What Lies Beneath the Stone? Metabolic Insights From Composition-Based Analysis of Kidney Stones

NCT06992206 | Completed DMC

• 1 other identifier: Hisar-KSD-2025-33
• Study Type: observational
• Target: 506
• Locations: 0 countries
• Sites: N/A

Brief Summary

This retrospective observational study investigates the metabolic abnormalities associated with different types of kidney stones by analyzing their composition. The study includes adult patients diagnosed with urolithiasis, whose stone samples were analyzed using Fourier Transform Infrared (FTIR) spectroscopy. Clinical, biochemical, and 24-hour urine metabolic parameters were compared between first-time and recurrent stone formers, and among subtypes of calcium oxalate stones (monohydrate vs. dihydrate). The goal is to identify metabolic risk factors that contribute to stone formation and recurrence, and to provide insights for individualized prevention strategies.

Conditions

Urolithiasis, Calcium Oxalate

Keywords

Calcium oxalate; Metabolic evaluation; Urolithiasis; Stone composition

Outcome Measures

Primary Outcomes (1)

• Kalsiyum oksalat taşı tipine göre serum ve 24 saatlik idrar parametrelerinin dağılımı Zaman Çerçevesi (Time Frame): 01 Ocak 2010 - 31 Aralık 2024 tarihleri arasında toplanan hasta verileri

  FTIR spektroskopisi ile taş bileşimi belirlenen hastalar arasında, kalsiyum oksalat monohidrat (COM) ve dihidrat (COD) taşı olan bireylerin metabolik parametreleri (serum kalsiyum, fosfor, magnezyum, parathormon; 24 saatlik idrarla kalsiyum, oksalat, sitrat, pH, Na, ürik asit vb.) retrospektif olarak analiz edilmiştir.

  January 2010 and December 2024

Study Arms (2)

First-time Stone Formers

Adult patients who presented with their first episode of kidney stone disease. These patients underwent stone composition analysis via FTIR spectroscopy and metabolic evaluation including serum and 24-hour urine testing to identify risk factors for initial stone formation.

Other: Metabolik taş analizi ile retrospektif gözlem

Recurrent Stone Formers

Patients with a documented history of recurrent kidney stone episodes. These individuals were evaluated to assess differences in metabolic profiles and stone composition compared to first-time stone formers, with the aim of identifying predictors of recurrence and optimizing preventive strategies.

Other: Metabolik taş analizi ile retrospektif gözlem

Interventions

Metabolik taş analizi ile retrospektif gözlem OTHER

This study did not involve an active intervention. It retrospectively analyzed medical records of 506 patients who underwent compositional analysis of kidney stones to identify metabolic abnormalities. The aim was to evaluate stone composition in relation to metabolic parameters such as serum and 24-hour urine values, without modifying patient treatment.

Also known as: Böbrek taşı kompozisyonu değerlendirmesi Retrospektif metabolik değerlendirme

First-time Stone Formers; Recurrent Stone Formers

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study included 506 patients who presented with nephrolithiasis and underwent metabolic evaluation of stone composition. Data were collected retrospectively from medical records at Hisar Intercontinental Hospital between 2010 and 2024.

You may qualify if:

• Age ≥ 18 years
• Patients diagnosed with kidney stones between January 2010 and December 2024
• Stone composition analyzed via Fourier-transform infrared (FTIR) spectroscopy
• Available metabolic panel including serum and 24-hour urine values

You may not qualify if:

• Patients with secondary hyperparathyroidism, renal tubular acidosis, or other systemic metabolic diseases affecting stone formation
• Patients with incomplete medical records
• Patients with non-calcium-based stones (e.g., uric acid, struvite, cystine)

Sponsors & Collaborators

• Hisar Intercontinental Hospital: lead

MeSH Terms

Conditions

Nephrolithiasis, Calcium Oxalate; Urolithiasis

Condition Hierarchy (Ancestors)

Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Prof.Dr

Study Record Dates

• First Submitted: May 18, 2025
• First Posted: May 28, 2025
• Study Start: January 1, 2010
• Primary Completion: December 31, 2024
• Study Completion: December 31, 2024
• Last Updated: May 28, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ANALYTIC CODE
• Time Frame: Data will be made available 6 months after publication of the main study results and will remain accessible for a period of 36 months upon request.
• Access Criteria: Qualified researchers affiliated with academic or healthcare institutions may request access to the de-identified IPD for secondary analysis or meta-analysis. Requests should be submitted to the corresponding author with a detailed research proposal. Data access will be granted following review and under a data-sharing agreement.