Ovarian Reserve in Intensive Care Patients

NCT06999291 | Not Yet Recruiting

• 1 other identifier: OR-2024
• Study Type: observational
• Target: 75
• Locations: 0 countries
• Sites: N/A

Brief Summary

Gastrointestinal, pulmonary, nephrological, cardiac, neurologic and psychological effects in critically ill patients followed in the intensive care unit have been shown in the literature. However, the effects on ovarian reserve in these patients have not been sufficiently investigated and studies investigating this issue are limited in the literature. The synthesis, release frequency and amplitude of reproductive hormones change under stress. In addition, changes in ovarian homeostasis affect ovarian reserve. The aim of this study was to evaluate ovarian reserve in critically ill patients followed up in the intensive care unit.

Conditions

Anti-Mullerian Hormone Deficiency

Outcome Measures

Primary Outcomes (1)

• ovarian follicle count

  Ovarian reserve will be checked with ultrasound

  24 hour

Study Arms (3)

internal intensive care

Patients hospitalized in intensive care for internal reasons

Behavioral: Glaskow coma scala, The Acute Physiology and Chronic Health Evaluation System- APACHE, Injury Severity Score- ISS)

surgical intensive care

Patients hospitalized in intensive care for surgical reasons

Behavioral: Glaskow coma scala, The Acute Physiology and Chronic Health Evaluation System- APACHE, Injury Severity Score- ISS)

Outpatient clinic patients

Healthy female patients admitted to gynecology outpatient clinic

Behavioral: Glaskow coma scala, The Acute Physiology and Chronic Health Evaluation System- APACHE, Injury Severity Score- ISS)

Interventions

Glaskow coma scala, The Acute Physiology and Chronic Health Evaluation System- APACHE, Injury Severity Score- ISS) BEHAVIORAL

The uterus, endometrium and ovarian characteristics, endometrial thickness, ovarian follicle number and ovarian volume parameters, hormone panel (FSH, LH, E2, AMH), cortisol, prolactin and thyroid function tests routinely examined for ovarian reserve will be evaluated in the study.

Outpatient clinic patients; internal intensive care; surgical intensive care

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

a group of healthy women without any disease and a group of patients hospitalized in intensive care unit.

You may qualify if:

• years of age
• Female patients followed in the intensive care unit for more than 24 hours for internal or surgical reasons,
• Women whose ovarian reserve is being evaluated,

You may not qualify if:

• Previous ovarian surgery, endometriosis, endometrioma,
• History of chemotherapy, radiotherapy,
• Ovarian cyst, malignancy and other ovarian pathologies,
• Women with single ovary,
• Women receiving hormone therapy,
• Polycystic ovary syndrome,
• Surgical intervention within the last 6 months,
• History of drug, alcohol, substance use,
• Women in pregnancy, puerperium, lactation,
• History of vaccination within the last 6 months

Sponsors & Collaborators

• Haseki Training and Research Hospital: lead

Related Publications (2)

• Kayambankadzanja RK, Schell CO, Gerdin Warnberg M, Tamras T, Mollazadegan H, Holmberg M, Alvesson HM, Baker T. Towards definitions of critical illness and critical care using concept analysis. BMJ Open. 2022 Sep 5;12(9):e060972. doi: 10.1136/bmjopen-2022-060972.

  PMID: 36606666 RESULT

• Moolhuijsen LME, Visser JA. Anti-Mullerian Hormone and Ovarian Reserve: Update on Assessing Ovarian Function. J Clin Endocrinol Metab. 2020 Nov 1;105(11):3361-73. doi: 10.1210/clinem/dgaa513.

  PMID: 32770239 RESULT

MeSH Terms

Interventions

Injury Severity Score

Intervention Hierarchy (Ancestors)

Trauma Severity Indices; Medical Records; Records; Data Collection; Epidemiologic Methods; Investigative Techniques; Organization and Administration; Health Services Administration; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation

Central Study Contacts

emine yılmaz güler

CONTACT

905054525261; dr.emine.yilmaz@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: May 7, 2025
• First Posted: May 31, 2025
• Study Start: June 15, 2025
• Primary Completion: July 15, 2025
• Study Completion: November 15, 2025
• Last Updated: May 31, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share