Interleukin-6 in Plaque Psoriasis and Its Possible Role in Disease Severity

NCT07001904 | Completed

• 1 other identifier: 36264MS308/9/23
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

This study aimed to evaluate serum IL-6 levels in plaque psoriasis patients and investigate their correlation with disease severity.

Conditions

Interleukin-6; Plaque Psoriasis; Disease Severity

Outcome Measures

Primary Outcomes (1)

• Disease severity

  Disease severity was assessed using the Psoriasis Area and Severity Index (PASI), categorizing patients into mild (PASI \<5), moderate (PASI 5-10), and severe (PASI \>10) groups.

  3 months post-procedure

Study Arms (2)

Patients group

Patients with plaque psoriasis.

Other: Enzyme-linked immunosorbent assay (ELISA)

Control group

Sex- and age-matched healthy control individuals.

Other: Enzyme-linked immunosorbent assay (ELISA)

Interventions

Enzyme-linked immunosorbent assay (ELISA) OTHER

The enzyme-linked immunosorbent assay (ELISA) was utilized in order to determine the levels of IL-6 in the serum

Control group; Patients group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This cross-sectional work had been performed on 30 individuals with plaque psoriasis and 20 sex- and age-matched healthy controls.

You may qualify if:

• Age above 18 years.
• Both sexes.
• Patients clinically diagnosed with plaque psoriasis.

You may not qualify if:

• Patients who had received any treatment for psoriasis in the last three months.
• Patients with other types of psoriasis.
• Those currently receiving systemic treatment.
• Individuals with other inflammatory diseases.
• Pregnant or lactating women.
• Those using contraceptive pills.
• Patients with metabolic conditions like diabetes mellitus or thyroid disorders.

Sponsors & Collaborators

• Tanta University: lead

Study Sites (1)

Tanta University

Tanta, El-Gharbia, 31527, Egypt

Location

MeSH Terms

Interventions

Enzyme-Linked Immunosorbent Assay

Intervention Hierarchy (Ancestors)

Immunoenzyme Techniques; Immunoassay; Immunologic Techniques; Investigative Techniques; Immunosorbent Techniques; Immunohistochemistry; Molecular Probe Techniques

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident of Anesthesiology, Surgical Intensive Care and Pain Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.

Study Record Dates

• First Submitted: May 24, 2025
• First Posted: June 3, 2025
• Study Start: November 1, 2023
• Primary Completion: October 31, 2024
• Study Completion: October 31, 2024
• Last Updated: June 3, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author.

Locations

EG (1)