Cognitive Remediation for Autistic Adolescents
A Pilot Study of Cognitive Remediation Therapy for Autistic Adolescents
1 other identifier
interventional
20
1 country
1
Brief Summary
Autistic youth have extremely high levels of co-occurring mental health difficulties, including rates of depression and anxiety which are between two and four times more common compered to non-autistic people. Cognitive inflexibility is a characteristic which is strongly associated with higher levels of anxiety and depression in autism. Currently, there are no existing treatments which can promote flexible thinking. Cognitive Remediation Therapy is a promising intervention which has been used with different patient groups to improve flexibility. This study aims to develop and adapt the current CRT treatment for use with autistic youth and then conduct a pilot study with 20 participants.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for early_phase_1
Started May 2024
Shorter than P25 for early_phase_1
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 8, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2025
CompletedFirst Submitted
Initial submission to the registry
May 7, 2025
CompletedFirst Posted
Study publicly available on registry
May 25, 2025
CompletedMay 25, 2025
May 1, 2025
12 months
May 7, 2025
May 21, 2025
Conditions
Outcome Measures
Primary Outcomes (4)
Acceptability 1 - Drop out rate
Number of participants who drop-out from the study
8 weeks
Acceptability 2 - session attendance rate:
total number of sessions attended out of a maximum of 8 per participant
8 weeks
Acceptability 3 - adherence to the therapy protocol
Completion rates of between session work - recorded as percentage.
8 weeks
Acceptability 4 - Semi-structured qualitative interviews post intervention
8 weeks
Secondary Outcomes (5)
Cognitive Flexibility Scale
8 weeks
DFLEX
8 weeks
Revised Child Anxiety and Depression Scale
8 weeks
Mood and Feelings Questionnaire
8 weeks
Work and Social Adjustment Scale
8 weeks
Study Arms (1)
Intervention
EXPERIMENTALSingle arm for pilot study
Interventions
Eligibility Criteria
You may qualify if:
- years of age with a confirmed clinical diagnosis of autism (based on verified diagnostic report).
- Verbal/intellectual ability in average range
- Sufficient spoken English to access the intervention.
- Young person must be under the care of a local mental health service who can respond to any changes in routine clinical care / risk issues that arise.
You may not qualify if:
- Not currently receiving alternative psychological intervention
- Not actively self-harming or deemed at risk to themselves or others
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
King's College London
London, London, SE5, United Kingdom
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- early phase 1
- Allocation
- NA
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 7, 2025
First Posted
May 25, 2025
Study Start
May 8, 2024
Primary Completion
May 1, 2025
Study Completion
May 1, 2025
Last Updated
May 25, 2025
Record last verified: 2025-05
Data Sharing
- IPD Sharing
- Will not share