 weeks

Study Arms (2)

Control group

ACTIVE COMPARATOR

perform exercises using aerobic exercises only

Other: Diaphragmatic Proprioceptive Neuromuscular Facilitation + Aerobic exercises

Experimental group

EXPERIMENTAL

perform diaphragmatic proprioceptive neuromuscular facilitation and aerobic exercise

Other: Diaphragmatic Proprioceptive Neuromuscular Facilitation + Aerobic exercises

Interventions

Diaphragmatic Proprioceptive Neuromuscular Facilitation + Aerobic exercises OTHER

Control group will perform aerobic exercises only Experimental group will perform diaphragmatic proprioceptive neuromuscular facilitation in addition to aerobic exercises

Control group; Experimental group

Eligibility Criteria

• Age: 20 Years - 29 Years
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Adults aged 20-29 years.
• Subjects who have been smoking for 1 to 3 years.
• Subjects who not receiving medical treatment for respiratory diseases.
• Subjects who have clean family medical history.

You may not qualify if:

• Subjects who smoke cigars other than filtered cigarettes or tobacco pipes.
• Subjects with respiratory proplems.
• Participation in another clinical trial within the last 30 days.
• Endocrine and metabolic disorders (eg, hypothyroidism, hypercalcemia, diabetes mellitus, diabetes insipidus).
• Neurologic and psychiatric disorders (who can not understand the research project ).

Sponsors & Collaborators

• Al-Zaytoonah University of Jordan: lead

Study Sites (1)

Mohamed Saied Zidan

Cairo, 11571, Egypt

Location

MeSH Terms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant prof dr

Study Record Dates

• First Submitted: May 23, 2025
• First Posted: June 4, 2025
• Study Start: July 5, 2025
• Primary Completion: November 1, 2025
• Study Completion: November 2, 2025
• Last Updated: November 19, 2025

Record last verified: 2025-11

Locations

EG (1)