Impact of Minimally Invasive Non-surgical Periodontal Treatment on Infrabony Defects

NCT06992219 | Completed

• 1 other identifier: 2024-3308
• Study Type: interventional
• Target: 52
• Locations: 1 country
• Sites: 1

Brief Summary

Fifty-two periodontitis patients (26 per group) were randomly assigned to the test (Minimally invasive non-surgical therapy - MINST) or the control group (Quadrantwise Subgingival Instrumentation - Q-SI) NPT protocols.

Conditions

Periodontal Intrabony Defect

Keywords

periodontitis

Outcome Measures

Primary Outcomes (1)

• Probing Pocket Depth Reduction

  Probing Pocket Depth Reduction in Probing Pocket Depth after treatment

  1-year

Study Arms (2)

MINST non surgical periodontal treatment

EXPERIMENTAL

MINST non surgical periodontal treatment Periodontitis patients treated by means of MINST for infrabony defects. Patients were treated with non-surgical MINST periodontal treatment in a single session.

Other: Non surgical periodontal treatment evaluated through probing pocket depth reduction

Q-SI non surgical periodontal treatment

ACTIVE COMPARATOR

Periodontitis patients treated by means of Q-SI. Patients were treated with non-surgical quadrantwise periodontal treatment in 4 sessions, 1 session per week.

Other: Non surgical periodontal treatment evaluated through probing pocket depth reduction

Interventions

Non surgical periodontal treatment evaluated through probing pocket depth reduction OTHER

Patients were treated with Minimally invasive non surgical treatment (MINST) or quadrant-subgingival instrumentation (Q-SI). The efficacy of treatment in both groups was evaluated through Probin Pocket Depth reduction in millimetres measurement before and after treatment.

MINST non surgical periodontal treatment; Q-SI non surgical periodontal treatment

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Diagnosis of Periodontitis

You may not qualify if:

• Periodontal treatment
• Use of antibiotics, NSAIDs, and immunosuppressants during the last 6 months
• Pregnancy

Sponsors & Collaborators

• University of Catania: lead

Study Sites (1)

AOU Policlinico G. Rodolico

Catania, 95124, Italy

Location

MeSH Terms

Conditions

Periodontitis

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Study Officials

• Gaetano Isola, DDS

  Università degli Studi di Catania

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: Sealed envelopes
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Model Details: Non-surgical periodontal treatment Subgingival biofilm ultrasonic debridement with MINST or Q-SI for infrabony defects

Study Record Dates

• First Submitted: May 18, 2025
• First Posted: May 28, 2025
• Study Start: October 1, 2022
• Primary Completion: November 30, 2024
• Study Completion: November 30, 2024
• Last Updated: May 28, 2025

Record last verified: 2025-05

Locations

IT (1)