Videonystagmography and Vestibular Migraine

NCT07000929 | Completed

• 1 other identifier: VM_LB_DHL
• Study Type: observational
• Target: 173
• Locations: 1 country
• Sites: 1

Brief Summary

In the study, the investigators would like to examine whether there is a difference between patients with vestibular migraine, patients with episodic or chronic migraine and healthy subjects in the examination of videonystagmography, which has been used for many years to differentiate and diagnose vertigo disorders. Accordingly, videonystagmography could also be discussed as an important diagnostic instrument for the diagnosis of the still young disease vestibular migraine.

Conditions

Migraine Disorders; Vertigo

Keywords

Vestibular migraine; Vertigo; Migraine; Dizziness

Outcome Measures

Primary Outcomes (3)

• mean comparison nystagmus frequency

  Comparison of the mean between the group of patients with vestibular migraine and the patients and healthy participants in the mean nystagmus frequency within 30 seconds

  Mean of nystagmus frequency at study enrollment, Baseline

• mean comparison GLP (speed of the slow phase) of nystagmus in °/s or sum of °/s

  Comparison of the mean between the group of patients with vestibular migraine and the patients and healthy participants in the mean GLP of nystagmus in °/s or sum of °/s

  Mean of nystagmus GLP at study enrollment, Baseline

• Comparison head impulse test (vHIT)

  Comparison of the mean between the group of patients with vestibular migraine and the patients and healthy participants in the qualitativ analysis of the head impulse test

  result of head impulse test at study enrollment, Baseline

Study Arms (3)

Vestibular migraine confirmed

Patients who received a diagnosis of vestibular migraine.

Diagnostic Test: Videonystagmography

Episodic or chronic migraine, without vestibular migraine

Patients who received a diagnosis of episodic or chronic migraine without vestibular migraine.

Diagnostic Test: Videonystagmography

Healthy participants

Patients who not received a diagnosis of episodic or chronic migraine nor vestibular migraine.

Diagnostic Test: Videonystagmography

Interventions

Videonystagmography DIAGNOSTIC_TEST

In the regular examination of patients with vertigo, videonystagmography with thermal testing (caloric) is already an established and necessary examination procedure that is used to diagnose many different vertigo disorders.

Episodic or chronic migraine, without vestibular migraine; Healthy participants; Vestibular migraine confirmed

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The sample of patients was recruited from the dizziness center of the University Hospital Essen. The patients with migraine were recruited partly from the headache center and partly via advertising. The healthy subjects were recruited through advertising.

You may qualify if:

• Group 1: The diagnosis of vestibular migraine is confirmed.
• Group 2: The diagnosis of episodic or chronic migraine is confirmed. There is no coexisting vestibular migraine.
• Group 3: healthy subjects without vestibular migraine and episodic or chronic migraine

You may not qualify if:

• Simultaneous presence of another confirmed vertigo disorder
• A previous hearing loss
• Simultaneous presence of a chronic disease that affects the sense of balance
• Taking medication with a central effect that affects the sense of balance
• An existing eardrum defect or a blocked ear canal due to earwax

Sponsors & Collaborators

• Dr. med. Lukas Becker: lead
• University Hospital, Essen: collaborator

Study Sites (1)

Westdeutsches Kopfschmerz und Schwindelzentrum der Klinik für Neurologie des Universitätklinikums Essen

Essen, North Rhine-Westphalia, 45147, Germany

Location

Related Publications (3)

• Rocha MF, Sacks B, Al-Lamki A, Koohi N, Kaski D. Acute vestibular migraine: a ghost diagnosis in patients with acute vertigo. J Neurol. 2023 Dec;270(12):6155-6158. doi: 10.1007/s00415-023-11930-9. Epub 2023 Aug 19. No abstract available.

  PMID: 37597072 BACKGROUND

• Muelleman T, Shew M, Subbarayan R, Shum A, Sykes K, Staecker H, Lin J. Epidemiology of Dizzy Patient Population in a Neurotology Clinic and Predictors of Peripheral Etiology. Otol Neurotol. 2017 Jul;38(6):870-875. doi: 10.1097/MAO.0000000000001429.

  PMID: 28498271 BACKGROUND

• Lempert T, Olesen J, Furman J, Waterston J, Seemungal B, Carey J, Bisdorff A, Versino M, Evers S, Newman-Toker D. Vestibular migraine: diagnostic criteria. J Vestib Res. 2012;22(4):167-72. doi: 10.3233/VES-2012-0453.

  PMID: 23142830 BACKGROUND

MeSH Terms

Conditions

Migraine Disorders; Vertigo; Dizziness

Condition Hierarchy (Ancestors)

Headache Disorders, Primary; Headache Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vestibular Diseases; Labyrinth Diseases; Ear Diseases; Otorhinolaryngologic Diseases; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Sensation Disorders

Study Officials

• Dagny Holle-Lee, Prof. Dr. med.

  Klinik für Neurologie, Universitätsklinikum Essen

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: May 14, 2025
• First Posted: June 3, 2025
• Study Start: October 16, 2023
• Primary Completion: December 31, 2025
• Study Completion: December 31, 2025
• Last Updated: February 27, 2026

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share

Locations

DE (1)