Comparison of Needling and Microneedling Plus Phototherapy in Localized Vitiligo Patients
Puncture to Repigment: A Comparative Analysis Of Needling vs. Microneedling Along With NBUVB in Treatment of Non-Segmental Vitiligo
1 other identifier
interventional
80
1 country
1
Brief Summary
This randomized controlled trial aims to compare the efficacy of needling versus microneedling, both followed by narrowband UVB therapy, in achieving repigmentation in patients with localized stable non-segmental vitiligo.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for phase_4
Started Mar 2025
Shorter than P25 for phase_4
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2025
CompletedFirst Submitted
Initial submission to the registry
May 19, 2025
CompletedFirst Posted
Study publicly available on registry
May 28, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 31, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
August 31, 2025
CompletedSeptember 2, 2025
August 1, 2025
6 months
May 19, 2025
August 25, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Treatment efficacy
Efficacy will be assessed at 12 weeks using the Physician's Global Assessment Scale. Improvement is defined as ≥25% repigmentation of vitiliginous patches, measured via digital planimetry and standardized clinical photography. The higher the score, the more effective is the treatment modality. 0-25% re pigmentation= Mildimprovement 25-50% re pigmentation= Moderate improvement 51-75% re pigmentation= Good 76-100% re pigmentation= Excellent to complete
12 weeks
Secondary Outcomes (1)
Adverse effects
12 weeks
Study Arms (2)
Needling + NBUVB(Group A)
ACTIVE COMPARATORMicroneedling + NBUVB(Group B)
ACTIVE COMPARATORInterventions
Participants in this arm will undergo needling using a sterile 30G (4mm) needle to manually puncture and implant melanocytes from perilesional pigmented skin into depigmented lesions. The procedure will be performed once every four weeks for a total of six sessions.
Participants in this arm will undergo microneedling using a Dermapen device with 1.5 mm needles to create controlled micro-injuries in depigmented skin to enhance melanocyte migration and repigmentation. This procedure will be performed once every four weeks for six sessions.
Eligibility Criteria
You may qualify if:
- Both male and female
- Age 15-60 years
- Patients having vitiligo for more than 1 year
You may not qualify if:
- Patients with tendency of keloid formation or hypertrophic scarring
- Patients with any bleeding disorder, coagulation defect or using anti platelets
- Any local infection at the treatment site
- Patients who had received systemic therapy in last 6 months
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Khyber Teaching Hospital
Peshawar, Khyber Pakhtunkhwa, 25000, Pakistan
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Huma Gul Doctor, MBBS
Khyber Teaching Hospital
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- phase 4
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- DOCTOR
Study Record Dates
First Submitted
May 19, 2025
First Posted
May 28, 2025
Study Start
March 1, 2025
Primary Completion
August 31, 2025
Study Completion
August 31, 2025
Last Updated
September 2, 2025
Record last verified: 2025-08
Data Sharing
- IPD Sharing
- Will not share
Patient's confidentiality may not be breached