Impact of Persistent Inflammation-Immunosuppression-Catabolism Syndrome (PICS) on the Respiratory Physiology in Patients With Prolonged Mechanical Ventilation

NCT07002710 | Recruiting

• 1 other identifier: 202407047RINE
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Past research on PICS has mainly focused on the predictability and prognosis of PICS occurrence in ICU patients. Still, there is currently insufficient research on the role of PICS in the care setting of patients who have stabilized and are transferred to respiratory care units such as Respiratory Care Centers (RCCs) for weaning attempts. To understand the impact of PICS on the respiratory physiology of patients undergoing weaning from prolonged mechanical ventilation, investigators propose a one-year research plan

Conditions

PICS

Keywords

PICS

Outcome Measures

Primary Outcomes (1)

• Impact of Persistent Inflammation-Immunosuppression-Catabolism Syndrome (PICS) on the Respiratory Physiology in Patients with Prolonged Mechanical Ventilation

  To understand whether weaning training strategies for PICS and non-PICS patients may have different considerations when patients undergo spontaneous breathing testing.

  January 1st,2025 to December 31st,2026

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Potential candidates for screening are adult patients transferred from RCC who are still on ventilators and will undergo screening assessment by researchers.

You may qualify if:

• Patients are still receiving ventilator support when transferred to the ward where the study is conducted.
• Use the respirator continuously for at least 10 days.
• Vital signs are stable: blood pressure systolic blood pressure is not lower than 70 mmHg; heartbeat is not lower than 50/min and not higher than 160/min; respiratory rate is not higher than 50/min.
• When using respirator support, the oxygen concentration should not exceed 60%.

You may not qualify if:

• ．At least one of the following conditions occurs: 1. Pregnancy. 2. The patient refuses to undergo weaning from the respirator training. 3. The patient has no ability to drive spontaneous breathing.

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

National Taiwan University Hospital

Taipei, Taiwan

RECRUITING

Central Study Contacts

Jih-Shuin Jerng, MD, PhD, Principal Investigator

CONTACT

+886-2-23123456; jsjerng@ntu.edu.tw

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 12 Weeks
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 26, 2024
• First Posted: June 3, 2025
• Study Start: March 18, 2025
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2026
• Last Updated: June 3, 2025

Record last verified: 2024-11

Locations

TW (1)