Metabolically Healthy Obesity Increases the Risks of MASLD and Hyperuricemia

NCT07001865 | Enrolling By Invitation

• 2 other identifiers: 2025-073RS-01MR-33-25-026108
• Study Type: observational
• Target: 17,040
• Locations: 1 country
• Sites: 1

Brief Summary

Although metabolically healthy obesity (MHO) is often considered a relatively benign obesity, its association with the risk of metabolic dysfunction-associated steatotic liver disease (MASLD) and hyperuricemia remains unclear. This study examined the associations between MHO and other metabolic-obesity phenotypes with MASLD and hyperuricemia, and explored the mediating roles of metabolic indicators.This study included 11,712 and 13,846 participants from a health examination cohort at the First Affiliated Hospital of Ningbo University for MASLD and hyperuricemia analyses, respectively. Participants were classified into four metabolic-obesity phenotypes, with MHO defined as obesity without metabolic syndrome components. The outcomes were MASLD and hyperuricemia. Cox regression and mediation analyses were conducted to assess associations and mediating effects.

Conditions

Metabolic Dysfunction-Associated Steatotic Liver Disease; Metabolically Healthy Obesity; Hyperuricemia

Outcome Measures

Primary Outcomes (1)

• Incidence of MASLD and Hyperuricemia

  through study completion

  7 years

Study Arms (2)

MASLD cohort

participants with non-MASLD at baseline

Hyperuricemia

participants with non-Hyperuricemia at baseline

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This cohort study included participants who underwent comprehensive health examinations at the Physical Examination Center of the First Affiliated Hospital of Ningbo University between 2017 and 2024. A total of 18,261 individuals aged 18 years or older who completed abdominal ultrasound examinations were initially considered. After excluding underweight individuals (BMI \< 18.5 kg/m²; N = 1,138) and those with missing data on height, weight, or metabolic syndrome (MetS) components (N = 83), 17,040 participants remained eligible for further analysis.For the MASLD incidence analysis, individuals with a baseline diagnosis of MASLD or other liver diseases (N = 5,328) were excluded, resulting in 11,712 participants. For the hyperuricemia incidence analysis, those with baseline hyperuricemia (N = 3,194) were further excluded, yielding 13,846 eligible participants. During a median follow-up period of up to 7 years, 3,756 incident cases of MASLD and 3,294 incident cases of hyperuricemia were

You may qualify if:

• Underwent comprehensive health examinations at the Physical Examination Center of the First Affiliated Hospital of Ningbo University between 2017 and 2024;
• Aged 18 years or older at baseline;
• Completed an abdominal ultrasound examination during the health check-up.

You may not qualify if:

• Underweight status at baseline, defined as BMI \< 18.5 kg/m² ；
• Missing data on height, weight, or components of the metabolic syndrome ;
• Baseline diagnosis of MASLD or any other liver diseases
• Baseline diagnosis of hyperuricemia

Sponsors & Collaborators

• Ningbo No. 1 Hospital: lead

Study Sites (1)

the First Affiliated Hospital of Ningbo University Ningbo, Zhejiang, China, 315000, Ningbo, Zhejiang Province 315000 Recruiting

Ningbo, China

Location

MeSH Terms

Conditions

Obesity, Metabolically Benign; Hyperuricemia

Condition Hierarchy (Ancestors)

Obesity; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Pathologic Processes

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 25, 2025
• First Posted: June 3, 2025
• Study Start: April 1, 2025
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: June 3, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)