Comparison of the Effects of Sugammadex and Neostigmine on Early Extubation, Intensive Care Unit Admission and Length of Stay, and Hospital Costs in Adult Cranial Surgery

NCT06987357 | Completed

• 1 other identifier: KAEK/2021.04.116
• Study Type: observational
• Target: 112
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study was to retrospectively investigate the effects of sugammadex or neostigmine, which are routinely used after the completion of surgery to antagonize (reverse) neuromuscular blockade in adult patients undergoing cranial surgery under general anesthesia, on early extubation in the operating room, intensive care unit admission and length of stay, length of hospital stay, and hospital costs.

Conditions

Craniectomy; Sugammadex; Extubation; Recovery After Neuromuscular Block; Hospital Costs

Outcome Measures

Primary Outcomes (3)

• The amount of cost in the hospital process

  through study completion, an average of 3 month

• Length of stay in the intensive care unit

  through study completion, an average of 3 month

• Early extubation rate after two different neuromuscular blocking antagonist drugs

  through study completion, an average of 3 month

Study Arms (2)

Group Neostigmine

Group Sugammadex

Eligibility Criteria

• Age: 19 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Among the patients who underwent cranial surgery under sevoflurane anesthesia and whose neuromuscular blockade was provided with rocuronium, the patients whose neuromuscular blockade was antagonized with neostigmine or sugammadex and who were admitted to the intensive care unit postoperatively were evaluated.

You may qualify if:

• Patients from the American Society of Anesthesiology (ASA) I-II-III group,
• over the age of 18,
• who underwent elective surgery,
• underwent general anesthesia with sevoflurane anesthesia from volatile anesthetics,
• used rocuronium as a neuromuscular blocking agent

You may not qualify if:

• Patients aged 18 and under,
• ASA IV and above,
• who underwent surgery under emergency conditions,
• who have incomplete follow-up form records and electronic media data,
• who were taken to the intensive care unit without neuromuscular blockade antagonism due to long surgery,
• who were treated with a neuromuscular blocking agent other than rocuronium,
• who were treated with a volatile anesthetic other than sevoflurane or with total intravenous anesthesia.

Sponsors & Collaborators

• Kanuni Sultan Suleyman Training and Research Hospital: lead

Study Sites (1)

Kanuni Sultan Suleyman Training and Research Hospital

Istanbul, Turkey (Türkiye)

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Specialist

Study Record Dates

• First Submitted: May 9, 2025
• First Posted: May 23, 2025
• Study Start: May 1, 2021
• Primary Completion: July 31, 2021
• Study Completion: July 31, 2021
• Last Updated: May 23, 2025

Record last verified: 2025-05

Locations

TU (1)