Phase I Study on the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of a Single Subcutaneous Injection of SHR-2173 in Healthy Subjects

NCT06995001 | Completed Phase 1

• 1 other identifier: SHR-2173-101
• Study Type: interventional
• Target: 35
• Locations: 1 country
• Sites: 1

Brief Summary

The study is being conducted to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics and immunogenicity of a single dose of SHR-2173 by subcutaneous injection.

Conditions

Healthy Volunteers

Outcome Measures

Primary Outcomes (1)

• Treatment-emergent Adverse Events (TEAE)

  Day1~Day71

Secondary Outcomes (8)

• Cmax

  Day1~Day71

• AUC0-t

  Day1~Day71

• AUC0-∞

  Day1~Day71

• Tmax,

  Day1~Day71

• t1/2,

  Day1~Day71

Study Arms (5)

Treatment group A

EXPERIMENTAL

Drug: SHR-2173

Treatment group B

EXPERIMENTAL

Drug: SHR-2173 ；Placebo

Treatment group C

EXPERIMENTAL

Drug: SHR-2173 ；Placebo

Treatment group D

EXPERIMENTAL

Drug: SHR-2173 ；Placebo

Treatment group E

EXPERIMENTAL

Drug: SHR-2173 ；Placebo

Interventions

SHR-2173 DRUG

SHR-2173 injection dose 1；

Treatment group A

SHR-2173 ；Placebo DRUG

SHR-2173 injection dose 2 ；Pacebo dose 2

Treatment group B

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy male or female between the ages of 18 and 45 years, inclusive;
• At least 50.0 kg for male subjects, 45.0 kg for female subjects, with a Body Mass Index (BMI) between 19.0-28.0 kg/m2 , inclusive (BMI = weight/height2 );
• Female subjects of childbearing potential or male subjects whose partners are women of childbearing must avoid sperm/ovum donation and adopt highly effective contraceptive measurements (non-pharmacological contraception is required during the trial period) from the time of signing the informed consent form until the final visit;
• Subjects who could understand the details, procedures, and possible adverse reactions of the trial before it begins and voluntarily sign a written informed consent form。

You may not qualify if:

• Subjects with a history of drug allergies, or those with an allergic constitution (e.g., allergic to two or more drugs, foods, or pollens), or those known to be allergic to the investigational drug (including excipients) or similar drugs;
• History or presence of any condition that may affect the safety or the pharmacokinetics of the investigational drug, including: immune system, respiratory system, hematological system (e.g., hemolytic reactions), circulatory system, digestive system, urinary system, nervous system, endocrine system, psychiatric disorders, metabolic disorders, or other conditions deemed unsuitable for participation in clinical trials;
• Presence of active infection;
• History of severe herpes virus infection, or history or presence of malignant tumors;
• History of risk factors for torsades de pointes ventricular tachycardia, such as unexplained syncope, confirmed long QT syndrome (including family history), heart failure, myocardial infarction, or angina pectoris;
• Subjects who have undergone major surgery within 3 months prior to screening, or surgery that may significantly affect the pharmacokinetics or safety evaluation of the investigational drug, or those planning to undergo surgery during the trial period.
• Subjects who have used or are currently using any prescription drugs, over-the-counter medications, functional vitamins, health supplements, or herbal products within 2 weeks prior to dosing; or those planning to use other drugs during the trial period;
• Subjects who have been vaccinated within 30 days prior to dosing or plan to be vaccinated within 3 months after dosing.
• Subjects with a 12-lead ECG showing first-degree or higher atrioventricular block, atrial fibrillation or flutter, QTcF ≥450 ms, or other clinically significant abnormalities as judged by the investigator during the screening period;
• Subjects with clinically significant abnormalities in blood routine, urinalysis, blood biochemistry, coagulation function, physical examination, vital signs, chest X-ray, or abdominal ultrasound as judged by the investigator during the screening period;
• Subjects with positive results for hepatitis B surface antigen, hepatitis C virus antibody, Treponema pallidum antibody, or human immunodeficiency virus (HIV) during the screening period;
• Pregnant or lactating females, or subjects with a positive serum pregnancy test;
• Subjects with a positive tuberculosis infection screening test (interferon-gamma release assay, IGRA); IGRA includes but is not limited to QuantiFERON-TB Gold In-Tube (QFT-GIT) and T-SPOT.TB. If the IGRA result is indeterminate, retesting is allowed. Subjects with two indeterminate results will be considered positive.
• Subjects who participated in other clinical trials and used investigational drugs within 3 months prior to dosing, or whose last study ended less than 5 half-lives or the duration of biological effects (whichever is longer);
• Subjects who donated blood or lost ≥200 mL of blood (excluding menstrual blood loss in females) within 3 months prior to dosing, or received blood transfusions or blood products, or donated platelets within 2 weeks prior to dosing, or plan to donate blood during or within 3 months after the trial;

Sponsors & Collaborators

• Guangdong Hengrui Pharmaceutical Co., Ltd: lead

Study Sites (1)

Haikou People's Hospital

Haikou, Hainan, 570208, China

Location

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 15, 2025
• First Posted: May 29, 2025
• Study Start: April 28, 2024
• Primary Completion: November 28, 2024
• Study Completion: November 28, 2024
• Last Updated: May 29, 2025

Record last verified: 2025-05

Locations

CN (1)